2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-153617
    FOXO1-IN-3 2451093-95-9 99.05%
    FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain.
    FOXO1-IN-3
  • HY-162351
    EBP-IN-1 99.67%
    EBP-IN-1 (compound 11) is an inhibitor of emopamil-binding protein (EBP), a sterol isomerase in the cholesterol biosynthetic pathway. EBP-IN-1 has a long half-life in rodents and has good metabolic turnover and brain penetration properties. EBP-IN-1 enhances oligodendrocyte formation in human cortical organoids.
    EBP-IN-1
  • HY-N0182R
    Fisetin (Standard) 528-48-3 98.47%
    Fisetin (Standard) is the analytical standard of Fisetin. This product is intended for research and analytical applications. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
    Fisetin (Standard)
  • HY-P1465A
    Secretin (28-54), human TFA 98.62%
    Secretin (28-54), human TFA is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.
    Secretin (28-54), human TFA
  • HY-113143A
    Galactose 1-phosphate Potassium salt 19046-60-7 ≥99.0%
    Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.
    Galactose 1-phosphate Potassium salt
  • HY-W011689
    6PPD 793-24-8 99.44%
    6PPD is a rubber antioxidant that scavenges ozone, forming nitroxyl radicals. 6PPD exposure decreases hatchability, lowered autonomous movement, reduces body length in zebrafish embryos and causes deformities. 6PPD also produces oxidative stress in zebrafish embryos.
    6PPD
  • HY-W014180
    N-Acetyl-L-histidine monohydrate 39145-52-3
    N-Acetyl-L-histidine monohydrate, a histidine derivative, is a prominent biomolecule in brain, retina and lens of poikilothermic vertebrates. N-Acetyl-L-histidine monohydrate has a role as an animal metabolite.
    N-Acetyl-L-histidine monohydrate
  • HY-W016009
    2'-Deoxyadenosine-5'-monophosphate 653-63-4 ≥99.0%
    2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate
  • HY-W017163
    7-Methylxanthine 552-62-5 ≥99.0%
    7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity.
    7-Methylxanthine
  • HY-W018026
    Oxfenicine 32462-30-9 99.76%
    Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases.
    Oxfenicine
  • HY-W020215
    Tricarballylic acid 99-14-9 ≥98.0%
    Tricarballylic acid is an orally active compound that can be produced by rumen microorganisms and has the activity of chelating magnesium. Tricarballylic acid is also a competitive inhibitor of aconitate hydratase, with a Ki value of 0.52 mM. Tricarballylic acid can inhibit the oxidation of acetate in the citric acid cycle and can be used in the research of ruminant tissue metabolism and grass tetany syndrome. In addition, Tricarballylic acid can be used to synthesize specific complexes and produce plasticizers.
    Tricarballylic acid
  • HY-W048838
    Acetyl-L-lysine 1946-82-3 ≥98.0%
    Acetyl-L-lysine is an acetylated form of the amino acid L-lysine. Acetyl-L-lysine can participate in protein acylation processes, affecting protein functions such as stability and enzyme activity.
    Acetyl-L-lysine
  • HY-111431AS
    p-Cresol sulfate-d7 potassium 2469278-96-2 ≥98.0%
    p-Cresol sulfate-d7 (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2].
    p-Cresol sulfate-d7 potassium
  • HY-W019981C
    Magnesium chloride hexahydrate, for cell culture 7791-18-6
    Magnesium chloride hexahydrate (MgCl2 hexahydrate), for cell culture is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate, for cell culture can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate, for cell culture increases the activity of Ca2+ ATPase.
    Magnesium chloride hexahydrate, for cell culture
  • HY-N1428A
    Citric acid monohydrate 5949-29-1 ≥98.0%
    Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid monohydrate
  • HY-113273A
    Diadenosine pentaphosphate pentasodium 4097-04-5
    Diadenosine pentaphosphate pentasodium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes.
    Diadenosine pentaphosphate pentasodium
  • HY-12525
    LGD-6972 1207989-09-0 ≥98.0%
    LGD-6972 is a selective and orally active glucagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.
    LGD-6972
  • HY-15497
    AZD7687 1166827-44-6 99.80%
    AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research.
    AZD7687
  • HY-121515
    DPM-1001 1471172-27-6
    DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property.
    DPM-1001
  • HY-129571
    BioE-1115 1268863-35-9 99.56%
    BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.
    BioE-1115
Cat. No. Product Name / Synonyms Application Reactivity