2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14434
    Pradimicin B
    		Inhibitor
    Pradimicin B is an antibiotic. Pradimicin B has strong antifungal and yeast activity.
    Pradimicin B
  • HY-12396R
    Aminothiazole (Standard)
    		Inhibitor
    Aminothiazole (Standard) is the analytical standard of Aminothiazole. This product is intended for research and analytical applications. Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators.
    Aminothiazole (Standard)
  • HY-N14991
    Acrylamidine
    		Inhibitor
    Acrylamidine has weak anti-mold and yeast activity.
    Acrylamidine
  • HY-B0850S
    Difenoconazole-d6 hydrochloride
    		Inhibitor
    Difenoconazole-d6 (hydrochloride) is deuterium labeled Difenoconazole. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
    Difenoconazole-d<sub>6</sub> hydrochloride
  • HY-N8921
    Methoxyanigorufone
    		Inhibitor
    Methoxyanigorufone (compound 4) is a compound that can be isloated from Musa acuminata var. "Yangambi km 5".
    Methoxyanigorufone
  • HY-N15391
    1-Hydroxy-2-nonyn-4-one
    		Inhibitor
    1-hydroxynon-2-yn-4-one is an antibiotic. 1-Hydroxy-2-nonyn-4-one has anti-yeast, filamentous fungus, tumor and weak anti-Gram-positive bacteria and Gram-negative bacteria activity.
    1-Hydroxy-2-nonyn-4-one
  • HY-126644
    Halocyamine B
    		Inhibitor
    Halocyamine B exhibits antimicrobial activity against a variety of bacteria and yeasts. Halocyamine B exhibits cytotoxicity to cultured neural cells of rat fetal brain, mouse neuroblastoma N18 cells, and human hepatoma HepG2 cells.
    Halocyamine B
  • HY-N14877
    Enactin Ia
    		Inhibitor
    Enactin Ia is found in the strain of Streptomyces roseoviridis. Enactin Ia has only weak antifungal activity.
    Enactin Ia
  • HY-23155R
    2-Phenylethyl isothiocyanate (Standard)
    		Inhibitor
    2-Phenylethyl isothiocyanate (Standard) is the analytical standard of 2-Phenylethyl isothiocyanate. This product is intended for research and analytical applications. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternate might be via reduction in toxin content and breakdown of cell membrane integrity.
    2-Phenylethyl isothiocyanate (Standard)
  • HY-B1119R
    Triclosan (Standard)
    		Inhibitor
    Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.
    Triclosan (Standard)
  • HY-P5552
    Melimine
    		Inhibitor
    Melimine is a hybrid antimicrobial peptide of Melittin (HY-P0233) and Protamine. Melimine is active against P. aeruginosa and S. aureus. Melimine has broad spectrum activity against bacteria, fungi and protozoa.
    Melimine
  • HY-N14980
    Dermostatin B
    		Inhibitor
    Dermostatin B is a polyene antibiotic with antifungal activity that can be used in the study of fungal infections.
    Dermostatin B
  • HY-W013780S1
    Fmoc-Pro-OH-13C5,15N
    		Inhibitor
    Fmoc-Pro-OH-13C5,15N is a 15N-labeled and 13C-labled Fmoc-Pro-OH (HY-W013780). Fmoc-Pro-OH is a proline derivative.
    Fmoc-Pro-OH-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N
  • HY-167890
    Flufenoxadiazam
    		Inhibitor
    Flufenoxadiazam is a fungicide. Flufenoxadiazam has potent fungicidal activity, particularly against Phakopsora pachyrhizi and Puccinia triticina.
    Flufenoxadiazam
  • HY-N2789
    (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol
    		Inhibitor
    (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol
  • HY-123002
    Pyrifenox
    		Inhibitor
    Pyrifenox is a fungicide, which is used in fruits, ornamentals, and vegetables. Pyrifenox can be utilized as one of the assessment criteria for environmental and food safety.
    Pyrifenox
  • HY-173206
    Antifungal agent 128
    		Inhibitor
    Antifungal agent 128 (Compound 3ja) is an antifungal agent. When used in combination with Fluconazole (HY-B0101), the MIC range against C. albicans strains is 0.5-4 μg/mL. Antifungal agent 128 can be used in the research of the anti-infection field.
    Antifungal agent 128
  • HY-B2058
    Triticonazole
    		Inhibitor
    Triticonazole is a triazole pesticide. Triticonazole is an azole fungicide and shows endocrine disrupting activities.
    Triticonazole
  • HY-N3344
    Macrocarpal C
    Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular ROS and? induces apoptosis as a consequence of DNA fragmentation.
    Macrocarpal C
  • HY-173528
    Antimicrobial agent-40
    		Inhibitor
    Antimicrobial agent-40 (Compound 5a) has antimicrobial activity against fungi, Gram-negative and Gram-positive bacteria. Antimicrobial agent-40 has good cytotoxicity against MCF-7 cells (IC50: 33.52 μM) and exhibits anticancer activity.
    Antimicrobial agent-40
Cat. No. Product Name / Synonyms Application Reactivity