2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-115676
    GSK199 analog hydrochloride 2048226-46-4 98%
    GSK199 analog hydrochloride belongs to a class of compounds that inhibit PAD4 (guanidinoarginine deiminase 4). GSK199 analog hydrochloride has potential uses in diseases including rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosus, and psoriasis.
    GSK199 analog hydrochloride
  • HY-115855
    Ro 31-4639 125131-65-9 98%
    Ro 31-4639 is a potent phospholipase A2 inhibitor with an IC50 of 1.5 μM.
    Ro 31-4639
  • HY-116005
    A-286501 483341-15-7 98%
    A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents.
    A-286501
  • HY-116029
    Tolmetin β-D-Glucuronide 71595-19-2 98%
    Tolmetin β-D-Glucuronide (Tolmetin glucuronide) is the major phase II metabolite of Tolmetin (HY-B1799).
    Tolmetin β-D-Glucuronide
  • HY-116080
    SB 210661 162750-10-9 98%
    SB 210661 is a potent and selective 5-lipoxygenase inhibitor.
    SB 210661
  • HY-116115
    17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 1233715-33-7 98%
    17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy.
    17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid
  • HY-116164
    A-79175 141579-87-5 98%
    A-79175 is a potent 5-lipoxygenase inhibitor that inhibits leukotriene formation. A-79175 is promising for research of various allergic and inflammatory diseases including asthma, allergic rhinitis, rheumatoid arthritis and inflammatory bowel disease.
    A-79175
  • HY-116262
    SCH 51866 167298-74-0 98%
    SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM). SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension.
    SCH 51866
  • HY-116426
    IDT 18138-19-7 98%
    IDT is a safe and effective TNFα and innate immune system modulator. IDT significantly reduced paired helical filament tau and fibrillar amyloid accumulation and increased the infiltrating neutrophil population while reducing TNFα expression in this population. IDT can be used in Alzheimer's disease research.
    IDT
  • HY-116582
    8-Nitroguanine 168701-80-2 98%
    8-Nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species, is a potential biomarker for progression of malignant fibrous histiocytoma.
    8-Nitroguanine
  • HY-116722
    (2E)-4-Hydroperoxy-2-nonenal 7439-43-2 98%
    (2E)-4-Hydroperoxy-2-nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, and can be used as a marker of oxidative stress.
    (2E)-4-Hydroperoxy-2-nonenal
  • HY-116958
    SCH 206272 226915-43-1 98%
    SCH 206272 is a selective antagonist of the tachykinin (NK) receptor. SCH 206272 inhibits binding at human tachykinin NK(1), NK(2), and NK(3) receptors (Ki = 1.3, 0.4, and 0.3 nM, respectively). SCH 206272 has an orally active.
    SCH 206272
  • HY-117131
    ZINC17167211 592539-21-4 98%
    ZINC17167211 is a potent PPAR-α agonist (EC50=0.16 nM) that can be used in the study of diabetes, hyperlipidemia, and inflammatory diseases.
    ZINC17167211
  • HY-117225
    Pantoprazole sulfone 127780-16-9 98%
    Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor Pantoprazole (HY-17507).
    Pantoprazole sulfone
  • HY-117358
    KW-5805 113302-01-5 98%
    KW-5805 is an anti-ulcer agent that promotes the biosynthesis, storage and secretion of gastric mucus, improves gastric mucosal hemodynamics, and inhibits the decrease in gastric mucosal blood volume and mucosal oxygenation caused by steroid shock.
    KW-5805
  • HY-117368
    AL-8417 180472-20-2 98%
    AL-8417 ((2R)-AL-5898) is a potent inhibitor of Cyclooxygenase (COX), with IC50 of 120 μM, that plays an important role in inflammatory response.
    AL-8417
  • HY-117429
    Se-Aspirin 1850293-95-6 98%
    Se-Aspirin is a hybrid molecule of selenium and Aspirin (HY-14654). Se-Aspirin reduces the viability of cancer cell lines, particularly colorectal cancer cells.
    Se-Aspirin
  • HY-117557
    LY306669 153227-04-4 98%
    LY306669 is a potent and selective leukotriene B4 (LTB4) receptor antagonist that can be used for the research of lung injury.
    LY306669
  • HY-117573
    1Z105 1438280-73-9 98%
    1Z105 is an oral active TLR4/MD2 ligand. 1Z105 enhances dendritic cell maturation and antigen presentation and prevents rthritis.
    1Z105
  • HY-117591
    L 684248 156728-18-6 98%
    L-684248 is an inhibitor of human leukocyte elastase (HLE). L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research.
    L 684248
Cat. No. Product Name / Synonyms Application Reactivity