2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P10274
    CM05 98%
    CM05 is a bromo-fatty acid. CM05 can be used to modify ornithodoros moubata complement inhibitor (OmCI) and extend the half-life of OmCI.
    CM05
  • HY-P10297
    PLP (190-209) 165549-59-7 98%
    PLP (190-209) is a myelin proteolipid protein (PLP) fragment. PLP (190-209) is used to induce experimental autoimmune encephalomyelitis (EAE) animal models for multiple sclerosis research.
    PLP (190-209)
  • HY-P10314
    [Leu144]-PLP (139-151) 202462-61-1 98%
    [Leu144]-PLP (139-151) (L144-PLP(139-151)) is a peptide ligand of T cell receptor. [Leu144]-PLP (139-151) is a TCR antagonist for encephalitogenic Th1 clones, blocking their activation.
    [Leu144]-PLP (139-151)
  • HY-P10321
    HBP08 2490442-13-0 98%
    HBP08 is a selective inhibitor of CXCL12/HMGB1 interaction. HBP08 has a high affinity for HMGB1 (Kd=0.8 μM). HBP08 inhibits CXCL12-mediated cell migration.
    HBP08
  • HY-P10333
    LIH383 2866266-58-0 98%
    LIH383 is an agonist of ACKR3 (CXCR7) (EC50=0.61 nM). LIH383 efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling.
    LIH383
  • HY-P10339
    SMCY peptide 169312-12-3 98%
    SMCY peptide inhibits the binding of iodinated standard peptide to HLA-B7 with an IC50 of 34 nM. As an epitope of the H-Y antigen, SMCY peptide can be presented by the HLA-B7 molecule and recognized by specific T cells, leading to transplant rejection.
    SMCY peptide
  • HY-P10343
    Soybean peptide QRPR 125585-15-1 98%
    Soybean peptide QRPR is an agonist of Autophagy. Soybean peptide QRPR activates cellular autophagy by upregulating the expression and activity of PIK3, AKT, and mTOR. Soybean peptide QRPR can reduce the inflammatory response.
    Soybean peptide QRPR
  • HY-P10346
    smMLCK peptide 172960-20-2 98%
    smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK). The smMLCK peptide mimics the substrate and competitively inhibits the binding of the actual substrate to the enzyme, thereby inhibiting the kinase activity. This inhibition prevents the phosphorylation of the myosin light chain, thus inhibiting muscle contraction.
    smMLCK peptide
  • HY-P10349
    Pap12-6 98%
    Pap12-6 is a 12-mer peptide derived from the antimicrobial peptide Papiliocin of yellow butterfly larva. Pap12-6 kills bacteria by penetrating and disrupting their membranes, exhibiting strong antibacterial activity. Pap12-6 exerts its anti-inflammatory effects through the TLR4-mediated NF-κB signaling pathway.
    Pap12-6
  • HY-P10350
    PapRIV 98%
    PapRIV is an agonist of BV-2 microglial cells, capable of activating microglial cells through an NF-κB-dependent pathway. PapRIV induces the expression of pro-inflammatory cytokines such as IL-6 and TNFα and increases the production of reactive oxygen species (ROS). PapRIV can cross the blood-brain barrier.
    PapRIV
  • HY-P10353
    d-(RYTVELA) 868844-53-5 98%
    d-(RYTVELA) is a specific inhibitor of human thymocyte proliferation with an IC50 of 1 nM. d-(RYTVELA) inhibits IL-1–induced signaling pathways.
    d-(RYTVELA)
  • HY-P10354
    SPA4 1343908-95-1 98%
    SPA4 is a TLR4-interacting peptide. SPA4 inhibits the LPS-induced TNF-α cytokine response without effect the cell viability or size.
    SPA4
  • HY-P10357
    TAT-CBD3 1355359-36-2 98%
    TAT-CBD3, a 15-amino acid peptide from CRMP2, fused to the TAT cell-penetrating motif of the HIV-1 protein, disrupts CRMP2-NMDAR interaction without change in NMDAR localization.
    TAT-CBD3
  • HY-P10361
    Temporin-GHc 2755770-49-9 98%
    Temporin-GHc has an antibacterial activity with MBIC50 value of 6 μM and antibiofilm activity with MBEC50 value of 25 μM at 24 h.
    Temporin-GHc
  • HY-P10364
    Ubiquicidin(29-41) 216867-99-1 98.69%
    Ubiquicidin(29-41) is an antimicrobial peptide highly homologous to S30. Ubiquicidin(29-41) targets bacterial and fungal. Ubiquicidin(29-41) can be used as a membrane-specific infection localizer.
    Ubiquicidin(29-41)
  • HY-P10371
    PKHB1 1505523-99-8 98%
    PKHB1 is a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS production, intracellular Ca2+ accumulation, as well calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation through immunogenic cell death induction in breast cancer cells.
    PKHB1
  • HY-P10382
    M133 peptide 98%
    M133 peptide is a coronavirus-specific CD4 T cell epitope. M133 peptide is immunodominant in mice infected with the neurotropic coronavirus (the JHM strain of mouse hepatitis virus). M133 peptide forms a complex with MHC II molecules, which is recognized by specific TCRs, thereby activating CD4 T cells.
    M133 peptide
  • HY-P10400
    AtPep1 902781-11-7 98%
    AtPep1 is a plant elicitor peptide. AtPep1 activates transcription of the defensive gene defensin (PDF1.2) and activates the synthesis of H2O2, which are components of the innate immune response against pathogens. AtPep1 can be isolated from extracts of Arabidopsis leaves.
    AtPep1
  • HY-P10403
    IGFBP-3 peptide 319426-26-1 98%
    IGFBP-3 peptide is a 18-amino acid insulin-like growth factor binding protein-3. IGFBP-3 peptide binds Humanin (HY-P1928) and Hyaluronan (HY-B0633A), blocks the interaction of CD44 and hyaluronan.
    IGFBP-3 peptide
  • HY-P10414
    Klotho-derived peptide 1 98%
    Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model.
    Klotho-derived peptide 1
Cat. No. Product Name / Synonyms Application Reactivity