2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-103114
    AT1015 hydrochloride 190508-50-0 98%
    AT1015 hydrochloride is a potent antagonist of 5-HT2 receptor, with the pKi of 7.94. AT1015 inhibits vasoconstriction and blocks platelet aggregation.
    AT1015 hydrochloride
  • HY-103115
    Pruvanserin hydrochloride 443144-27-2 98%
    Pruvanserin hydrochloride (EMD 281014) is a selective serotonin 5-HT2A receptor antagonist with IC50 values of 0.35 nM and 1 nM for human and rat 5-HT2A receptors. Pruvanserin (hydrochloride) can be used for the research of schizophrenia.
    Pruvanserin hydrochloride
  • HY-103117
    S 32212 hydrochloride 847871-78-7 98%
    S 32212 hydrochloride is an inverse agonist of 5-HT receptors 5-HT2(CINI) and 5-HT2(CVSV) (Kis=6.6, 8.9 nM) and an antagonist of 5-HT2A and α2β-adrenergic receptors (Ki=5.8, 5.8 nM). S 32212 hydrochloride can reduce the binding of GTPγS to Gαq, and reduce the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2(CINI) receptor and CHO cells expressing 5-HT2(CVSV) receptor (EC50=38 and 18.6 nM, respectively). S 32212 hydrochloride (2.5 mg/kg) reduces 5-HT receptor agonist-induced head twitches and penile erections in mice and rats. S 32212 hydrochloride (10, 40 mg/kg) reduces immobility time in the forced swim test and marble burying behavior in mice and rats, exerting antidepressant and anxiolytic activities.
    S 32212 hydrochloride
  • HY-103120
    Org37684 213007-95-5 98%
    Org37684 is a highly potent 5-HT2C receptor agonist (pEC50=8.17). Org37684 exhibits a rank order of potency of 5-HT2C>5-HT2B>5-HT2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC50=7.96) and ten times for the 5-HT2A (pEC50=7.11) receptor.
    Org37684
  • HY-103123
    SB 258719 hydrochloride 1217674-10-6 98%
    SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases.
    SB 258719 hydrochloride
  • HY-103126
    DR4485 hydrochloride 402942-53-4 98%
    DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14).
    DR4485 hydrochloride
  • HY-103132
    PNU109291 187665-60-7 98%
    PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.
    PNU109291
  • HY-103138
    (Rac)-WAY-161503 hydrochloride 276695-22-8 98%
    (Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects.
    (Rac)-WAY-161503 hydrochloride
  • HY-103144
    WAY 629 hydrochloride 57756-44-2 98%
    WAY 629 hydrochloride is a potent and selective 5-HT2C agonist with EC50s of 426, 260000 nM for 5-HT2C and 5-HT2A, respectively. WAY 629 hydrochloride decreases feeding behavior.
    WAY 629 hydrochloride
  • HY-103146
    GR125487 sulfamate 859502-43-5 98%
    GR125487 sulfamate is an orally active and selective antagonist of 5-HT4R. GR125487 sulfamate effectively blocks the cognition enhancing effect. GR125487 sulfamate can be used to study memory disorders, gastrointestinal disorders, mood disorders and urinary tract dysfunction.
    GR125487 sulfamate
  • HY-103147
    Mesulergine hydrochloride 72786-12-0 98%
    Mesulergine (CU32-085) hydrochloride is a potent 5-HT2C antagonist and dopamine (DA) agonist. Mesulergine hydrochloride presentes hyperphagia. Mesulergine hydrochloride has the potential for the research of cognitive processes.
    Mesulergine hydrochloride
  • HY-103148
    LY215840 137328-52-0 98%
    LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery.
    LY215840
  • HY-103155
    SB-221284 196965-14-7 98%
    SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease.
    SB-221284
  • HY-103199
    Carpindolol 39731-05-0 98%
    Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37).
    Carpindolol
  • HY-103216
    RWJ52353 245744-10-9 98%
    RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with Kis of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED50 of 15.1 mg/kg.
    RWJ52353
  • HY-103217
    Talopram hydrochloride 7013-41-4 98%
    Talopram hydrochloride is a selective inhibitor for norepinephrine transporter (NET), that inhibits 63% human NET at 100 nM.
    Talopram hydrochloride
  • HY-103218
    Talsupram hydrochloride 25487-28-9 98%
    Talsupram (hydrochloride) is a selective norepinephrine inhibitor with high affinity for norepinephrine transporter (NET) and can be used in the study of neuropathic pain.
    Talsupram hydrochloride
  • HY-103225
    S-8510 phosphate 151466-23-8 98%
    S-8510 (phosphate) is an inverse Benzodiazepine (BDZ) receptor agonist, with Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively.
    S-8510 phosphate
  • HY-103232
    IEM-1925 bromide 258282-23-4 98%
    IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy.
    IEM-1925 bromide
  • HY-103234
    GYKI 52466 102771-26-6 98%
    GYKI 52466 is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 can be used in Parkinson's disease research.
    GYKI 52466
Cat. No. Product Name / Synonyms Application Reactivity