2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P99981
    Mouse IgG2c kappa, Isotype Control 98.25%
    Mouse IgG2c kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgG2cκ antibody.
    Mouse IgG2c kappa, Isotype Control
  • HY-P99983
    Mouse IgG1 (D265A) kappa, Isotype Control 99.52%
    Mouse IgG1 (D265A) kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgG1(D265A)κ antibody.
    Mouse IgG1 (D265A) kappa, Isotype Control
  • HY-P99984
    Mouse IgG1 (N297A) kappa, Isotype Control
    Mouse IgG1 (N297A) kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgG1(N297A)κ antibody.
    Mouse IgG1 (N297A) kappa, Isotype Control
  • HY-P99985
    Mouse IgG3 kappa, Isotype Control
    Mouse IgG3 kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgG3κ antibody.
    Mouse IgG3 kappa, Isotype Control
  • HY-P99997
    Human IgG1 (D270N) kappa, Isotype Control
    Human IgG1 (D270N) kappa, Isotype Control, a human-derived antibody, is an isotype control for human IgG1 (D270N)κ antibody.
    Human IgG1 (D270N) kappa, Isotype Control
  • HY-U00065
    Tritoqualine 14504-73-5 98%
    Tritoqualine is a histidine decarboxylase inhibitor, that inhibits the release of histidine.
    Tritoqualine
  • HY-U00452
    PL553 1456872-74-4 98%
    PL553 is a specific and high-affinity fluorigenic substrate of Leukotriene A4 hydrolase, with a λmax of 210 nm and λem of 410 nm.
    PL553
  • HY-Y0061R
    Oxindole (Standard) 59-48-3
    Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
    Oxindole (Standard)
  • HY-Y0073R
    4-Hydroxyacetophenone (Standard) 99-93-4 99.89%
    4-Hydroxyacetophenone (Standard) is the analytical standard of 4-Hydroxyacetophenone. This product is intended for research and analytical applications. 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer.
    4-Hydroxyacetophenone (Standard)
  • HY-Y0106R
    2,6-Dihydroxyacetophenone (Standard) 699-83-2
    2,6-Dihydroxyacetophenone (Standard) is the analytical standard of 2,6-Dihydroxyacetophenone (HY-Y0106). This product is intended for research and analytical applications. 2,6-Dihydroxyacetophenone, a polyphenolic derivative of Acetophenone (HY-Y0989), is an orally active mTOR inhibitor. 2,6-Dihydroxyacetophenone shows antioxidant activity. 2,6-Dihydroxyacetophenone inhibits cell growth and proliferation in CRC cells. 2,6-Dihydroxyacetophenone arrests at G0/G1 phase of cell cycle, induces apoptosis and suppresses cell migration in CRC cells. 2,6-Dihydroxyacetophenone inhibits xanthine oxidase (XOD) with an IC50 of 1.24 mM. 2,6-dihydroxyacetophenone improves uric acid metabolism in hyperuricemia mice, reduces plasma cholesterol in hypercholesterolemic rats, and inhibits lipid accumulation in HFD-induced obese mice. 2,6-Dihydroxyacetophenone can be used for the study of colorectal cancer (CRC), hyperuricemia and hypercholesterolemia.
    2,6-Dihydroxyacetophenone (Standard)
  • HY-Y0148R
    10-Hydroxydecanoic acid (Standard) 1679-53-4
    10-Hydroxydecanoic acid (Standard) is the analytical standard of 10-Hydroxydecanoic acid. This product is intended for research and analytical applications. 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].
    10-Hydroxydecanoic acid (Standard)
  • HY-Y0152R
    Cinchonine (Standard) 118-10-5
    Cinchonine (Standard) is the analytical standard of Cinchonine. This product is intended for research and analytical applications. Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.
    Cinchonine (Standard)
  • HY-Y0189S
    Methyl Salicylate-d4 1219802-12-6 98%
    Methyl Salicylate-d4 is the deuterium labeled Methyl Salicylate. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products. A systemic acquired resistance (SAR) signal in tobacco. A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor.
    Methyl Salicylate-d4
  • HY-Y0320E
    Dimethyl sulfoxide (suitable for HPLC) 67-68-5 98%
    Dimethyl sulfoxide (suitable for HPLC) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide (suitable for HPLC) is suitable for HPLC.
    Dimethyl sulfoxide (suitable for HPLC)
  • HY-Y0470R
    Semicarbazide hydrochloride (Standard) 563-41-7
    Semicarbazide (hydrochloride) (Standard) is the analytical standard of Semicarbazide (hydrochloride). This product is intended for research and analytical applications. Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles.
    Semicarbazide hydrochloride (Standard)
  • HY-Y0537J
    Potassium chloride, meets analytical specification of Ph. Eur., BP, USP, FCC, E508, ≤0.0001% Al 7447-40-7 98%
    Potassium chloride is a inorganic compound.
    Potassium chloride, meets analytical specification of Ph. Eur., BP, USP, FCC, E508, ≤0.0001% Al
  • HY-Y0836R
    Diethyl succinate (Standard) 123-25-1 98%
    Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings.
    Diethyl succinate (Standard)
  • HY-Y0946R
    Acetamide (Standard) 60-35-5
    Acetamide (Standard) is the analytical standard of Acetamide. This product is intended for research and analytical applications. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies.
    Acetamide (Standard)
  • HY-Y1129S
    3-Hydroxypyridine-d4 98%
    3-Hydroxypyridine-d4 is the deuterium labeled 3-Hydroxypyridine (HY-Y1129). 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation.
    3-Hydroxypyridine-d4
  • HY-Y1155S
    Hexamethylphosphoramide-d18 51219-90-0 98%
    Hexamethylphosphoramide-d18 is the deuterium labeled Hexamethylphosphoramide (HY-Y1155). Hexamethylphosphoramide is an orally active polar aprotic solvent, flame retardant additive, and carcinogen. Hexamethylphosphoramide undergoes cytochrome P-450-mediated N-demethylation to Formaldehyde. Hexamethylphosphoramide induces DNA-protein crosslinks. Hexamethylphosphoramide has been linked to nasal tumors (squamous cell carcinoma, adenoid squamous cell carcinoma), squamous metaplasia, rhinitis, tracheitis, and reversible and irreversible infertility.
    Hexamethylphosphoramide-d18
Cat. No. Product Name / Synonyms Application Reactivity