2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N16637
    (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside 408324-05-0
    (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside is a diarylheptanol glycoside compound isolated from Tacca plantaginea. (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside significantly inhibit TNF-α-induced NF-κB transcriptional activity (IC50 = 9.4 μM). (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside significantly activates PPAR transcriptional activity (EC50 = 9.9 μM) and has a specific activating effect on PPAR β(δ) (EC50 = 23.1 μM). (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside is non-toxic to cells at the tested concentration. (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside can be used for research on inflammatory conditions.
    (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside
  • HY-N16638
    Zizyvoside I 81425-28-7
    Zizyvoside I is a compound that can be extracted from Dioscorea septemloba. Zizyvoside I is a potential anti-inflammatory agent.
    Zizyvoside I
  • HY-N16640
    Anol glucoside 120396-85-2 98%
    Anol glucoside is a phenolic glucose glycoside compound found in Cleidion spiciflorum. Anol glucoside has potential antibacterial, anti-inflammatory and antimalarial activities.
    Anol glucoside
  • HY-N16648
    sEH-IN-22 2305966-67-8
    sEH-IN-22 (Compound 1) is a soluble epoxide hydrolase (sEH) inhibitor (IC50 = 1.1 μM) found in Rubia philippinensis. sEH-IN-22 exhibits anti-inflammatory, analgesic and blood pressure-regulating effects. sEH-IN-22 can be used for the researches of inflammation, neurological and cardiovascular disease.
    sEH-IN-22
  • HY-N16652
    Foeniculoside I 168010-10-4 98%
    Foeniculoside I is a stilbene trimer glycoside compound found in Foeniculum vulgare. Foeniculoside I has strong antioxidant activity and moderate hyaluronidase inhibitory activity. Foeniculoside I can be used for the researches of cancer, inflammation and immunology.
    Foeniculoside I
  • HY-N16658
    Asperilin 7044-35-1
    Asperilin is an orally active sesquiterpene lactone. Asperilin is an effective hydroxyl radical scavenger. Asperilin significantly enhance the lipid peroxidation levels of liver microsomes in various systems. Asperilin leads to a significant decrease in liver glutathione (GSH) levels and an increase in glutathione peroxidase (GPx) activity. Asperilin can be used for research on inflammatory conditions.
    Asperilin
  • HY-N16659
    Tetradeca-4E,8E,12E-triene-10-yne-1,6,7-triol 119875-18-2
    Tetradeca-4E,8E,12E-triene-10-yne-1,6,7-triol (Compound 9) is a polyyne compound found in Codonopsis pilosula. Tetradeca-4E,8E,12E-triene-10-yne-1,6,7-triol has potential immunomodulatory effect.
    Tetradeca-4E,8E,12E-triene-10-yne-1,6,7-triol
  • HY-N16660
    Tangshenoside V 1050399-39-7
    Tangshenoside V is a phenylpropanoid glucoside found in the roots of Codonopsis tangshen. Tangshenoside V has potential anti-inflammatory, immunomodulatory and mucosal protective effects. Tangshenoside V can be used for the researches of inflammation, immunology and neurological disease.
    Tangshenoside V
  • HY-N16662
    erythro-Anethole glycol 103687-27-0 98%
    erythro-Anethole glycol (Compound 11) is an aromatic diol compound found in Foeniculi Fructus. erythro-Anethole glycol has potential antioxidant activity and can be used for the researches of inflammation, cardiovascular and neurological disease.
    erythro-Anethole glycol
  • HY-N16663
    Plantagiolide C 913263-86-2
    Plantagiolide C is a withanolide found in Tacca plantaginea. Tacca plantaginea has analgesic, antipyretic and anti-inflammatory effects.
    Plantagiolide C
  • HY-N16664
    Chantriolide C 1206850-19-2
    Chantriolide C is a withanolide glucoside found in Tacca chantrieri. Tacca chantrieri has anti-inflammatory and gastrointestinal mucosa protection effects.
    Chantriolide C
  • HY-N16665
    6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene 1353042-00-8
    6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene (Compound 6) is a diterpenoid found in Premna obtusifolia. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene exhibits antibacterial against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin-resistant Enterococcus faecalis (VRE) (MIC = 37.5 μg/mL). 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can significantly inhibit the release of the inflammatory mediator NO, with an IC50 value of 29.1 μM. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can be used for the researches of infection and inflammation.
    6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene
  • HY-N16668
    (3R,5S)-5'-Methoxyoctahydrocurcumin 718638-77-8
    (3R,5S)-5'-Methoxyoctahydrocurcumin (Compound 4) is a diarylheptanoidfound in Curcuma comosa. (3R,5S)-5'-Methoxyoctahydrocurcumin exhibits strong antiallergic activity by inhibiting β-hexosaminidase release and the degranulation of mast cells. (3R,5S)-5'-Methoxyoctahydrocurcumin can be used for the research of immunology, such as asthma.
    (3R,5S)-5'-Methoxyoctahydrocurcumin
  • HY-N16739
    Circumdatin C 223130-61-8
    Circumdatin C is an alkaloid. Circumdatin C shows inhibitory effects against LPS-stimulated NO production. Circumdatin C inhibits AChE activity with an IC50 value of 13.9 μM. Circumdatin C can be used in the research of Alzheimer's disease.
    Circumdatin C
  • HY-N16849
    Myristinin A 145904-69-4
    Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC50 of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC50 of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis.
    Myristinin A
  • HY-N16865
    Myristinin B/C
    Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit COX-2 activity with an IC50 of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candida albicans with an IC50 of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis.
    Myristinin B/C
  • HY-N1921R
    Edpetiline (Standard) 32685-93-1
    Edpetiline (Standard) is the analytical standard of Edpetiline. This product is intended for research and analytical applications. Edpetiline is a principal alkaloid from P. eduardi. Edpetiline has significant antiinflammatory effects.
    Edpetiline (Standard)
  • HY-N1934R
    Dihydroberberine (Standard) 483-15-8
    Dihydroberberine (Standard) is the analytical standard of Dihydroberberine. This product is intended for research and analytical applications. Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy.
    Dihydroberberine (Standard)
  • HY-N1942R
    5-O-Demethylnobiletin (Standard) 2174-59-6
    5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM.
    5-O-Demethylnobiletin (Standard)
  • HY-N1957R
    Gamma-Mangostin (Standard) 31271-07-5
    Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes.
    Gamma-Mangostin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity