2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14179
    Cytovaricin
    		Inhibitor
    Cytovaricin has the activity of inhibiting Yoshida sarcoma cells and has weak anti-phytopathogenic fungi and chlorella activity.
    Cytovaricin
  • HY-126484
    Eremofortin B
    		Inhibitor
    Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT).
    Eremofortin B
  • HY-N14524
    Gladiolic acid
    		Inhibitor
    Gladiolic acid has the antifungal activity of Absidia glauca Hagem, garlic spores, Byssochlamys fulva, Trichophyton mentagrophytes, Corpuscular falciparum.
    Gladiolic acid
  • HY-N14211
    Polyoxin F
    		Inhibitor
    Polyoxin F is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin F
  • HY-166670S
    Ketoconazole carbonyl-13C
    		Inhibitor
    Ketoconazole carbonyl-13C (Ketoconazol-13C) is 13C labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole carbonyl-<sup>13</sup>C
  • HY-135422
    Nidulin
    		Inhibitor
    Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp.
    Nidulin
  • HY-N14353
    Papulacandins A
    Papulacandins A is an antibiotic. Papulacandins A can be found in the fungus Papularia sphaerosperma. Papulacandins A has strong anti-yeast effect, but has no effect on filamentous fungi, bacteria and protozoa.
    Papulacandins A
  • HY-N15024
    Eupenoxide
    		Inhibitor
    Eupenoxide is an antibiotic with antifungal activity that can be found by fungi of the genus Eupenicillium.
    Eupenoxide
  • HY-N0672R
    Pseudolaric Acid C (Standard)
    		Inhibitor
    Pseudolaric Acid C (Standard) is the analytical standard of Pseudolaric Acid C. This product is intended for research and analytical applications. Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity.
    Pseudolaric Acid C (Standard)
  • HY-N10318
    Erigeside II
    		Inhibitor
    Erigeside II is a sesquiterpene glycoside found in the root bark of Dictamnus dasycarpus. Erigeside II stimulates the proliferation of T-cells.
    Erigeside II
  • HY-101424
    2-Chloro-N-(2-methyl-4-bromophenyl)acetamide
    		Inhibitor
    2-Chloro-N-(2-methyl-4-bromophenyl)acetamide is an antifungal compound.
    2-Chloro-N-(2-methyl-4-bromophenyl)acetamide
  • HY-125487
    Appenolide A
    		Inhibitor
    Appenolide A is an antifungal furanones that can be isolated from the coprophilous fungus Podospora appendiculata.
    Appenolide A
  • HY-127000
    Julifloricine
    		Inhibitor
    Julifloricine is an alkaloid from Prosopis juliflora. Julifloricine has antibacterial activity.
    Julifloricine
  • HY-N14912
    β-Prumycin hydrochloride
    		Inhibitor
    β-Prumycin hydrochloride is a carbohydrate antibiotic. β-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.
    β-Prumycin hydrochloride
  • HY-B0847R
    Propiconazole (Standard)
    		Inhibitor
    Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals.
    Propiconazole (Standard)
  • HY-N4102R
    5,7-Dihydroxy-4-methylcoumarin (Standard)
    		Inhibitor
    5,7-Dihydroxy-4-methylcoumarin (Standard) is the analytical standard of 5,7-Dihydroxy-4-methylcoumarin. This product is intended for research and analytical applications. 5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities.
    5,7-Dihydroxy-4-methylcoumarin (Standard)
  • HY-N13875
    Antiblastin
    		Inhibitor
    Antiblastin is an antifungal antibiotic found in Gloeosporium olivarum cultures.
    Antiblastin
  • HY-136752
    CYP51-IN-2
    		Inhibitor
    CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-2
  • HY-126770
    Rhizocticin A
    		Inhibitor
    Rhizocticin A is an antifungal phosphono-oligopeptide against Ascodesmis, Plicaria, Rhizoctonia with MIC of 3.5 μg/mL. Rhizocticin A produces toxic L-2-Amino-5-phospho-3-cis-pentenoic acid (L-APPA), which may interfere with cell metabolism.
    Rhizocticin A
  • HY-125569
    Leucomycin A5
    		Inhibitor
    Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively.
    Leucomycin A5
Cat. No. Product Name / Synonyms Application Reactivity