2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-122175
    ZK-158252 162362-36-9 98%
    ZK-158252 is a leukotriene B4 type-2 receptor (BLT2) antagonist.
    ZK-158252
  • HY-122270
    Kahweol stearate 108214-31-9 98%
    Kahweol stearate is a diterpenoid ester found in coffee that exhibits anti-inflammatory, anticancer, and antiangiogenic activities.
    Kahweol stearate
  • HY-122536
    Ricinelaidic acid 540-12-5 98%
    Ricinelaidic acid, a 12-hydroxy fatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the Ki of 2 μM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50=10 and 7 μM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats.
    Ricinelaidic acid
  • HY-122655
    HMCEF 2002363-68-8 98%
    HMCEF is an orally active P-selectin inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice.
    HMCEF
  • HY-122848
    DDR1/2 inhibitor-3 2241813-33-0 98%
    DDR1/2 inhibitor-3 (5n) is a DDR1/2 inhibitor, with IC50 values​of 9.4 and 20.4 nM, respectively. DDR1/2 inhibitor-3 can be used in anti-inflammatory research.
    DDR1/2 inhibitor-3
  • HY-12288R
    Ozanimod (Standard) 1306760-87-1
    Ozanimod (Standard) is the analytical standard of Ozanimod. This product is intended for research and analytical applications. Ozanimod (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS).
    Ozanimod (Standard)
  • HY-12290R
    Arg-Gly-Asp-Ser (Standard) 91037-65-9
    Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
    Arg-Gly-Asp-Ser (Standard)
  • HY-122989
    Aristolactam BIII 53948-10-0 98%
    Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models.
    Aristolactam BIII
  • HY-123038
    CVT-5440 531506-64-6 98%
    CVT-5440 is a xanthine based, selective, high affinity A2B adenosine receptors (AdoR) antagonist with a Ki of 50 nM (selectivity A1> 200; A2A>200; A3>167). CVT-5440 has the potential for asthma research.
    CVT-5440
  • HY-12318R
    IBMX (Standard) 28822-58-4
    IBMX (Standard) is the analytical standard of IBMX. This product is intended for research and analytical applications. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.
    IBMX (Standard)
  • HY-123219
    Salifluor 78417-90-0 98%
    Salifluor is a broad spectrum antimicrobial agent that has been investigated for its abilities to inhibit dental plaque formation. Salifluor can act as an effective anti-inflammatory agent.
    Salifluor
  • HY-123220
    S 1592 25552-58-3 98%
    S 1592 is a compound that possesses bronchodilating and antianaphylactic properties and does not affect gastrointestinal propulsion.
    S 1592
  • HY-123270
    RP23618 207991-30-8 98%
    RP23618 is a non peptidic RANTES antagonist with the IC50 of 3 μM. RP23618 inhibit RANTES-induced chemotaxis of THP-1 cells.
    RP23618
  • HY-123277
    IMB-10 307525-40-2 98%
    IMB-10 is an αMβ2 integrin ligand. IMB-10 inhibits αMβ2-dependent migration and inflammation-induced neutrophil emigration.
    IMB-10
  • HY-123289
    CP-690550A 1243290-37-0 98%
    CP-690550A is an analogue of Tofacitinib (HY-40354). CP-690550A is a dual inhibitor of JAK2 and JAK3.
    CP-690550A
  • HY-123388
    SCH 12223 free base 89109-20-6 98%
    SCH 12223 free base is an orally available drug that protects the gastric and intestinal epithelium from harmful irritants.
    SCH 12223 free base
  • HY-123391
    PD 127443 121502-05-4 98%
    PD 127443 is an inhibitor of 5-lipoxygenase and cyclooxygenase. PD 127443 has anti-inflammatory activity.
    PD 127443
  • HY-123412
    FOL7185 5441-46-3 98%
    FOL7185, an antibacterial agent, is a hit against IspD and IspE enzymes isolated from bacteria.
    FOL7185
  • HY-123505
    Dersalazine sodium 367249-56-7 98%
    Dersalazine (sodium) is a platelet-activating factor (PAF) antagonist. Dersalazine (sodium) can exert intestinal anti-inflammatory activity in rodent colitis models by downregulating IL-17 expression.
    Dersalazine sodium
  • HY-12355R
    Siponimod (Standard) 1230487-00-9
    Siponimod (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research-.
    Siponimod (Standard)
Cat. No. Product Name / Synonyms Application Reactivity