2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W067056R
    Methyl (E)-cinnamate (Standard) 1754-62-7
    Methyl (E)-cinnamate (Standard) is the analytical standard of Methyl (E)-cinnamate. This product is intended for research and analytical applications. Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry.
    Methyl (E)-cinnamate (Standard)
  • HY-W086896R
    α-Demethylnaproxen (Standard) 23981-47-7
    α-Demethylnaproxen (Standard) is the analytical standard of α-Demethylnaproxen. This product is intended for research and analytical applications. α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity.
    α-Demethylnaproxen (Standard)
  • HY-W087988R
    3-Pentanol (Standard) 584-02-1
    3-Pentanol (Standard) is an analytical reference standard of 3-Pentanol. 3-Pentanol is an active organic compound produced by plants and is a component of insect-released pheromones. 3-Pentanol can trigger plant immunity against microbial pathogens and pests in crops by activating the SA and JA signaling pathways.
    3-Pentanol (Standard)
  • HY-W094747A
    Benzalazine 588-68-1
    Benzalazine is a 5-azo derivative of 5-Aminosalicylic Acid (HY-15027) that can be used for the research of ulcerative colitis and Crohn's disease of the large intestine. The benzalazine metabolite 5-ASA and the 5-ASA metabolite acetyl-5-aminosalicylic acid are excreted mainly with the faeces.
    Benzalazine
  • HY-W099331R
    Monoethylglycinexylidide (hydrochloride) (Standard) 7729-94-4
    Benfuracarb (Standard) is the analytical standard of Benfuracarb. This product is intended for research and analytical applications. Benfuracarb is a broad-spectrum carbamate insecticide with crop protection activity. Benfuracarb is used to control springtails, aphids, and other pests, typically on sugar beet crops. Benfuracarb exhibits toxicity to humans and aquatic organisms. Benfuracarb exposure to zebrafish embryos resulted in a reduction in the body length of zebrafish larvae. Superoxide dismutase (SOD) activity was significantly increased after Benfuracarb treatment. Benfuracarb also interfered with the transcriptional levels of marker genes associated with early embryonic development.
    Monoethylglycinexylidide (hydrochloride) (Standard)
  • HY-W714076R
    Ametoctradin (Standard) 865318-97-4
    Ametoctradin (Standard) is the analytical standard of Ametoctradin. This product is intended for research and analytical applications. Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews.
    Ametoctradin (Standard)
  • HY-W763569A
    Hydrolyzed Glutenin 8002-80-0
    Hydrolyzed Glutenin is a kind of wheat protein. Glutenin has a unique amino acid chain where glutamic acid, proline, and leucine constitute about 50% of the amino acids.
    Hydrolyzed Glutenin
  • HY-W782032A
    3D-Monophosphoryl Lipid A-5 free acid 1465797-24-3
    3D-Monophosphoryl Lipid A-5 (free acid) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines.
    3D-Monophosphoryl Lipid A-5 free acid
  • HY-114360AS1
    Taurohyodeoxycholic acid-d4 sodium
    Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium). Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
    Taurohyodeoxycholic acid-d4 sodium
  • HY-118861AS1
    Clomiphene-d5 citrate 1217200-17-3
    Clomiphene-d5 (citrate) is the deuterium labeled Enclomiphene citrate. Enclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property[1].
    Clomiphene-d5 citrate
  • HY-119695AS2
    Simvastatin acid-d3 ammonium
    Simvastatin acid-d3 (Tenivastatin-d3) ammonium is deuterium-labeled Simvastatin acid (ammonium) (HY-119695A).
    Simvastatin acid-d3 ammonium
  • HY-W012531S2
    2-Hydroxycinnamic acid-d4
    2-Hydroxycinnamic acid-d4 is deuterium labeled 2-Hydroxycinnamic acid. 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity.
    2-Hydroxycinnamic acid-d4
  • HY-103344
    ZJ43 723331-20-2
    ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models.
    ZJ43
  • HY-108659
    NF340 202982-98-7
    NF340 is a potent and selective P2Y11 receptor antagonist. NF340 inhibits the activity of P2Y11R by completely combining with ATP-binding amino acid residues. NF340 ameliorates inflammation in human fibroblast-like synoviocytes and can be used for rheumatoid arthritis research.
    NF340
  • HY-110216
    5J-4 827001-82-1
    5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation.
    5J-4
  • HY-119160
    TM5007 342595-05-5
    TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung.
    TM5007
  • HY-B0335S
    Tolfenamic Acid-D4 1246820-82-5
    Tolfenamic acid-d4 is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].
    Tolfenamic Acid-D4
  • HY-B0493S
    Niflumic Acid-d5 1794811-58-7
    Niflumic Acid-d5 is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].
    Niflumic Acid-d5
  • HY-B0674S
    Ebastine-d5 1216953-13-7
    Ebastine-d5 is the deuterium labeled Ebastine. Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1][2].
    Ebastine-d5
  • HY-B0683S
    Limaprost-d3 1263190-37-9
    Limaprost-d3 (17α,20-dimethyl-δ2-PGE1-d3) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research[1][2].
    Limaprost-d3
Cat. No. Product Name / Synonyms Application Reactivity