2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0298AS
    Clemastine-d5 fumarate 99.48%
    Clemastine-d5 (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
    Clemastine-d5 fumarate
  • HY-B0304AS
    Dapoxetine-d7 hydrochloride 2699607-47-9 99.92%
    Dapoxetine-d7 (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI).
    Dapoxetine-d7 hydrochloride
  • HY-B0573S1
    Propranolol-d7 (ring-d7) 344298-99-3 99.38%
    Propranolol-d7 (ring-d7) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
    Propranolol-d7 (ring-d7)
  • HY-N0229S1
    L-Alanine-1-13C 21764-56-7 ≥99.0%
    L-Alanine-1-13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1-13C
  • HY-N0229S8
    L-Alanine-13C3 100108-77-8 98%
    L-Alanine-13C3 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-13C3
  • HY-N0229S9
    L-Alanine-13C2 65163-26-0 ≥98.0%
    L-Alanine-13C2 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-13C2
  • HY-N0304S2
    L-DOPA-13C 586971-29-1 ≥98.0%
    L-DOPA-13C is the 13C labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
    L-DOPA-13C
  • HY-N0473S5
    L-Tyrosine-4-13C 81201-90-3 99.80%
    L-Tyrosine-4-13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-4-13C
  • HY-N0473S7
    L-Tyrosine-1-13C 81201-89-0 ≥98.0%
    L-Tyrosine-1-13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-1-13C
  • HY-N0680S1
    Thiamine-d3 hydrochloride 2241872-28-4 ≥98.0%
    Thiamine-d3 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.
    Thiamine-d3 hydrochloride
  • HY-P10936A
    AQP4 (201-220) TFA 98.01%
    AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica.
    AQP4 (201-220) TFA
  • HY-P990081
    Oloctinebart 2669063-84-5 98.00%
    Oloctinebart is a humanized immunoglobulin G4-kappa, anti-LGALS3 monoclonal antibody. Oloctinebart is used for reduction of amyloid beta oligomers formation.
    Oloctinebart
  • HY-W002299
    Boc-D-Leucine monohydrate 200937-17-3 99.59%
    Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect.
    Boc-D-Leucine monohydrate
  • HY-W005637
    Orthocaine 536-25-4 99.81%
    Orthocaine is a local agent that can suppress or relieve pain (extracted from patent WO2002089849A1).
    Orthocaine
  • HY-W010513
    3-Methylvaleric Acid 105-43-1 99.39%
    3-Methylvaleric Acid is a branched alkanoic acid. 3-Methylvaleric Acid can be utilized by Pseudomonas citronettotis as a sole carbon source for its growth. 3-Methylvaleric Acid derivatives exhibit anti-hyperalgesic and anticonvulsant activities.
    3-Methylvaleric Acid
  • HY-W011246
    Velnacrine maleate 118909-22-1 ≥98.0%
    Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.
    Velnacrine maleate
  • HY-W013058
    Decabromodiphenyl ethane 84852-53-9 ≥98.0%
    Decabromodiphenyl ethane (DBDPE; 1,2-Bis(perbromophenyl)ethane) is a brominated flame retardant. Decabromodiphenyl ethane can exhibit neurotoxicity, thyroid toxicity, reproductive developmental toxicity, hepatotoxicity, and oxidative stress in living organisms.
    Decabromodiphenyl ethane
  • HY-W013788
    2-Palmitoylglycerol 23470-00-0 ≥99.0%
    2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119.
    2-Palmitoylglycerol
  • HY-W015026
    Isobutylparaben 4247-02-3 98.87%
    Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics.
    Isobutylparaben
  • HY-W015595
    L-Allylglycine hydrochloride 195316-72-4 ≥98.0%
    L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity.
    L-Allylglycine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity