2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118484
    (RS)-Sakuranetin 520-29-6 98%
    (RS)-Sakuranetin is the racemate of Sakuranetin (HY-N3006).
    (RS)-Sakuranetin
  • HY-118527
    Fenirofibrate 54419-31-7 98%
    Fenirofibrate (LF 2151), a metabolite of Fenofibrate (HY-17356), is an orally active fibrate, used in the study of hypertriglyceridemia.
    Fenirofibrate
  • HY-118695
    IRL-3630 173189-01-0 98%
    IRL-3630 (Compound 3) is an ETA/ETB antagonist (Ki: 1.9 and 1.2 nM).
    IRL-3630
  • HY-118734
    IK-862 478911-60-3 98%
    IK-862 is a selective inhibitor of TACE.
    IK-862
  • HY-118754
    13,14-Dihydro-15-keto PGF1α 29044-75-5 98%
    13,14-Dihydro-15-keto PGF1α is a metabolite of PGF1α.
    13,14-Dihydro-15-keto PGF1α
  • HY-118756
    Anirolac 66635-85-6
    Anirolac (RS37326) is a nonsteroidal anti-inflammatory agent with analgesic activity. Anirolac showed analgesic efficacy comparable to that of naproxen in suppressing moderate or severe postpartum uterine pain. Anirolac induced significantly higher analgesia scores than placebo within 6 hours, especially at the 100 mg dose. Anirolac effectively relieved pain and showed a stronger analgesic effect than placebo in every assessment.
    Anirolac
  • HY-118782
    Ibuprofen diethylaminoethyl ester 64622-41-9 98%
    Ibuprofen diethylaminoethyl ester is an acidic antiinflammatory drug with anesthetic effect.
    Ibuprofen diethylaminoethyl ester
  • HY-118788
    N-Desmethyl rosiglitazone 257892-31-2 98%
    N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone (HY-17386), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone (HY-17386).
    N-Desmethyl rosiglitazone
  • HY-118848
    A63162 111525-11-2 98%
    A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease.
    A63162
  • HY-118910
    AHR-14310C 119810-68-3 98%
    AHR-14310C is a potent, long-acting, nonsedating H1-antihistamine that prevents antigen-induced mucus formation in sensitive rats.
    AHR-14310C
  • HY-118979
    L-691678 144210-49-1 98%
    L-691678 can bind to FLAP by recognizing the amino acid residues of 5-lipoxygenase-activating protein (FLAP), thereby inhibiting leukotriene biosynthesis. L-691678 can be used in the study of leukotriene-related diseases such as allergies, asthma, and inflammation.
    L-691678
  • HY-118984
    CRX-526 245515-64-4 98%
    CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-α induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model).
    CRX-526
  • HY-119035
    R-75317 115406-25-2 98%
    R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis.
    R-75317
  • HY-119086
    L-651392 93211-49-5 98%
    L-651392 is an orally active and specific 5-lipoxygenase inhibitor that inhibits the production of leukotrienes. L-651392 controls the inflammatory process in Escherichia coli pyelonephritis by preventing inflammatory cells from reaching the site of infection and protecting the renal tubules from inflammation-related damage during pyelonephritis.
    L-651392
  • HY-119120
    JTK-101 503048-34-8 98%
    JTK-101 is a selective HIV inhibitor. JTK-101 selectively reduces HIV-1 mRNA synthesis by inhibiting Tat cofactors, including CDK9 and cyclin T1, thereby suppressing the transcriptional activity of HIV-1. JTK-101 may be used in the field of anti-HIV virus research.
    JTK-101
  • HY-119158
    VU0652925 1476847-58-1 98%
    VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC50 values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation.
    VU0652925
  • HY-119218
    LH 1 67190-52-7 98%
    LH 1 is a potent immunostimulant used for the anti-PVP (polyvinylpyrrolidone) response in athymic mice.
    LH 1
  • HY-119221
    AUY954 820240-77-5 98%
    AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis.
    AUY954
  • HY-119279
    VUF 10214 848837-33-2 98%
    VUF 10214 is a H4 receptor ligand with a pKi of 8.25. VUF 10214 exhibits significant anti-inflammatory activity in a carrageenan-induced paw edema rat model and can be used for research in the field of inflammatory diseases.
    VUF 10214
  • HY-119466
    Broperamole 33144-79-5 98%
    Broperamole is an anti-inflammatory and antipyretic agent. Broperamole has systemic and toical antiinflammatory activity.
    Broperamole
Cat. No. Product Name / Synonyms Application Reactivity