2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-139509S
    Capsiamide-d3 1795031-33-2 98%
    Capsiamide-d3 is the deuterium labeled Capsiamide.
    Capsiamide-d3
  • HY-14545S1
    Amisulpride-d5 N-Oxide 1794756-15-2 98%
    Amisulpride-d5 N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
    Amisulpride-d5 N-Oxide
  • HY-14546S1
    Aripiprazole (1,1,2,2,3,3,4,4-d8) 1089115-04-7 98%
    Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
    Aripiprazole (1,1,2,2,3,3,4,4-d8)
  • HY-17034BS
    Medetomidine-d3 hydrochloride 1246820-20-1 98%
    Medetomidine-d3 (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor.
    Medetomidine-d3 hydrochloride
  • HY-17038S1
    Agomelatine-d4 1079389-44-8 98%
    Agomelatine-d4 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
    Agomelatine-d4
  • HY-B0176AS
    rel-Sertraline-d3 hydrochloride 1330180-66-9 98%
    rel-Sertraline-d3 (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.
    rel-Sertraline-d3 hydrochloride
  • HY-B0189S1
    Mosapride-d5 1246820-66-5 98%
    Mosapride-d5 is the deuterium labeled Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
    Mosapride-d5
  • HY-B0246S1
    Carbamazepine-d2 1189902-21-3 98%
    Carbamazepine-d2 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent.
    Carbamazepine-d2
  • HY-B0274AS
    Chlorprothixene-d6 hydrochloride 98%
    Chlorprothixene-d6 hydrochloride is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity.
    Chlorprothixene-d6 hydrochloride
  • HY-B0383AS
    Almotriptan hydrochloride-d6 1794782-57-2 98%
    Almotriptan-d6 hydrochloride is the deuterium labeled Almotriptan. Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine.
    Almotriptan hydrochloride-d6
  • HY-B0457S1
    Clomipramine-d6 hydrochloride 1189882-28-7 98%
    Clomipramine-d6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD).
    Clomipramine-d6 hydrochloride
  • HY-B0524AS
    Betahistine-d3 dihydrochloride 244094-72-2 ≥99.0%
    Betahistine-d3 (dihydrochloride) is the deuterium labeled Betahistine dihydrochloride. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).
    Betahistine-d3 dihydrochloride
  • HY-N0168AS
    (Rac)-Hesperetin-d3 1346605-26-2 98%
    (Rac)-Hesperetin-d3 is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
    (Rac)-Hesperetin-d3
  • HY-108506S1
    Licarbazepine-d4 1020719-39-4 98%
    Licarbazepine-d4 is the deuterium labeled Licarbazepine (HY-108506). Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects.
    Licarbazepine-d4
  • HY-B0121BS1
    Sumatriptan-d6 1020764-38-8 98%
    Sumatriptan-d6 is the deuterium labeled Sumatriptan. Sumatriptan is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan can be used for migraine headache research.
    Sumatriptan-d6
  • HY-W013425S
    2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 1331662-16-8 98%
    2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 is the deuterium labeled 2-Hydroxy-5-(phenyldiazenyl)benzoic acid.
    2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5
  • HY-W012722BS
    4-Methyl-2-oxopentanoic acid-d7 sodium 1795020-84-6 98%
    4-Methyl-2-oxopentanoic acid-d7 (α-Ketoisocaproic acid-d7) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways.
    4-Methyl-2-oxopentanoic acid-d7 sodium
  • HY-10030
    Mardepodect succinate 1037309-45-7 98%
    Mardepodect succinate (PF-2545920 succinate) is a potent and specific phosphodiesterase 10A (PDE10A) inhibitor with potential activity in the treatment of schizophrenia. Mardepodect succinate has been further optimized to improve brain penetration and compound-like properties for use in schizophrenia research.
    Mardepodect succinate
  • HY-10049
    CP 122721 145742-28-5 98%
    CP 122721 is an orally active NK1 receptor antagonist. CP 122721 attenuates cisplatin-induced vomiting in ferrets (ID50: 0.08 mg/kg). CP 122721 inhibits kainate (KA)-induced seizure activity and CA1 neuronal cell death in rats. CP 122721 is useful in the study of depression, asthma, and irritable bowel syndrome (IBS).
    CP 122721
  • HY-10051
    GR203040 168398-02-5 98%
    GR203040 is an orally active NK1 receptor antagonist with a pKi of 10.3. GR203040 shows potent antiemetic activity.
    GR203040
Cat. No. Product Name / Synonyms Application Reactivity