2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15123R
    (S)-Flurbiprofen (Standard) 51543-39-6
    (S)-Flurbiprofen (Standard) is the analytical standard of (S)-Flurbiprofen. This product is intended for research and analytical applications. (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively.
    (S)-Flurbiprofen (Standard)
  • HY-151241
    Sinomenine N-oxide 1000026-77-6 ≥99.0%
    Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM.
    Sinomenine N-oxide
  • HY-151792
    Pomalidomid-C6-PEG3-butyl-N3 2300178-66-7 98%
    Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Pomalidomid-C6-PEG3-butyl-N3
  • HY-15204S
    Tonabersat-d6 1329837-33-3 98%
    Tonabersat-d6 (SB-220453-d6) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system.
    Tonabersat-d6
  • HY-15230R
    Geldanamycin (Standard) 30562-34-6
    Geldanamycin (Standard) is the analytical standard of Geldanamycin. This product is intended for research and analytical applications. Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.
    Geldanamycin (Standard)
  • HY-15234R
    Fluticasone furoate (Standard) 397864-44-7
    Fluticasone furoate (Standard) is the analytical standard of Fluticasone furoate. This product is intended for research and analytical applications. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment.
    Fluticasone furoate (Standard)
  • HY-15307S
    Belumosudil-d7 98%
    Belumosudil-d7 (KD025-d7) is deuterium labeled Belumosudil. Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties.
    Belumosudil-d7
  • HY-15311R
    Avermectin B1 (Standard) 71751-41-2
    Avermectin B1 (Standard) is the analytical standard of Avermectin B1. This product is intended for research and analytical applications. Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy.
    Avermectin B1 (Standard)
  • HY-153133
    CFTR corrector 11 688050-45-5 99.80%
    CFTR corrector 11 (compound 133) is a CFTR corrector. CFTR corrector 11 can be used for the study of cystic fibrosis.
    CFTR corrector 11
  • HY-15315R
    Baricitinib (Standard) 1187594-09-7
    Baricitinib (Standard) is the analytical standard of Baricitinib. This product is intended for research and analytical applications. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
    Baricitinib (Standard)
  • HY-15405R
    Teriflunomide (Standard) 163451-81-8
    Teriflunomide (Standard) is the analytical standard of Teriflunomide. This product is intended for research and analytical applications. Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation.
    Teriflunomide (Standard)
  • HY-15455R
    Roflumilast (Standard) 162401-32-3
    Roflumilast (Standard) is the analytical standard of Roflumilast. This product is intended for research and analytical applications. Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
    Roflumilast (Standard)
  • HY-154829
    AC-099 849459-88-7 98%
    AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats.
    AC-099
  • HY-15495B
    (3S)-Tanzisertib hydrochloride 2517855-91-1
    (3S)-Tanzisertib (hydrochloride) ((3S)-CC-930 (hydrochloride)) is an orally active JNK inhibitor (IC50 values for JNK1, JNK2, and JNK3 are 61, 7, and 6 nM, respectively). (3S)-Tanzisertib (hydrochloride) selectively inhibits ERK1, p38α, and EGFR (IC50 = 0.48, 3.4, and 0.38 μM, respectively). (3S)-Tanzisertib (hydrochloride) inhibits LPS-induced TNFα production in an acute rat PK-PD model. (3S)-Tanzisertib (hydrochloride) can be used in idiopathic pulmonary fibrosis (IPF) research.
    (3S)-Tanzisertib hydrochloride
  • HY-155169
    hLTA4H/hLTA4S-IN-1 128253-12-3 98%
    hLTA4H/hLTA4S-IN-1 is a possible dual inhibitor that has the activity of inhibiting both human leukotriene hydrolase (hLTA4H) and human leukotriene C4 synthase (hLTC4S). hLTA4H/hLTA4S-IN-1 was identified by computer-assisted methods and is able to effectively interfere with the leukotriene biosynthesis pathway in cells. hLTA4H/hLTA4S-IN-1 can be used to study inflammatory responses.
    hLTA4H/hLTA4S-IN-1
  • HY-155364
    Antimicrobial agent-26 3026743-44-9 98%
    Antimicrobial agent-26 is a potent antimicrobial agent and can mitigate antibiotic resistancein vitro.
    Antimicrobial agent-26
  • HY-155407
    ALR-6 6621-92-7 98%
    ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX.
    ALR-6
  • HY-155408
    ALR-27 903639-13-4 98%
    ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes.
    ALR-27
  • HY-155495
    (±)-Bupropion-(CH2)3-OH hydrochloride 80762-38-5 98%
    (±)-Bupropion-(CH2)3-OH hydrochloride (compound 3) is a hapten useful in the radioimmunoassay of Bupropion (HY-B0403).
    (±)-Bupropion-(CH2)3-OH hydrochloride
  • HY-156199
    o-Cresol sulfate 3233-56-5 98%
    o-Cresol sulfate is a biomarker related to CAR T cell-independent and dependent metabolic and inflammatory. o-Cresol sulfate can be used to predict patient response.
    o-Cresol sulfate
Cat. No. Product Name / Synonyms Application Reactivity