2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0761
    (R,R)-Glycopyrrolate 475468-09-8 98%
    (R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) is an anticholinergic agent. (R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) has the ability to reduce the frequency of drooling in vivo with developmental disabilities.
    (R,R)-Glycopyrrolate
  • HY-B0768
    Lomerizine 101477-55-8 98%
    Lomerizine is an antagonist of L- and T-type voltagegated calcium channels.
    Lomerizine
  • HY-B0773
    Paroxetine mesylate 217797-14-3 98%
    Paroxetine mesylate, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine mesylate is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs.
    Paroxetine mesylate
  • HY-B0950
    Mefexamide 1227-61-8 98%
    Mefexamide hydrochloride is a particular psychostimulant that is capable of reversing the psychodepressant effects induced by diazepam and benzodiazepine sedatives.
    Mefexamide
  • HY-B1219
    Pentolinium tartrate 52-62-0
    Pentolinium tartrate is a ganglionic blocking agent. Pentolinium tartrate lowers blood pressure and permits regression of the signs and symptoms associated with severe hypertension.
    Pentolinium tartrate
  • HY-B1316
    Trimetozine 635-41-6 99.73%
    Trimetozine is an orally active sedative. Trimetozine has mild tranquilizing effects. Trimetozine can be used for the research of anxiety.
    Trimetozine
  • HY-B1423
    Lobeline 90-69-7 98%
    Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation.
    Lobeline
  • HY-B1482
    Mesoridazine benzenesulfonate 32672-69-8 98%
    Mesoridazine (TPS-23) benzenesulfonate, a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine benzenesulfonate is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells.Mesoridazine benzenesulfonate can be used for the research of schizophrenia, as well as certain other psychiatric disorders.
    Mesoridazine benzenesulfonate
  • HY-B1495
    Quipazine maleate 5786-68-5 98%
    Quipazine maleate is a 5-HT agonist that causes behavioural changes such as hyperactivity. Quipazine maleate also shows a weak reversible MAO inhibitory activity.
    Quipazine maleate
  • HY-B1543
    Benmoxin 7654-03-7 98%
    Benmoxin is a monoamine oxidase (MAO) inhibitor. Benmoxin is used in depression research.
    Benmoxin
  • HY-B1546
    Benzamil 2898-76-2 98%
    Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
    Benzamil
  • HY-B1558
    Bifemelane 90293-01-9 98%
    Bifemelane is a nootropic compound. Bifemelan causes the first peak by stimulating release from intracellular Ca2+ stores and the second by capacitive entry through store–operated Ca2+ channels. Bifemelane will be provided as a pharmacological tool for basic studies on astrocytes.
    Bifemelane
  • HY-B1562
    Bopindolol 62658-63-3 98%
    Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
    Bopindolol
  • HY-B1585
    Caramiphen 77-22-5
    Parpanil is an anticholinergic agent with NMDA receptor antagonist activity. Parpanil can be used to inhibit diseases related to cholinergic neurotransmission. Parpanil exerts its pharmacological effects by blocking cholinergic effects.
    Caramiphen
  • HY-B1589
    (±)-Carbinoxamine 486-16-8 98%
    (±)-Carbinoxamine is a histamine H1 receptor antagonist.
    (±)-Carbinoxamine
  • HY-B1594
    Carbromal 77-65-6 98%
    Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects.
    Carbromal
  • HY-B1656
    Fomocaine 17692-39-6 98%
    Fomocaine (P 652) is an orally active local agent that can suppress or relieve pain. Fomocaine shows antiarrhythmic activity.
    Fomocaine
  • HY-B1657
    Fosphenytoin 93390-81-9 98%
    Fosphenytoin is a phosphate ester proagent developed as an alternative to intravenous phenytoin for acute intervention of seizures. Fosphenytoin has advantages including more convenient and rapid intravenous administration, availability for intramuscular injection, and low potential for adverse local reactions at injection sites.
    Fosphenytoin
  • HY-B1658
    Frovatriptan 158747-02-5 98%
    Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura.
    Frovatriptan
  • HY-B1665
    Isobutamben 94-14-4
    Isobutamben is an amino ester-type local anaesthetic agent.
    Isobutamben
Cat. No. Product Name / Synonyms Application Reactivity