Cathepsin

Cathepsin Related Products (145):

By Effects:	Control (1) Inhibitors (106) Agonist (1) Activators (3) Inducer (1)

Cat. No.	Product Name	Effect	Purity

HY-17541

Cysteine Protease inhibitor	Inhibitor
Cysteine Protease inhibitor is an inhibitor of cysteine protease.

HY-P1759B

N-CBZ-Phe-Arg-AMC TFA		99.95%
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.

HY-146584

Cathepsin C-IN-5	Inhibitor
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity.

HY-108137

Z-LVG-CHN2	Inhibitor	99.88%
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease.

HY-129578

Asperphenamate	Inhibitor	≥98.0%
Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC₅₀ values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively.

HY-141867

Z-FF-FMK	Inhibitor	98.71%
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation.

HY-P1315

Papain inhibitor	Inhibitor	99.60%
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a K_i of 9 μM at pH 6.2.

HY-149482

LN5P45	Inhibitor	99.05%
LN5P45 is an OTUB2 inhibitor (IC₅₀: 2.3 μM). LN5P45 induces monoubiquitination of OTUB2 on lysine 31. LN5P45 can be used for research of tumor progression and metastasis.

HY-P4515

Z-Phe-Arg-pNA		99.95%
Z-Phe-Arg-pNA is a substrate of Cathepsin L.

HY-155667A

Z-Nle-Lys-Arg-AMC acetate		99.58%
Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range.

HY-115454A

GB111-NH2 hydrochloride	Inhibitor	99.26%
GB111-NH2 hydrochloride is a cysteine cathepsin inhibitor, and can be used for cancer study.

HY-P4295

Z-Phe-Ala-diazomethylketone	Inhibitor
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research.

HY-N4288

4-Methylesculetin	Inhibitor	98.09%
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases.

HY-D1634

Bz-FVR-AMC		99.83%
Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a k_cat/K_m value of 1070 mM^-1s^-1. The high concentration of BZ-FVR-AMC inhibits the substrate.

HY-P2498A

Cathepsin D and E FRET Substrate acetate		99.78%
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D.

HY-153986

AEP-IN-2	Inhibitor	99.13%
AEP-IN-2 is an asparagine endopeptidase (AEP) inhibitor via block AEP cleavage of APP and Tau. AEP-IN-2 has oral activity and decreases Aβ40 and Aβ42 and p-Tau levels .

HY-137841

L-Arginine-7-amido-4-methylcoumarin hydrochloride		99.23%
L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B.

HY-W790014

Z-FG-NHO-BzOME	Inhibitor	98.14%
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain.

HY-P4340A

Arg-Arg-AMC acetate		99.93%
Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC (HY-P4340). Arg-Arg-AMC acetate is a fluorescent substrate for cathepsin B and used in the cathepsin B activity assay.

HY-137367

Z-Val-Val-Arg-AMC		99.77%
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins.

Name
Email *

	Sorry, but the email address you supplied was invalid.