2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-119469
    Aceclofenac ethyl ester 139272-67-6 98%
    Aceclofenac ethyl ester is an impurity of Aceclofenac (HY-B0634).
    Aceclofenac ethyl ester
  • HY-119494
    Commendamide 193825-78-4 98%
    Commendamide is a GPCR G2A/GPR132 agonist (EC50: 11.8 μM). Commendamide can be used for research of autoimmunity and atherosclerosis.
    Commendamide
  • HY-119627
    Cajucarinolide 147742-03-8 98%
    Cajucarinolide is anti-Inflammatory diterpene that can be isolated from Croton cajucara.
    Cajucarinolide
  • HY-119666
    Rooperol 83644-00-2 98%
    Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects.
    Rooperol
  • HY-119799
    UK-500001 582332-31-8 98%
    UK-500001 is an orally active inhibitor for phosphodiesterase 4 (PDE4), which inhibits PDE4D3 (IC50 is 0.28 nM), PDE4B2 (IC50 is 22.8 nM), PDE4A4 (IC50 is 26.1 nM) and PDE4C2 (IC50 is 271 nM). UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-α and IFN-γ release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease (COPD) and asthma.
    UK-500001
  • HY-119831
    Rohitukine 71294-60-5 98%
    Rohitukine is an alkaloid with analgesic and anti-inflammatory activities.
    Rohitukine
  • HY-120050
    GK470 1621517-53-0 98%
    GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels.
    GK470
  • HY-120232
    ABT-963 266320-83-6 98%
    ABT-963 is a selective cyclooxygenase-2 (COX-2) inhibitor for the study of pain and inflammation.
    ABT-963
  • HY-120268
    SLM6031434 1897379-33-7 98%
    SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 has the potential for renal fibrosis research.
    SLM6031434
  • HY-120450
    CL-55 1370706-59-4 98%
    CL-55 is an inhibitor for type three secretion system of Chlamydia trachomatis, that blocks the effector molecules delivery of bacteria into host cells. CL-55 ameliorates the C. trachomatis infection and inflammation in mice.
    CL-55
  • HY-120471
    AM-0687 1259522-94-5 98%
    AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy.
    AM-0687
  • HY-120476
    JNJ-39729209 1160606-90-5 98%
    JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs.
    JNJ-39729209
  • HY-120486
    LY203647 122009-61-4 98%
    LY203647 is an orally active antagonist for leukotriene receptor LTD4 and LTE4. LY203647 can be used in research about asthma and other inflammation diseases.
    LY203647
  • HY-120533
    Syk-IN-11 1194954-83-0 98%
    Syk-IN-11 (BIIB-057) is a selective Syk inhibitor with an IC50 Of 13 nM. Syk-IN-11 can be used in the study of arthritis and chronic lymphocytic leukemia.
    Syk-IN-11
  • HY-120606
    A-78773 141579-67-1 98%
    A-78773 is a 5-lipoxygenase inhibitor. A-78773 can inhibit the formation of LTB4 in human whole blood and human neutrophils, with IC50 values of 85 nM and 20 nM, respectively. A-78773 can be used in the study of inflammation-related diseases.
    A-78773
  • HY-12066R
    GSK1292263 (Standard) 1032823-75-8
    GSK1292263 (Standard) is the analytical standard of GSK1292263. This product is intended for research and analytical applications. GSK-1292263 is an orally available GPR119 agonist with pEC50s of 6.9 and 6.7 for human and rat GPR119, respectively. GSK-1292263 can be used for the research of type 2 diabetes mellitus (T2DM).
    GSK1292263 (Standard)
  • HY-120755
    LY290324 146554-87-2 98%
    LY290324 is a potent and orally active leukotriene D4 (LTD4) antagonist. LY290324 reduces LTC4, LTD4 and LTE4 (HY-113465)-induced bronchospasm. LY290324 has the potential for the research of antigen-induced bronchospasm.
    LY290324
  • HY-12085R
    Apremilast (Standard) 608141-41-9
    Apremilast (Standard) is the analytical standard of Apremilast. This product is intended for research and analytical applications. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.
    Apremilast (Standard)
  • HY-120865
    1,3-PBIT dihydrobromide 200716-66-1 98%
    1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
    1,3-PBIT dihydrobromide
  • HY-12100R
    Umeclidinium bromide (Standard) 869113-09-7
    Umeclidinium (bromide) (Standard) is the analytical standard of Umeclidinium (bromide). This product is intended for research and analytical applications. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
    Umeclidinium bromide (Standard)
Cat. No. Product Name / Synonyms Application Reactivity