2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13718A
    Oglufanide disodium 237068-57-4 98%
    Oglufanide (H-Glu-Trp-OH) disodium is a dipeptide immunomodulator isolated from calf thymus. Oglufanide disodium inhibits vascular endothelial growth factor (VEGF). Oglufanide disodium can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide disodium shows antitumor and anti-angiogenesis activities.
    Oglufanide disodium
  • HY-137197
    6β-Hydroxy dexamethasone 55879-47-5 98%
    6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone (HY-14648).
    6β-Hydroxy dexamethasone
  • HY-137225
    HTS07944 706758-28-3 98%
    HTS07944 (HTS07944SC, C3) is a potent modulator of laminin receptor (37 LR). HTS07944 (HTS07944SC, C3) possesses anti-cancer activity in PC-3 cells and activates Caspase 3/7.
    HTS07944
  • HY-137418
    2-MeS-ATP 43170-89-4 98%
    2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases.
    2-MeS-ATP
  • HY-137583
    Peltatoside 23284-18-6 98%
    Peltatoside is a flavone which can be extracted from Annona crassilfora Mart, with an anti-inflammatory activity and can be used for relative research.
    Peltatoside
  • HY-137613
    Sp-TTPαS 83199-32-0 98%
    Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) catalysis inhibitor. Sp-TTPαS competitively inhibits TTP hydrolysis with a Ki value of 46 µM.
    Sp-TTPαS
  • HY-137909
    Formoterol O-β-D-glucuronide 615551-59-2 98%
    Formoterol O-β-D-glucuronide is a metabolite of Formoterol (HY-B0010). Formoterol is a potent, selective and long-acting β2-adrenoceptor agonist.
    Formoterol O-β-D-glucuronide
  • HY-137992
    Aucuparin 3687-28-3 98%
    Aucuparin, a natural product found in Sorbus aucuparia, inhibits pulmonary fibrosis in a bleomycin (HY-108345)-induced lung fibrosis mouse model. Aucuparin has anti-inflammatory activity and can inhibit the activation of inflammatory factors by TGF-β.
    Aucuparin
  • HY-138007
    SR-1903 1414248-06-8 98%
    SR-1903 is an inverse agonist of RORγ and PPARγ (IC50 of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a LXR agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models.
    SR-1903
  • HY-138063
    Siegeskaurolic acid 52645-97-3 98%
    Siegeskaurolic acid is an orally active anti-inflammatory agent. Siegeskaurolic acid inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and the activationon of nuclear factor-kappaB .
    Siegeskaurolic acid
  • HY-138110
    Toladryl 19804-27-4
    Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases.
    Toladryl
  • HY-138121
    PSB-KD107 955121-65-0 98%
    PSB-KD107 is an agonist of the cannabinoid activated orphan G-protein-coupled receptor GPR18, and PSB-KD107 has anti-inflammatory activity. PSB-KD107 can be used in the study of Duchenne muscular dystrophy.
    PSB-KD107
  • HY-138128
    Acetaminophen mercapturate 52372-86-8 98%
    Acetaminophen mercapturate is a metabolite of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor.
    Acetaminophen mercapturate
  • HY-138290
    Diclofenac acyl-β-D-glucuronide allyl ester 698358-10-0 98%
    Diclofenac acyl-β-D-glucuronide allyl ester is an intermediate in the synthesis of the COX inhibitor metabolite Diclofenac acyl glucuronide (HY-126848).
    Diclofenac acyl-β-D-glucuronide allyl ester
  • HY-138291
    Ethoxyquin dimer 74681-77-9 98.70%
    Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10 mg/kg shows hepatotoxicity in mice.
    Ethoxyquin dimer
  • HY-138570
    HLE-IN-1 13947-21-2 98%
    HLE-IN-1 (Compound 4) is a human leukocyte elastase HLE inhibitor (Ki=1.8 nM). HLE-IN-1 is used in emphysema and inflammamry pulmonary research.
    HLE-IN-1
  • HY-138812
    Antileishmanial agent-28 1135272-09-1 98%
    Antileishmanial agent-28 (Compd 12) is an antileishmanial agent, with EC50 values of 1.5 μM (L.donovani), 13 μM (L.amazonensis) and 18 μM (J774A.1), respectively.
    Antileishmanial agent-28
  • HY-138985
    CAY10568 22913-17-3 98%
    CAY10568 is a compound based on QX-314 (HY-101350). CAY10568 is physically smaller and less hydrophobic than the QX-314. CAY10568 can be used in studies of inflammation and pain perception.
    CAY10568
  • HY-139095
    Cipamfylline 132210-43-6 98%
    Cipamfylline is a PDE4 inhibitor that can cause PDE4A4 to accumulate in specific areas of the cell through interaction with the ubiquitin scaffolding protein p62. Cipamfylline can be used in the research of atopic dermatitis.
    Cipamfylline
  • HY-139129
    N-(3-Pyridyl)indomethacinamide 261766-29-4 98%
    N-(3-Pyridyl)indomethacinamide is a derivative of Indomethacin (HY-14397). N-(3-Pyridyl)indomethacinamide is a COX2 inhibitor.
    N-(3-Pyridyl)indomethacinamide
Cat. No. Product Name / Synonyms Application Reactivity