2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130429
    14,15-Leukotriene C4 75290-60-7 98%
    14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases.
    14,15-Leukotriene C4
  • HY-130757
    Remisporine B 571194-06-4 98%
    Remisporine B is a polyketide, that can be isolated from Penicillium sp. ZJ-SY2. Remisporine B exhibits immunosuppressive efficacy, that inhibits concanavalin A (HY-P2149)-induced T-cell proliferation and LPS (HY-D1056)- induced B-cell proliferations of mouse splenic lymphocytes with IC50 of 30.1 µg/mL and 32.4 µg/mL.
    Remisporine B
  • HY-130787
    Apterin 53947-89-0 98%
    Apterin is a natural compound with anti-inflammatory activity. Apterin shows significantly inhibitory activity on NO production in RAW264.7 cells with an IC50 value of 41.8 μM.
    Apterin
  • HY-131396
    α-Hydroxy Montelukast 2045402-27-3 98%
    α-Hydroxy Montelukast (M7) is a metabolite of Montelukast (HY-13315A).
    α-Hydroxy Montelukast
  • HY-131461
    6-TET Dipivaloate 314734-87-7 98%
    6-TET Dipivaloate is a nucleic acid sequencing probe.
    6-TET Dipivaloate
  • HY-131663
    L-Lysinamide 32388-19-5 98%
    L-Lysinamide is an amide form of L-Lysine (HY-N0469). L-Lysine is an essential amino acid for humans with orally activity.
    L-Lysinamide
  • HY-131728
    GPR35 agonist 3 123021-85-2 98.32%
    GPR35 agonist 3 is a synthetic GPR35 agonist with an EC50value of 1.4 μM. GPR35 agonist 3 can be used for the research of various diseases, such as gastric cancer, type 2 diabetes, cardiovascular diseases, immune system and peripheral nervous system.
    GPR35 agonist 3
  • HY-13205R
    Belnacasan (Standard) 273404-37-8
    Belnacasan (Standard) is the analytical standard of Belnacasan. This product is intended for research and analytical applications. Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM.
    Belnacasan (Standard)
  • HY-132130
    BRD4 Inhibitor-13 218934-50-0 98%
    BRD4 Inhibitor-13 (Compound 2) is a BRD4 ligand, and can be used for research of cancer, inflammation.
    BRD4 Inhibitor-13
  • HY-132132
    Neutrophil elastase inhibitor 3 1234707-32-4 98%
    Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release.
    Neutrophil elastase inhibitor 3
  • HY-13213A
    AM211 sodium 1263077-74-2 98%
    AM211 sodium is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
    AM211 sodium
  • HY-13219R
    Tepoxalin (Standard) 103475-41-8
    Tepoxalin (Standard) is the analytical standard of Tepoxalin. This product is intended for research and analytical applications. Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile.
    Tepoxalin (Standard)
  • HY-132223
    LH1306 2182653-84-3 98%
    LH1306 is a C2-symmetric inhibitor of PD-1/PD-L1 protein-protein interaction (PPI), with an IC50 value of 25 nM. LH1306 can be used in anti-tumor research.
    LH1306
  • HY-132243
    NFAT Inhibitor-3 841210-82-0 98%
    NFAT Inhibitor-3 (Compound 10) is a factor nuclear factor of activated T cells (NFAT) inhibitor. NFAT Inhibitor-3 inhibits IL-2 production. NFAT Inhibitor-3 binds in a sequence-selective manner directly to DNA. NFAT Inhibitor-3 can be used for the research of transcription factor dysregulation.
    NFAT Inhibitor-3
  • HY-132289
    Lipid M 2089251-57-8 98%
    Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability.
    Lipid M
  • HY-13262R
    Lumacaftor (Standard) 936727-05-8
    Lumacaftor (Standard) is the analytical standard of Lumacaftor. This product is intended for research and analytical applications. Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
    Lumacaftor (Standard)
  • HY-13269R
    BMS-707035 (Standard) 729607-74-3
    BMS-707035 (Standard) is the analytical standard of BMS-707035. This product is intended for research and analytical applications. BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1).
    BMS-707035 (Standard)
  • HY-13295R
    Vinpocetine (Standard) 42971-09-5
    Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.
    Vinpocetine (Standard)
  • HY-133003
    L662,025 122328-38-5 98%
    L662,025 is a specific, photolabile and irreversible Platelet-activating factor (PAF-receptor) antagonist, with IC50 values of 5.6 μM (platelet aggregation) and 1 μM (receptor binding), respectively.
    L662,025
  • HY-133215
    Zileuton sulfoxide 1147524-83-1 98%
    Zileuton sulfoxide is a sulfoxide derivative of Zileuton (HY-14164), a potent and selective inhibitor of lipoxygenase 5-LOX with anti-asthmatic properties.
    Zileuton sulfoxide
Cat. No. Product Name / Synonyms Application Reactivity