2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15042
    9-Hydroxyoudemansin A
    		Inhibitor
    9-Hydroxyoudemansin A is an antibiotic. 9-Hydroxyoudemansin A has antifungal activity, has an MIC of 12.5 μg/mL against ochre-like yeast, and is resistant to fungi such as Candida albicans, Crimson Yeast, Penicillium and Streptomyces with MICs are all> 50 μg/mL. No anti-bacterial effect.
    9-Hydroxyoudemansin A
  • HY-W020043R
    Pyribencarb (Standard)
    		Inhibitor
    Pyribencarb (Standard) is the analytical standard of Pyribencarb. This product is intended for research and analytical applications. Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against Botrytis cinerea and Sclerotinia sclerotirum.
    Pyribencarb (Standard)
  • HY-N14282
    Ezomycin B2
    		Inhibitor
    Ezomycin B2 is an antibiotic with antifungal activity.
    Ezomycin B2
  • HY-100069R
    Fluazinam impurity 1 (Standard)
    		Inhibitor
    Fluazinam impurity 1 (Standard) is the analytical standard of Fluazinam impurity 1. This product is intended for research and analytical applications. Fluazinam impurity 1 is an impurity of Fluazinam with antifungal activity. Fluazinam impurity 1 is active against Sphaerotheca fuliginea, Pyricularia oryzae and Rhizoctonia solani.
    Fluazinam impurity 1 (Standard)
  • HY-B1858R
    Isoprothiolane (Standard)
    		Inhibitor
    Isoprothiolane (Standard) is the analytical standard of Isoprothiolane (HY-B1858). This product is intended for research and analytical applications. Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver.
    Isoprothiolane (Standard)
  • HY-120734R
    Quinoxyfen (Standard)
    		Inhibitor
    Quinoxyfen (Standard) is the analytical standard of Quinoxyfen. This product is intended for research and analytical applications. Quinoxyfen (DE-795) is a powdery mildew fungicide.
    Quinoxyfen (Standard)
  • HY-N14023
    Glidobactin G
    		Inhibitor
    Glidobactin G is an anti-tumor antibiotic. Glidobactin G has the activity against pathogenic fungi and yeast. Glidobactin G also extends the survival of mice inoculated with leukemia P388 cells.
    Glidobactin G
  • HY-105477
    Maniwamycin A
    		Inhibitor
    Maniwamycin A ((-)-Maniwamycin A) has anti-fungal effect.
    Maniwamycin A
  • HY-B0518AS
    Naftifine-d3 hydrochloride
    		Inhibitor
    Naftifine-d3 (hydrochloride) is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.
    Naftifine-d<sub>3</sub> hydrochloride
  • HY-17395S1
    Terbinafine-d5 hydrochloride
    		Inhibitor
    Terbinafine-d5 (TDT 067-d5) hydrochloride is deuterium-labeled Terbinafine hydrochloride (HY-17395).
    Terbinafine-d<sub>5</sub> hydrochloride
  • HY-N14213
    Polyoxin H
    		Inhibitor
    Polyoxin H is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin H
  • HY-169919
    HDM-IN-1
    		Inhibitor
    HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model.
    HDM-IN-1
  • HY-N15453
    Asperenone
    		Inhibitor
    Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC50 value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC50 value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields.
    Asperenone
  • HY-129432
    (-)-Deacetylsclerotiorin
    		Control
    (-)-Deacetylsclerotiorin (Compound 30) is the enantiomer of Deacetylsclerotiorin (HY-126167). Deacetylsclerotiorin is the metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7.45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM).
    (-)-Deacetylsclerotiorin
  • HY-126724
    Flutianil
    		Inhibitor
    Flutianil is a fungicide, which specifically inhibits the powdery mildew species. Flutianil inhibits the haustorium formation and subsequent mycelia growth.
    Flutianil
  • HY-N12808
    (E)-4-Methyl-5-styrylbenzene-1,3-diol
    		Inhibitor
    (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent and can be extracted from Dracaena cochinchinensis (Lour.) S. C. Chen.
    (E)-4-Methyl-5-styrylbenzene-1,3-diol
  • HY-146024
    Antifungal agent 28
    		Inhibitor
    Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm.
    Antifungal agent 28
  • HY-119067
    Aspirochlorine
    		Inhibitor
    Aspirochlorine (A30641) is an antibiotc with activity against Gram-positive bacteria and fungi.
    Aspirochlorine
  • HY-N6687R
    Calcimycin (Standard)
    		Inhibitor
    N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively.
    Calcimycin (Standard)
  • HY-157459
    SDH-IN-11
    		Inhibitor
    SDH-IN-11 (compound A7) is a SDH inhibitor, and shows inhibitory effect on nematode feeding, reproductive ability, and egg hatching. SDH-IN-11 promotes the oxidative stress of nematodes and causes intestinal damage to nematodes. SDH-IN-11 inhibits the activity of succinate dehydrogenase (SDH) in nematodes.
    SDH-IN-11
Cat. No. Product Name / Synonyms Application Reactivity