2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-159920
    PSB-22269 98%
    PSB-22269 is a GPR17 antagonist with a Ki value of 8.91 nM. PSB-22269 further demonstrated significant inhibitory effects in cAMP and G protein activation assays. Molecular docking studies revealed that the binding site of PSB-22269 contains positively charged arginine residues and a hydrophobic pocket. PSB-22269 provides a strategy to promote remyelination and holds promise for research in the field of multiple sclerosis.
    PSB-22269
  • HY-160168
    BTK-IN-31 2662512-02-7 98%
    BTK-IN-31 (Compound 2) is a selective, non-covalently reversible, and blood-brain barrier (BBB) permeable Btk inhibitor. BTK-IN-31 has research potential in immune disorders, cancer, cardiovascular disease, viral infections, inflammation, metabolic/endocrine dysfunction, and neurological disorders.
    BTK-IN-31
  • HY-160265
    URAT1 inhibitor 9 2251727-90-7 98%
    URAT1 inhibitor 9 (Compound 24) is an URAT1 inhibitor that can be used in the study of gout or hyperuricemia.
    URAT1 inhibitor 9
  • HY-160420
    Cinoxolone 31581-02-9 98%
    Cinoxolone, a derivative of glycyrrhetinic acid, is an antiulcer agent.
    Cinoxolone
  • HY-160446
    BET-IN-24 2407658-21-1 98%
    Bet-in-24 (example 2) is a bromodomain and extra-terminal (BET) inhibitor. BET-IN-24 can be used in the study of virology, heart failure, inflammation, central nervous system (CNS) diseases and many cancers
    BET-IN-24
  • HY-160554
    C12-113 1220890-27-6 98%
    C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice.
    C12-113
  • HY-160569
    C14-SPM 2241864-59-3 98%
    C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA.
    C14-SPM
  • HY-160615
    TP receptor antagonist-1 1448452-21-8 98%
    TP receptor antagonist-1 (compound 7m) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 9.46 μM for TPa and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease.
    TP receptor antagonist-1
  • HY-160647
    CCR8 antagonist 3 912463-57-1 98%
    CCR8 antagonist 3 (compound 2) is a CCR8 antagonist with an IC50 value of 0.062 µM. CCR8 antagonist 3 shows human microsomal stability.
    CCR8 antagonist 3
  • HY-160658
    AZ760 912461-36-0 98%
    AZ760 is a CCR8 antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition.
    AZ760
  • HY-160822
    AGG-523 920289-29-8 98%
    AGG-523 (PF-5212371) is a reversible, non-hydroxamate, zinc-binding selective aggrecanase 1 (ADAMTS4) and aggrecanase 2 (ADAMTS5) inhibitor. AGG-523 can be used for the study of osteoarthritis (OA).
    AGG-523
  • HY-160896
    Autophagy-IN-5 1262888-20-9 98%
    Autophagy-IN-5 (Compound A9) is an inhibitor for autophagy with an EC50 of 0.736 μM.
    Autophagy-IN-5
  • HY-160901
    CP-289,503 1349637-14-4 98%
    CP-289,503 is an inhibitor of the complement C5a receptor with an IC50 of 1 μM. C5a acts as an activator of leukocytes and phagocytes during complement system activation. The C5a receptor can bind to C5a, which can stimulate the upregulation of cell surface integrins and degranulation of inflammatory cells, leading to endothelial cell damage. C5a receptor inhibitors can block C5a signaling and inhibit a variety of inflammatory diseases.
    CP-289,503
  • HY-160930
    TOP1288 1630202-02-6 98%
    TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC50 of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts.
    TOP1288
  • HY-161043
    ECDD-S16 98%
    ECDD-S16 is a potent inhibitor of pyroptosis. ECDD-S16 inhibits surface and endosomal TLR ligands activated pyroptosis in Raw264.7 cells.
    ECDD-S16
  • HY-16126R
    Carboxyamidotriazole (Standard) 99519-84-3
    Carboxyamidotriazole (Standard) is the analytical standard of Carboxyamidotriazole. This product is intended for research and analytical applications. Carboxyamidotriazole (L-651582) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole shows anti-tumor, anti-inflammatory and antiangiogenic effects.
    Carboxyamidotriazole (Standard)
  • HY-161533
    Digoxin/BSA 98%
    Digoxin/BSA is an antigen-adjuvant conjugate of Digoxin (HY-B1049) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
    Digoxin/BSA
  • HY-161551
    25-OH Vitamin D3/KLH 98%
    25-OH Vitamin D3/KLH is an antigen-adjuvant conjugate of 25-OH Vitamin D3 (HY-158285) and Keyhole Limpet Hemocyanin (KLH). By conjugating the antigen with the protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
    25-OH Vitamin D3/KLH
  • HY-161565
    Gastrin(1-17)/BSA 98%
    Gastrin(1-17)/BSA is an antigen-adjuvant conjugate formed by the coupling of Gastrin(1-17) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or destroy major epitopes, and it can enhance cross-presentation and the production of antigen-specific T cells.
    Gastrin(1-17)/BSA
  • HY-161907
    h15-LOX-2 inhibitor 2 98%
    h15-LOX-2 inhibitor 2 (Compound 10) is an inhibitor of h15-LOX, with IC50 and Ki values of 26.9 μM and 16.4 μM, respectively.
    h15-LOX-2 inhibitor 2
Cat. No. Product Name / Synonyms Application Reactivity