2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1431A
    Tabersonine hydrochloride 29479-00-3 98%
    Tabersonine hydrochloride is a selective, orally active NLRP3 inhibitor. Tabersonine hydrochloride directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and caspase-1 activation, and reducing the release of pro-inflammatory cytokines such as IL-1β. Tabersonine hydrochloride also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK signaling pathways. Tabersonine hydrochloride can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine hydrochloride is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer.
    Tabersonine hydrochloride
  • HY-N14323
    Madindoline A 184877-64-3 98%
    Madindoline A is an IL-6 inhibitor. Madindoline A inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with an IC50 of 8 μM. Madindoline A has no antimicrobial effect.
    Madindoline A
  • HY-N1433R
    Phytolaccagenin (Standard) 1802-12-6
    Phytolaccagenin (Standard) is the analytical standard of Phytolaccagenin. This product is intended for research and analytical applications. Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity
    Phytolaccagenin (Standard)
  • HY-N14423
    Concanamycin D 144450-34-0 98%
    Concanamycin D is a lysosomal acidification inhibitor with an IC50 value of 0.085 nM.
    Concanamycin D
  • HY-N14425
    Concanamycin E 144450-35-1 98%
    Concanamycin E is a lysosomal acidification inhibitor with an IC50 value of 0.038 nM.
    Concanamycin E
  • HY-N1445R
    Isoquercitrin (Standard) 482-35-9
    Isoquercetin (Standard) is the analytical standard of Isoquercetin. This product is intended for research and analytical applications. Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies.
    Isoquercitrin (Standard)
  • HY-N1451R
    Betulonic acid (Standard) 4481-62-3
    Betulonic acid (Standard) is the analytical standard of Betulonic acid. This product is intended for research and analytical applications. Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities.
    Betulonic acid (Standard)
  • HY-N14549
    Cycloepoxydon 193481-66-2 98%
    Cycloepoxydon inhibits the Phorbol 12-myristate 13-acetate (HY-18739) (PMA)-induced NF-KB and AP-1 mediated secreted alkaline phosphatase (SEAP) expression with IC50s of 1-2 μg/mL (4.2-8.4 μM) and 3-5 μg/mL (12.6-21 μM), respectively.
    Cycloepoxydon
  • HY-N14670
    Pentenocin A 249283-62-3 98%
    Pentenocin A weakly inhibits the activity of IL-1 and β-transferase (ICE).
    Pentenocin A
  • HY-N14672
    Pentenocin B 249283-63-4 98%
    Pentenocin B weakly inhibits the activity of IL-1 and β-transferase (ICE).
    Pentenocin B
  • HY-N14688
    Phenylpyropene B 556013-83-3 98%
    Phenylpyropene B can inhibit ACAT activity with IC50 of 12.8 μM.
    Phenylpyropene B
  • HY-N1469R
    Kaurenoic acid (Standard) 6730-83-2
    Kaurenoic acid (Standard) is the analytical standard of Kaurenoic acid. This product is intended for research and analytical applications. Kaurenoic acid is a diterpene from Sphagneticola trilobata, inhibits Inflammatory Pain by the inhibition of cytokine production and activation of the NO–cyclic GMP–PKG–ATP-sensitive potassium channel signaling pathway.
    Kaurenoic acid (Standard)
  • HY-N14737
    Dunaimycin A1 140221-72-3 98%
    Dunaimycin A1 is a 24-membered macrolide compound with immunosuppressive activity and antifungal activity against Aspergillus niger. Dunaimycin A1 is promising for research of autoimmune diseases.
    Dunaimycin A1
  • HY-N14780
    Pochonin D 544712-82-5 98%
    Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers.
    Pochonin D
  • HY-N1482R
    Methyl palmitate (Standard) 112-39-0
    Methyl palmitate (Standard) is the analytical standard of Methyl palmitate. This product is intended for research and analytical applications. Methyl palmitate, an acaricidal compound occurring in Lantana camara, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects.
    Methyl palmitate (Standard)
  • HY-N14837
    Lymphostin 191474-39-2 98%
    Lymphostin is an immunosuppressant. Lymphostin has inhibitory effects on lymphocyte kinase (IC50 is 0.05 μM), and it also inhibits mixed lymphocyte response (IC50 is 0.009 μM). Lymphostin has no effect on the Gram-positive bacteria and negative bacteria.
    Lymphostin
  • HY-N14927
    Phepropeptin A 396729-23-0 98%
    Phepropeptin A, a microbial secondary metabolite, is a proteasome inhibitor with an IC50 of 21 μg/mL.
    Phepropeptin A
  • HY-N14928
    Phepropeptin B 396729-24-1 98%
    Phepropeptin B, a microbial secondary metabolite, is a proteasome inhibitor with an IC50 of 11 μg/mL.
    Phepropeptin B
  • HY-N14929
    Phepropeptin C 396729-25-2 98%
    Phepropeptin C, a microbial secondary metabolite, is a proteasome inhibitor with an IC50 of 12.5 μg/mL.
    Phepropeptin C
  • HY-N14940
    Phepropeptin D 396729-26-3 98%
    Phepropeptin D, a microbial secondary metabolite, is a proteasome inhibitor with an IC50 of 7.8 μg/mL.
    Phepropeptin D
Cat. No. Product Name / Synonyms Application Reactivity