Ferroptosis

Related Products

Ferroptosis is a non-apoptotic form of regulated cell death. It is distinct from other regulated cell death phenotypes, such as apoptosis and necroptosis. Ferroptosis is characterized by extensive lipid peroxidation, which can be suppressed by iron chelators or lipophilic antioxidants. Mechanistically, Ferroptosis inducers are divided into two classes: (1) inhibitors of cystine import via system x_c⁻ (e.g., Erastin), which subsequently causes depletion of glutathione (GSH), and (2) covalent inhibitors (e.g., (1S, 3R)-RSL3) of glutathione peroxidase 4 (GPX4). Since GPX4 reduces lipid hydroperoxides using GSH as a co-substrate, both compound classes ultimately result in loss of GPX4 activity, followed by elevated levels of lipid reactive oxygen species (ROS) and consequent cell death.

Ferroptosis is an iron- and ROS-dependent form of regulated cell death (RCD). Misregulated Ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity.

Ferroptosis Related Products (541)
Antibodies (6)
Related Compound Screening Libraries (1)
Ferroptosis Signaling Pathway

By Effects:	Controls (4) Inhibitors (238) Agonists (2) Activators (136) Inducers (119)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0450S

Ciclopirox-d₁₁	Inhibitor
Ciclopirox-d₁₁ is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic.

HY-161972

ZX782	Inducer
ZX782 is a Hty-type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination. ZX782 is composed of target protein ligand (red part) ML-210 (HY-100003), PROTAC linker (black part) Bromo-PEG2-CH2-Boc (HY-141371) and Hty molecule (blue part) Adamantan-1-ylmethanamine (HY-W037848). The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br (HY-161974), and the activity control of the target protein ligand is Hydroxyl-ML-210 (HY-161973).

HY-14664AR

Fluvastatin sodium (Standard)	Activator
Fluvastatin (sodium) (Standard) is the analytical standard of Fluvastatin (sodium). This product is intended for research and analytical applications. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-W020044S

DL-alpha-Tocopherol-¹³C₃	Inhibitor
DL-alpha-Tocopherol-¹³C₃ is the ¹³C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB.

HY-14655R

Sulfasalazine (Standard)	Activator
Sulfasalazine (Standard) is the analytical standard of Sulfasalazine. This product is intended for research and analytical applications. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer.

HY-106376R

DL-Buthionine-(S,R)-sulfoximine (Standard)	Activator
DL-Buthionine-(S,R)-sulfoximine (Standard) is the analytical standard of DL-Buthionine-(S,R)-sulfoximine. This product is intended for research and analytical applications. DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

HY-N0001S2

(-)-Epicatechin-¹³C₃	Activator
(-)-Epicatechin-¹³C₃ ((-)-Epicatechol-¹³C₃) is ¹³C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N2065R

Withaferin A (Standard)	Activator
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-50898R

Lapatinib (Standard)	Activator
Lapatinib (Standard) is the analytical standard of Lapatinib. This product is intended for research and analytical applications. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.

HY-50898CS

Lapatinib-d₄ tosylate	Activator
Lapatinib-d₄ (GW572016-d₄) tosylate is deuterium labeled Lapatinib (tosylate). Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.

HY-14655S1

Sulfasalazine-d₃,¹⁵N	Activator
Sulfasalazine-d₃,¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer.

HY-17386AR

Rosiglitazone hydrochloride (Standard)	Inhibitor
Rosiglitazone (hydrochloride) (Standard) is the analytical standard of Rosiglitazone (hydrochloride). This product is intended for research and analytical applications. Rosiglitazone (BRL 49653) hydrochloride is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone hydrochloride is a TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone hydrochloride can be used in the research of obesity and diabetes, senescence, ovarian cancer.

HY-14291R

Vildagliptin (Standard)	Inhibitor
Vildagliptin (Standard) is the analytical standard of Vildagliptin. This product is intended for research and analytical applications. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.

HY-N0196R

Baicalein (Standard)	Inhibitor
Baicalein (Standard) is the analytical standard of Baicalein. This product is intended for research and analytical applications. Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.

HY-N0504S

Epi lovastatin-d₃
Epi Lovastatin-d₃ is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-N0683S6

α-Vitamin E-d₁₁	Inhibitor
α-Vitamin E-d11 ((+)-α-Tocopherol-d11) is the deuterium labeled α-Vitamin E (HY-N0683). α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant.

HY-50898BR

Lapatinib ditosylate monohydrate (Standard)	Activator
Lapatinib (ditosylate monohydrate) (Standard) is the analytical standard of Lapatinib (ditosylate monohydrate). This product is intended for research and analytical applications. Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.

HY-B0451AS6

Dopamine-¹³C,¹⁵N hydrochloride	Inducer	99.02%
Dopamine-¹³C,¹⁵N (hydrochloride) is the ¹³C and ¹⁵N labeled Dopamine hydrochloride.

HY-N15398

Chaetoglobosin E	Inducer
Chaetoglobosin E is a Ferroptosis inducer that exhibits significant cytotoxicity against human tumor cell lines MDA-MB231 and A549, with IC₅₀ values of 9.14 and 7.47 μM, respectively. By downregulating the expression of GPX4 in A549 cells, Chaetoglobosin E markedly increases intracellular levels of Fe²⁺ and the lipid peroxidation product malondialdehyde (MDA), leading to mitochondrial shrinkage, reduction or disappearance of cristae, and subsequent induction of ferroptosis. Chaetoglobosin E can be used for research in the field of cancer.

HY-163995

GPX4-IN-13	Inducer
GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC₅₀=8.39 μM), MDA-T32 (IC₅₀=10.28 μM) and MDA-T41 (IC₅₀=8.18 μM).

Ferroptosis Compound Library

Compound library targeting ferroptosis signaling pathways.

957compounds HY-L051

Cystine NOX1 DPP4 Glutamine Tf Methionine Homocysteine p53 CBS Cystathionine Cystine CTH GCLC ABCA1 SREBP2 G6PD γ-glutamylcysteine GSS Ac-CoA HMG-CoA HMGCR Mevalonate Isopentenyl-PP Farnesyl-PP Squalene Squalene-2,3-epoxide Cholesterol FDFT1 SQLE AIFM2 NADPH GSH CDKN1A Se GPX4 Se p21 p53 NRF2 KEAP1 p62 CoQ10 PRDX CHMP5 AKR1Cs CHMP6 ESCRT-Ⅲ Lipid ROS PRDX PRDX GLS2 Glutamine VDAC2/3 GOT1 αKG Fumarate Succinate OXPHOS Citrate Malate ROS ACL Ac-CoA NCOA4 Ferritinophagy Iron Import FTH1 FTL Storage Endosome STEAPs ACACA RAB7A FASN Mal-CoA Fatty Acid Lipophagy Lible iron pool Ferritinophagy STEAP3 NCOA4 Ferritin LDs Storage AA/AdA Ferroptocide TXN PRDX ROS ACSL4 AA/AdA-CoA LPCAT3 AA/AdA-PE TPD52 CAV1 TXN POR ALOXs HMOX1 Heme Fenton
reaction ROS PEX10 PEX3 PUFA-plasmalogen Peroxisome Lysosome CTSB DNA damage/H3 cleavage Membrane oxidative damage Ferroptosis RNS p53 BAP1

Download Ferroptosis Signaling Pathway Map.

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Ferroptosis

Ferroptosis

Ferroptosis Related Products (541)

Antibodies (6)

Related Compound Screening Libraries (1)

Ferroptosis Signaling Pathway

Ferroptosis Related Products (541):