2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-160228A
    ORN 02 sodium
    ORN 02 (sodium) is a synthetic single-stranded U-rich RNA and contains 6 repeats of UUAU sequence motif. The AU-rich oligoribonucleotides (ORNs) are able to stimulate TLR8.
    ORN 02 sodium
  • HY-161534A
    Sulfadiazine-OVA
    Sulfadiazine-OVA is a conjugate of Sulfadiazinen (HY-B0273) and Ovalbumin (OVA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
    Sulfadiazine-OVA
  • HY-161554A
    Clenbuterol-OVA
    Clenbuterol-OVA is a conjugate of Clenbuterol (HY-101406) and Ovalbumin (OVA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
    Clenbuterol-OVA
  • HY-161557A
    Ractopamine-OVA
    Ractopamine-OVA is a conjugate of Ractopamine (HY-113781) and Ovalbumin (OVA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
    Ractopamine-OVA
  • HY-162495A
    (S)-IDOR-1117-2520
    (S)-IDOR-1117-2520 is the S-isomer of IDOR-1117-2520 (HY-162495). IDOR-1117-2520 is a potent and selective CCR6 antagonist. IDOR-1117-2520 can be used in the research of autoimmune diseases.
    (S)-IDOR-1117-2520
  • HY-162655A
    SLF80821178 hydrochloride 2764877-62-3 98%
    SLF80821178 hydrochloride is an orally active inhibitor for sphingosine-1-phosphate transporter (Spns2), that inhibits the sphingosine-1-phosphate (S1P) release in HeLa with an IC50 of 51 nM. SLF80821178 hydrochloride reduces the circulating lymphocyte without affecting plasma S1P levels in mice.
    SLF80821178 hydrochloride
  • HY-163312S
    Tyk2-IN-18-d5 3018160-63-6 98%
    Tyk2-IN-18-d5 (Compound 13) is the deuterated TYK2 inhibitor, targeting to JH2 domain. Tyk2-IN-18-d5 can be used for the research of inflammatory and autoimmune diseases.
    Tyk2-IN-18-d5
  • HY-163313S
    Tyk2-IN-19-d6 3018160-65-8 98%
    Tyk2-IN-19-d6 (compound 15) is the deuterium labeled Tyk2-IN-19 (HY-163313).
    Tyk2-IN-19-d6
  • HY-163581A
    HBV/HDV-IN-4 hydrochloride 3034059-40-7 98%
    HBV/HDV-IN-4 hydrochloride (Compd 4) is a dual HBV and HDV inhibitor, with an EC50 of <50 nM against HBV.
    HBV/HDV-IN-4 hydrochloride
  • HY-164216A
    (trans)-STAT6 modulator-5
    (trans)-STAT6 modulator-5 (Compound 95) is a STAT6 protein modulator that inhibits the STAT6 signaling pathway. (trans)-STAT6 modulator-5 is promising for research of inflammatory diseases and allergic reactions.
    (trans)-STAT6 modulator-5
  • HY-16561S1
    Resveratrol-13C6 98%
    Resveratrol-13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol-13C6
  • HY-167084A
    ASP9133 1047677-07-5
    ASP9133 is a long-acting muscarinic antagonist. ASP9133 inhibits bronchoconstriction. ASP9133 can be used for research of Chronic obstructive pulmonary disease (COPD)[1]/.
    ASP9133
  • HY-167845S
    Exemestane-19-d3
    Exemestane-19-d3 is the deuterium labeled LD03-DEX (HY-167845). LD03-DEX is a precursor compound of dexamethasone (HY-14648) with immunosuppressive activity.
    Exemestane-19-d3
  • HY-167855S
    1’-Epi Gemcitabine hydrochloride-13C,15N2
    1’-Epi Gemcitabine hydrochloride-13C,15N2 is the 13C- and 15N-labeled MRS4833 (HY-167855). MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
    1’-Epi Gemcitabine hydrochloride-13C,15N2
  • HY-167926S
    Mycophenolic Acid-d3 beta-D-Glucuronide
    Mycophenolic Acid-d3 beta-D-Glucuronide is the deuterium labeled 3-Bromo-4,5-dihydroxybenzoic acid methyl ester (HY-167926). 3-Bromo-4,5-dihydroxybenzoic acid methyl ester is a marine-derived natural product known for its biological activity, specifically showcasing antioxidant properties and potential therapeutic applications against oxidative stress-related diseases.
    Mycophenolic Acid-d3 beta-D-Glucuronide
  • HY-16908AR
    Lefamulin acetate (Standard) 1350636-82-6
    Lefamulin (acetate) (Standard) is the analytical standard of Lefamulin (acetate). This product is intended for research and analytical applications. Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia[1].
    Lefamulin acetate (Standard)
  • HY-169115A
    (Rac)-PD0299685 313651-02-4 98%
    (Rac)-PD0299685 is a Ca(2+) channel α2δ ligand that was investigated for relieving interstitial cystitis pain in a randomized, double-blind, placebo-controlled phase IIa study. (Rac)-PD0299685 demonstrated a clinically significant reduction in daily worst pain severity scores at the 60 mg dose compared to placebo. (Rac)-PD0299685 is also a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.
    (Rac)-PD0299685
  • HY-169225A
    PDIC-NN dimethanesulfonate 3040919-39-6
    PDIC-NN dimethanesulfonate (PDIC-NS) is a STING activator with anticancer activity. PDIC-NN dimethanesulfonate promotes the content and biostability of endogenous cyclic dinucleotides (CDNs). PDIC-NN dimethanesulfonate triggers ROS burst and causes serious damage to mitochondria. PDIC-NN dimethanesulfonate induces cell apoptosis and inhibits DNA replication. PDIC-NN dimethanesulfonate activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response.
    PDIC-NN dimethanesulfonate
  • HY-169984S
    Tyk2-IN-22-d3 1771691-32-7 98%
    Tyk2-IN-22-d3 (Compound 1) is the deuterated analog of Tyk2-IN-22 (HY-168339). Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation.
    Tyk2-IN-22-d3
  • HY-169986S
    TyK2-IN-21-d3 2583719-08-6 98%
    TyK2-IN-21-d3 (Compound 3c) is the orally active prodrug of the tyrosine kinase 2. TyK2-IN-21-d3 exhibits good chemical stability in aqueous system under different pHs. TyK2-IN-21-d3 alleviates the effect of gastric acid changes on drug absorption and improve the drug bioavailability in rat model.
    TyK2-IN-21-d3
Cat. No. Product Name / Synonyms Application Reactivity