2. Signaling Pathways
  3. Anti-infection
  4. CMV

CMV

Cytomegalovirus

CMV

Related Products

PDF 0.14 MB

Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the ubiquitous family of herpesviruses. Cytomegaloviruses escape immunological clearance and persist throughout life in the infected host. Yet, the stability of the balance of this virus-host interaction is dependent upon the state of the cellular immune response, and usually requires the function of specific CD8 T lymphocytes.

Human cytomegalovirus is a member of the viral family known as herpesviruses, Herpesviridae, or human herpesvirus-5 (HHV-5). Human cytomegalovirus infections commonly are associated with the salivary glands. CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer.

CMV Related Products (75):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162690
    DNA polymerase-IN-5
    		Inhibitor
    DNA polymerase-IN-5 (compound 42) is a broad-spectrum herpes antiviral. DNA polymerase-IN-5 against both CMV and VZV infection with IC50 values of 6.6 and 4.8 μM.
    DNA polymerase-IN-5
  • HY-N1127S
    Tricin-d6
    Tricin-d6 is the deuterium labeled Tricin. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.
    Tricin-d<sub>6</sub>
  • HY-147014
    Cyclic HPMPC
    		Inhibitor
    Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model.
    Cyclic HPMPC
  • HY-N0093A
    Ancitabine
    		Inhibitor
    Ancitabine is the precursor of the anticancer agent Cytarabine (HY-13605), which targets targets related to cell metabolism and proliferation. Ancitabine can inhibit tumor cell proliferation, interfere with the DNA synthesis process of tumor cells, and prevent cell division. Under alkaline pH conditions, Ancitabine can be quantitatively converted into Cytarabine and can be used in the study of cancers such as colorectal cancer.
    Ancitabine
  • HY-A0032AS
    Valganciclovir-d8 hydrochloride
    Valganciclovir-d8 (hydrochloride) is the deuterium labeled Valganciclovir hydrochloride. Valganciclovir hydrochloride, the L-valyl ester of ganciclovir, is actually a proagent for ganciclovir.
    Valganciclovir-d<sub>8</sub> hydrochloride
  • HY-P1780
    CEF20
    CEF20 is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
    CEF20
  • HY-19296
    BDCRB
    		Inhibitor
    BDCRB is a selective Human cytomegalovirus (HCMV) inhibitor through blocking the maturational cleavage of high-molecular-weight DNA. BDCRB shows a mean IC50 of 0.03 μM for viral yield at 72 h postinfection.
    BDCRB
  • HY-N1127R
    Tricin (Standard)
    		Inhibitor
    Tricin (Standard) is the analytical standard of Tricin. This product is intended for research and analytical applications. Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .
    Tricin (Standard)
  • HY-P10509
    IE1 peptide
    		Inhibitor
    IE1 peptide refers to an antigenic peptide encoded by the immediate early (IE) gene of mouse cytomegalovirus (mCMV). IE1 peptide is one of the key antigenic peptides expressed during mCMV infection, plays a role in transcriptional activation in the life cycle of mCMV, and is one of the earliest genes expressed in the viral replication cycle. IE1 peptide is an important target for CD8+ T cell response and can be used to study the host immune response to mCMV infection.
    IE1 peptide
  • HY-W766548
    Floxuridine-13C,15N2
    Floxuridine-13C,15N2 (5-Fluorouracil 2'-deoxyriboside-13C,15N2) is the 13C- and 15N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV.
    Floxuridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-15233G
    Letermovir (GMP)
    		Inhibitor
    Letermovir (GMP) is the GMP grade of Letermovir (HY-15233). Letermovir (GMP) is an orally active CMV inhibitor. Letermovir (GMP) targets the CMV terminase complex rather than CMV DNA polymerase and exerts its antiviral activity. Letermovir (GMP) can be used in the study of CMV infection.
    Letermovir (GMP)
  • HY-114005
    SB-734117
    		Inhibitor
    SB-734117 is a human cytomegalovirus (HCMV) replication inhibitor that prevents CREB and histone H3 post-translational modifications.
    SB-734117
  • HY-160917
    BAY-43-9695
    		Inhibitor
    BAY-43-9695 is a nonnucleosidic with activity against human cytomegalovirus (hCMV) with IC50 of 0.95 and 1.1 μM, using the FACS and PRA methodes. BAY-43-9695 inhibits the HCMV replication with and without presence of serum proteins, with IC50 of 0.53 and 8.42 μM. BAY-43-9695 is the metabolite of Tomeglovir (BAY38-4766) (HY-108261).
    BAY-43-9695
  • HY-P10685
    T-22
    		Inhibitor
    T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an EC50 of 0.008 μg/mL and a CC50 of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV.
    T-22
  • HY-A0032S
    Valganciclovir-d5 TFA
    Valganciclovir-d5 (TFA) is the deuterium labeled Valganciclovir TFA. Valganciclovir, the L-valyl ester of ganciclovir, is actually a proagent for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.
    Valganciclovir-d<sub>5</sub> TFA
  • HY-A0032AR
    Valganciclovir hydrochloride (Standard)
    		Inhibitor
    Valganciclovir (hydrochloride) (Standard) is the analytical standard of Valganciclovir (hydrochloride). This product is intended for research and analytical applications. Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus.
    Valganciclovir hydrochloride (Standard)
  • HY-41343
    Triacetyl-ganciclovir
    		Inhibitor
    Triacetyl-ganciclovir is a Ganciclovir derivative. Ganciclovir is an orally active antiviral agent with activity against cytomegalovirus (CMV).
    Triacetyl-ganciclovir
  • HY-105098
    Lobucavir
    		Inhibitor
    Lobucavir (BMS-180194; SQ 34514)，a nucleoside analogue，is an antiviral agent. Lobucavir shows a broad spectrum of activity against HBV，HIV/AIDS，and α，β，and γ herpes viruses including CMV，herpes-simplex，varicella-zoster，and Epstein-Barr virus.
    Lobucavir
  • HY-167911
    Cidofovir sodium
    		Inhibitor
    Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities.
    Cidofovir sodium
  • HY-128370
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate
    		Inhibitor ≥98.0%
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication.
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate