2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116084S1
    Trimethylamine-N-oxide-13C3 98%
    Trimethylamine-N-oxide-13C3 is the 13C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
    Trimethylamine-N-oxide-13C3
  • HY-117275S1
    Meclofenamic acid-13C6 98%
    Meclofenamic acid-13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
    Meclofenamic acid-13C6
  • HY-118545AR
    Butamirate citrate (Standard) 18109-81-4
    Butamirate citrate (Standard) is the analytical standard of Butamirate citrate (HY-118545A). This product is intended for research and analytical applications. Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma.
    Butamirate citrate (Standard)
  • HY-121272AS
    Difloxacin-d3 hydrochloride trihydrate 98%
    Difloxacin-d3 (hydrochloride trihydrate) is a deuterium labeled Difloxacin. Difloxacin is an antimicrobial agent.
    Difloxacin-d3 hydrochloride trihydrate
  • HY-122494AR
    Bialaphos sodium (Standard) 71048-99-2
    Bromocriptine (mesylate) (Standard) is the analytical standard of Bromocriptine (mesylate). This product is intended for research and analytical applications. Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
    Bialaphos sodium (Standard)
  • HY-126047AR
    (R,S)-Anatabine (Standard) 2743-90-0
    (R,S)-Anatabine (Standard) is the analytical standard of (R,S)-Anatabine (HY-126047A). This product is intended for research and analytical applications. (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use.
    (R,S)-Anatabine (Standard)
  • HY-126047AS
    (R,S)-Anatabine-d4 1020719-11-2 98%
    (R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use.
    (R,S)-Anatabine-d4
  • HY-128749AR
    D-Glucaric acid tetrahydrate (Standard) 5793-89-5
    D-Glucaric acid tetrahydrate (Standard) (Calcium D-glucarate tetrahydrate (Standard)) is the analytical standard of D-Glucaric acid tetrahydrate (HY-128749A). This product is intended for research and analytical applications. D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the D-glucuronic acid pathway in mammals. D-Glucaric acid tetrahydrate is present in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can inhibit tumor cell proliferation and inflammation, and induce apoptosis.
    D-Glucaric acid tetrahydrate (Standard)
  • HY-131104AS
    Brombuterol-d9 hydrochloride 1353867-94-3 98%
    Brombuterol-d9 (hydrochloride) is a deuterium labeled Brombuterol hydrochloride. Brombuterol hydrochloride is a β-adrenergic receptor agonist.
    Brombuterol-d9 hydrochloride
  • HY-133968S1
    24-Methylenecholesterol-13C 98%
    24-Methylenecholesterol-13C (Ostreasterol-13C) is the 13C labeled 24-Methylenecholesterol (HY-133968). 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth.
    24-Methylenecholesterol-13C
  • HY-13571AS1
    Beclometasone dipropionate-d10 98%
    Beclometasone dipropionate-d10 is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release.
    Beclometasone dipropionate-d10
  • HY-135731AS
    4-Methylamino antipyrine-d3 hydrochloride 98%
    4-Methylamino antipyrine-d3 (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.
    4-Methylamino antipyrine-d3 hydrochloride
  • HY-135810S1
    Cletoquine-d4-1 1216461-56-1 98%
    Cletoquine-d4-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment.
    Cletoquine-d4-1
  • HY-138300GL
    ALC-0159 (GMP Like) 1849616-42-7 98%
    ALC-0159 (GMP Like) is the GMP Like class ALC-0159 (HY-138300). ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient.
    ALC-0159 (GMP Like)
  • HY-147338S2
    5-Methylcytidine 5′-triphosphate-d8 trisodium 98%
    5-Methylcytidine 5'-triphosphate-d8 trisodium is the deuterium-labeled form of 5-Methylcytidine 5'-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5'-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5'-triphosphate trisodium can be used to replace unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells.
    5-Methylcytidine 5′-triphosphate-d8 trisodium
  • HY-148144AR
    Clobutinol hydrochloride (Standard) 1215-83-4
    Clobutinol (hydrochloride) (Standard) is the analytical standard of Clobutinol (hydrochloride). This product is intended for research and analytical applications. Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research.
    Clobutinol hydrochloride (Standard)
  • HY-17042AS1
    Cetirizine-d8 dihydrochloride 2070015-04-0 98%
    Cetirizine-d8 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
    Cetirizine-d8 dihydrochloride
  • HY-B0426AS1
    (Z)-Olopatadine-d3 hydrochloride 98%
    (Z)-Olopatadine-d3 (hydrochloride) is deuterium labeled Olopatadine (hydrochloride).
    (Z)-Olopatadine-d3 hydrochloride
  • HY-B0426AS2
    Olopatadine-d6 hydrochloride 98%
    Olopatadine-d6 (ALO4943A-d6; KW4679-d6) hydrochloride is deuterium-labeled Olopatadine (hydrochloride) (HY-B0426A).
    Olopatadine-d6 hydrochloride
  • HY-B0524AS1
    Betahistine-13C,d3 dihydrochloride 98%
    Betahistine-13C,d3 (dihydrochloride) is the 13C- and deuterium labeled Betahistine (dihydrochloride). Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).
    Betahistine-13C,d3 dihydrochloride
Cat. No. Product Name / Synonyms Application Reactivity