2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N15303
    Goyazensolide 60066-35-5 98%
    Goyazensolide is an inhibitor of NF-κB that can induce apoptosis in cancer cells and exhibits both anti-inflammatory and anticancer activities. Goyazensolide is a sesquiterpene lactone that can be found in the Argentine herb Centratherum punctatum.
    Goyazensolide
  • HY-N15307
    Trigraecum 38070-97-2 98%
    Trigraecum is a flavonoid compound found in Dracaena steudneri and Dalbergia cochinchinensis, exhibiting anti-inflammatory activity. It can inhibit the LPS (HY-D1056)-induced production of IL-1β, IL-2, GM-CSF, and TNF-α in human peripheral blood mononuclear cells. Trigraecum holds promise for research on inflammatory diseases.
    Trigraecum
  • HY-N15316
    cis-9,cis-12-Heptadecadienoic acid 29203-97-2 98%
    cis-9,cis-12-Heptadecadienoic acid is an antioxidant that can be isolated from the oil production fungus PJX-29.
    cis-9,cis-12-Heptadecadienoic acid
  • HY-N15321
    Norselic acid B 1190954-39-2 98%
    Norselic acid B is a natural compound that can be isolated from the sponge Crella sp. collected in Antarctica. T. Norselic acid B is active against the Leishmania parasite.
    Norselic acid B
  • HY-N15322
    Polyandric acid A 1282509-78-7 98%
    Polyandric acid A is a clerodane diterpenoid that can be isolated from the Australian medicinal plant D. polyandra. Polyandric acid A attenuates pro-inflammatory cytokine secretion.
    Polyandric acid A
  • HY-N15323
    Samioside 360768-68-9 98%
    Samioside is an effective acetylcholinesterase inhibitor that can be isolated from Phlomis nissolii and P. capitata. Samioside possesses free-radical scavenging and antimicrobial activities. Samioside can be used in research on its anti-Alzheimer’s potency.
    Samioside
  • HY-N15335
    Anti-inflammatory agent 98 1175517-20-0 98%
    Anti-inflammatory agent 98 (Compound 8) is a potent NO production inhibitor with an IC50 value of 14.79 μM. Anti-inflammatory agent 98 is a benzofuran with anti-inflammatory activities, which is found in the roots of Paeonia lactiflora Pall.
    Anti-inflammatory agent 98
  • HY-N15344
    Euryachin E 98%
    Euryachin E is an antimicrobial and antiviral agent found in Eurya chinensis. It exhibits a MIC of 6.25 μg/mL against B. cereus and 0.78 μg/mL against S. aureus. Its IC50 against COVID-19 is 6.41 μM. Euryachin E can be utilized for research in the fields of infection and inflammation.
    Euryachin E
  • HY-N15347
    Talaromyketide B 98%
    Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases.
    Talaromyketide B
  • HY-N15371
    Barbinine 123497-99-4 98%
    Barbinine is a diterpene alkaloid with antibacterial, antioxidant, anti-inflammatory and antitumor activities. Barbinine is a phytotoxin found in several Delphinium species.
    Barbinine
  • HY-N15378
    β-Carotene-15,15'-epoxide 132541-62-9 98%
    β-carotene-15,15ʹ-epoxide is a XIAP antagonist with apoptosis-inducing and antitumor activity, found in the leaves of Spondias mombin. In a DMBA (HY-W011845)-induced rat model of breast cancer, β-carotene-15,15ʹ-epoxide binds to the BIR3 domain of the anti-apoptotic protein XIAP, blocking its interaction with caspase-9 and thereby promoting tumor cell apoptosis. In addition, β-carotene-15,15ʹ-epoxide significantly downregulates the expression of BCL-2, COX-2, and TNF-α in tumor tissues, reduces MDA levels, increases catalase activity, and modulates serum levels of LDH, ALP, and ALT, demonstrating strong antioxidant, anti-inflammatory, and metabolic protective effects. β-carotene-15,15ʹ-epoxide may be used in research on inflammation-related conditions and cancers such as breast cancer.
    β-Carotene-15,15'-epoxide
  • HY-N15382
    Prebetanin 13798-16-8 98%
    Prebetanin (Betanin 6'-O-sulphate) is a pigment with antioxidant activities. Prebetanin can be isolated from beetroot.
    Prebetanin
  • HY-N15408
    Terminaline 15112-49-9 98%
    Terminaline is a compound that can be isolated from Sarcococca saligna. Terminaline has immunosuppressive activity and can inhibit the proliferation of T cells and the production of IL-2. In vivo, Terminaline can reduce CCl4-induced liver injury and has a good hepatoprotective effect.
    Terminaline
  • HY-N15415
    Zaluzanin C 16838-87-2 98%
    Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes.
    Zaluzanin C
  • HY-N15422
    Glucoputranjivin 18432-16-1 98%
    Glucoputranjivin (compound 1) is a reference compound that can be used for qualitative and quantitative determinations of active compounds in SO.
    Glucoputranjivin
  • HY-N15423
    Acrophylline 18904-40-0 98%
    Acrophylline is an antiallergic compound. Acrophylline inhibits mast cell degranulation. Acrophylline reduces the plasma leakage in mouse ear in a passive cutaneous anaphylactic (PCA) reaction. Acrophylline is an alkaloid can be isolated from acronychia haplophylla.
    Acrophylline
  • HY-N15440
    Mutatochrome 515-06-0 98%
    Mutatochrome (Citroxanthin) is a naturally occurring carotenoid pigment found in certain plants. Mutatochrome has antioxidant property to help protect cells from damage caused by free radicals. Mutatochrome can be used for anti-inflammatory and anticancer study.
    Mutatochrome
  • HY-N15444
    Bullatenone 493-71-0 98%
    Bullatenone is a volatile bioactive compound that can be found in Lophomyrtus bullata. It has insect - repellent, anti - ulcer, anti - UV, and antifungal activities. Bullatenone can inhibit the growth of fungi such as Candida albicans and Cladosporium resinae. Bullatenone can be used in the research of diseases such as inflammation and infections.
    Bullatenone
  • HY-N15473
    Isopaucifloral F 1001259-00-2 98%
    Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC50: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD50 in rats: > 5 mg/kg.
    Isopaucifloral F
  • HY-N1547R
    Prudomestin (Standard) 3443-28-5
    Prudomestin (Standard) is the analytical standard of Prudomestin. This product is intended for research and analytical applications. Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6?μM).
    Prudomestin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity