2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16321R
    Micafungin sodium (Standard)
    		Inhibitor
    Micafungin (sodium) (Standard) is the analytical standard of Micafungin (sodium). This product is intended for research and analytical applications. Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.
    Micafungin sodium (Standard)
  • HY-N15023
    Azoxybacilin
    		Inhibitor
    Azoxybacilin can inhibit the sulfur fixation reaction in methionine biosynthesis and has strong anti-filamentous fungal activity.
    Azoxybacilin
  • HY-106333
    Irtemazole
    		Inhibitor
    Irtemazole is an orally active antifungal agent. Irtemazole possesses uricosuric effect. Irtemazole is used in the research for blastomycosis, histoplasmosis, and aspergillosis.
    Irtemazole
  • HY-118484
    (RS)-Sakuranetin
    		Control
    (RS)-Sakuranetin is the racemate of Sakuranetin (HY-N3006).
    (RS)-Sakuranetin
  • HY-17521R
    Flumorph (Standard)
    		Inhibitor
    Flumorph (Standard) is the analytical standard of Flumorph. This product is intended for research and analytical applications. 0
    Flumorph (Standard)
  • HY-B0293R
    Butoconazole nitrate (Standard)
    		Inhibitor
    Butoconazole (nitrate) (Standard) is the analytical standard of Butoconazole (nitrate). This product is intended for research and analytical applications. Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis.
    Butoconazole nitrate (Standard)
  • HY-165017
    Etheroleic acid
    		Inhibitor
    Etheroleic acid has antifungal activity against the powdery mildew B. graminis on the second leaves of barley seedlings. Etheroleic acid is a metabolite of Linolenic acid.
    Etheroleic acid
  • HY-125358
    Dactylfungin B
    		Inhibitor
    Dactylfungin B (MK 2266 B) is an antifungal antibiotic that is active against Candida pseudotropicalis and other fungi, with an MIC value at <10 μg/mL.
    Dactylfungin B
  • HY-136763
    CYP51-IN-13
    		Inhibitor
    CYP51-IN-2 (compound 1m), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-13
  • HY-118578
    Furalaxyl
    		Inhibitor 99.3%
    Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales.
    Furalaxyl
  • HY-129728
    Lienomycin
    		Inhibitor
    Lienomycin, a polyene antibiotic produced by Actinomyces distatochromogenes var. lienomycini, exhibits antifungal, antibacterial and antitumor activity.
    Lienomycin
  • HY-N14427
    Concanamycin G
    		Inhibitor
    Concanamycin G has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research.
    Concanamycin G
  • HY-W753375R
    Fluindapyr (Standard)
    		Inhibitor
    Clenbuterol (hydrochloride) (Standard) is the analytical standard of Clenbuterol (hydrochloride). This product is intended for research and analytical applications. Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.
    Fluindapyr (Standard)
  • HY-N14489
    Neocopiamycin A
    		Inhibitor
    Neocopiamycin A is broad-spectrum resistant to Gram-positive bacteria, yeast and filamentous fungi.
    Neocopiamycin A
  • HY-119830
    Azaconazole
    		Inhibitor
    Azaconazole is an agriculture fungicide, and can be used for controlling powdery mildew on crops and bean rust.
    Azaconazole
  • HY-133216
    Bupirimate
    		Inhibitor 99.77%
    Bupirimate is a systemic fungicide that inhibits adenosine deaminase (ADA). Bupirimate is widely used in the cultivation of fruit trees, vegetables, flowers, and other crops to control powdery mildew.
    Bupirimate
  • HY-169203
    Antifungal agent 119
    		Inhibitor
    Antifungal agent 119 (compund T23) is an antifungal agent that targets type I reduced NADH oxidoreductase. Antifungal agent 119 carries an azide group and can be used for click chemistry reactions..
    Antifungal agent 119
  • HY-133216R
    Bupirimate (Standard)
    		Inhibitor
    Bupirimate (Standard) is the analytical standard of Bupirimate (HY-133216). This product is intended for research and analytical applications. Bupirimate is a systemic fungicide that inhibits adenosine deaminase (ADA). Bupirimate is widely used in the cultivation of fruit trees, vegetables, flowers, and other crops to control powdery mildew.
    Bupirimate (Standard)
  • HY-173448
    CDA-IN-4
    		Inhibitor
    CDA-IN-4 (compound VS-24) is a chitin deacetylase (CDA) inhibitor. CDA-IN-4 shows a 61.2% protective effect against rice blast at a concentration of 100 μg/mL.
    CDA-IN-4
  • HY-N14582
    Glomosporin
    		Inhibitor
    Glomosporin is a cyclic ester peptide antifungal antibiotic, and it has moderate anti-Aspergillus flavus (including Aspergillus Niger and Aspergillus Niger), yeast activity (MIC is 16 μg/mL).
    Glomosporin
Cat. No. Product Name / Synonyms Application Reactivity