2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-156415
    NLRP3 agonist 2 98%
    NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates Caspase-1 in THP1 cells.
    NLRP3 agonist 2
  • HY-156424
    NOX2-IN-1 2648709-25-3 98%
    NOX2-IN-1 (compound 10) is an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2). NOX2-IN-1 targets the p47phox p22phox protein protein interaction with favorable binding affinities and cellular activities.
    NOX2-IN-1
  • HY-156431
    Anti-inflammatory agent 61 98%
    Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. Anti-inflammatory agent 61 reduces TNF-α expression in LPS-induced inflammation in RAW 264.7 cells. Anti-inflammatory agent 61 alleviates APAP-induced inflammation in HepG2 cells.
    Anti-inflammatory agent 61
  • HY-156436
    Anti-inflammatory agent 62 98%
    Anti-inflammatory agent 62 is an anti-inflammatory agent. Anti-inflammatory agent 62 alleviate Acetaminophen-induced hepatotoxicity in HepG2 by the regulation of inflammatory and oxidative stress pathways.
    Anti-inflammatory agent 62
  • HY-156468
    Antioxidant agent-17 98%
    Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC50 of 9.06 nM.
    Antioxidant agent-17
  • HY-15651S
    Alvelestat-13C,d3 98%
    Alvelestat-13C,d3 (AZD9668-13C,d3) is 13C-labeled Alvelestat (HY-15651).
    Alvelestat-13C,d3
  • HY-156520
    Immunosuppressant-1 1224571-03-2 98%
    Immunosuppressant-1 (Compound 31) inhibits anti-CD3/anti-CD28 co-stimulated T-cell proliferation. Immunosuppressant-1 has immunosuppressive activity, and induces apoptosis by activating caspase-3 and PARP in activated lymph node cells.
    Immunosuppressant-1
  • HY-156711
    Ternatumoside II 1473419-87-2 98%
    Ternatumoside II is a flavonoid glycoside that can be isolated from R. crenulata. Ternatumoside II can stimulate IFN-γ expression. Ternatumoside II has radical-scavenging activities (IC50s: 260.5 μM and 320.2 μM for DPPH and ABTS).
    Ternatumoside II
  • HY-156722
    ER-34122 179325-62-3 98%
    ER-34122 is a dual 5-lipoxygenase/cyclooxygenase inhibitor with oral activity. ER-34122 has anti-inflammatory activity.
    ER-34122
  • HY-157040
    MAGL-IN-9 98%
    MAGL-IN-9 (compound 16) is a selective and reversible MAGL inhibitor with IC50 2.7 nM.
    MAGL-IN-9
  • HY-157042
    MAGL-IN-11 3017151-84-4 98%
    MAGL-IN-11 (compound 29) is a selective and reversible MAGL inhibitor. MAGL-IN-11 has the potential to study inflammation, cancer and antioxidants.
    MAGL-IN-11
  • HY-157171
    Ac-YR-NH2 126530-17-4 98%
    Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response.
    Ac-YR-NH2
  • HY-157174
    Mannosamine–desthiobiotin adduct 98%
    Mannosamine-desthiobiotin adduct (compound MDTBA) is a carrier immunogenicity-reducing hapten that reduces the immunogenicity of protein carriers upon conjugation to available free amines on the carrier protein surface. Conjugation of Mannosamine-desthiobiotin adduct to hsIgG significantly (>1-fold) reduced the immunogenicity of hsIgG. Mannosamine-desthiobiotin adduct can be used in antigen design research.
    Mannosamine–desthiobiotin adduct
  • HY-157193
    Diacylglyceride 73566-74-2 98%
    Diacylglyceride, a natural scaffolding lipid, is a hapten that binds to CD1b. Diacylglyceride can be combined with carrier proteins and used in the design of antigens.
    Diacylglyceride
  • HY-157201
    ZEo 98%
    Zeo is a hapten of zearalenone with longer linkers and with alternative tethering sites have been designed for immunizing and assay conjugate preparation.
    ZEo
  • HY-157218
    PPm 2101951-47-5 98%
    PPm, a derivative of penthiopyrad and hapten, is a representative member of the succinate dehydrogenase inhibitors group of fungicides.
    PPm
  • HY-157235
    AC Antibody affinity resin 98%
    AC Antibody affinity resin is AC commonly used packing. AC Antibody affinity resin has highly cross-linked agarose matrix with 85 μm of average particle size. AC Antibody affinity resin has alkali-resistant protein A derivative (E. coli) ligand. AC Antibody affinity resin can be used for antibody affinity chromatography.
    AC Antibody affinity resin
  • HY-157280
    AdCaPy 307320-40-7 98%
    AdCaPy is an MHC II antigen loading catalyst that accelerates the loading of peptide antigens by MHC II. AdCaPy is a useful molecular tool for enhancing immune responses.
    AdCaPy
  • HY-157282
    Photolumazine I 29161-67-9 98%
    Photolumazine I(PLI) is a vitamin B-based hapten.Photolumazine Icanactivates Mucosal-associated Invariant T clones.
    Photolumazine I
  • HY-157333
    CYP51-IN-15 3034186-60-9 98%
    CYP51-IN-15 (9B) is a BBB penetrated Naegleria fowleri-specific CYP51 inhibitor, with an EC50 of 1.5 μM.
    CYP51-IN-15
Cat. No. Product Name / Synonyms Application Reactivity