2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W756637
    Ibufenac-13C6 98%
    Ibufenac-13C6 (Dytransin-13C6) is the 13C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis.
    Ibufenac-13C6
  • HY-W759719
    21-Desacetyldeflazacort-d4 98%
    21-Desacetyldeflazacort-d4 (21-desDFZ-d4) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085). 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.
    21-Desacetyldeflazacort-d4
  • HY-W759997
    Reproterol-d3 98%
    Reproterol-d3 is the deuterium labeled Reproterol (HY-135490). Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research.
    Reproterol-d3
  • HY-W766497
    Alpha-Zearalenol-d7 98%
    Alpha-Zearalenol-d7 is the deuterium labeled α-Zearalenol (HY-N6710). α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER). α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects.
    Alpha-Zearalenol-d7
  • HY-W766920
    Olsalazine Disodium-13C12 98%
    Olsalazine disodium-13C12 is the 13C-labeled Olsalazine disodium (HY-B0174). Olsalazine Disodium is an anti-inflammatory compound that works in inflammatory bowel disease and ulcerative colitis.
    Olsalazine Disodium-13C12
  • HY-W767865
    Cyclic GMP sodium-13C5 98%
    Cyclic GMP sodium-13C5 is the 13C-labeled Cyclic GMP sodium (HY-113469A). Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases.
    Cyclic GMP sodium-13C5
  • HY-W768336
    Gluconate sodium-13C6 2687960-00-3 98%
    Gluconate sodium-13C6 (D-Gluconic acid sodium salt-13C6) is the 13C-labeled Gluconate sodium (HY-B1092A). Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury.
    Gluconate sodium-13C6
  • HY-W768856
    Artemether-13C,d3 98%
    Artemether-13C,d3 (Dihydroqinghaosu methyl ether-13C,d3) is the deuterium and 13C-labeled Artemether (HY-N0402). Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria.
    Artemether-13C,d3
  • HY-W775009
    Imidazole salicylate 36364-49-5 98%
    Imidazole salicylate is a nonsteroidal anti-inflammatory drug that can be used to study cirrhosis and ascites.
    Imidazole salicylate
  • HY-W777360
    Harman-13C2,15N 1189461-56-0 98%
    Harman-13C2,15N is 13C and 15N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC50 values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF).
    Harman-13C2,15N
  • HY-W777393
    Umbelliferone-13C6 1189992-05-9 98%
    Umbelliferone-13C6 (7-Hydroxycoumarin-13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.
    Umbelliferone-13C6
  • HY-W777458
    Fluorene-13C6 1189497-69-5 98%
    Fluorene-13C6 is the 13C-labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders.
    Fluorene-13C6
  • HY-W777496
    Saccharin-13C6 1286479-01-3 98%
    Saccharin-13C6 is the 13C-labeled Saccharin (HY-Y0272). Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties.
    Saccharin-13C6
  • HY-W778002
    (S)-(+)-Ketoprofen-13C,d3 1330260-99-5 98%
    (S)-(+)-Ketoprofen-13C,d3 is the deuterium and 13C-labeled S-(+)-Ketoprofen (HY-B2137). S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
    (S)-(+)-Ketoprofen-13C,d3
  • HY-W778179
    Benoxaprofen-13C,d3 1329840-53-0 98%
    Benoxaprofen-13C,d3 (LRCL 3794-13C,d3) is the deuterium and 13C-labeled Benoxaprofen (HY-13568). Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation.
    Benoxaprofen-13C,d3
  • HY-W778335
    Dimethyl Phthalate-13C2 1346598-73-9 98%
    Dimethyl Phthalate-13C2 (DMP-13C2) is the 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats.
    Dimethyl Phthalate-13C2
  • HY-W779969
    2-Acetyl-4-tetrahydroxybutyl imidazole-13C6 1448358-08-4 98%
    2-Acetyl-4-tetrahydroxybutyl imidazole-13C6 is the 13C-labeled 2-Acetyl-4-tetrahydroxybutyl imidazole (HY-14113). 2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.
    2-Acetyl-4-tetrahydroxybutyl imidazole-13C6
  • HY-W782193
    Sulcatone-d5 55320-91-7 98%
    Sulcatone-d5 (6-Methyl-5-hepten-2-one-d5) is the deuterium labeled Sulcatone (HY-W010435). Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis.
    Sulcatone-d5
  • HY-W796158
    Z-DEVD-CMK 250584-13-5 98%
    Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro.
    Z-DEVD-CMK
  • HY-W840250
    3,5-Dimethyl-4-phenylisoxazole 4345-46-4 98%
    3,5-Dimethyl-4-phenylisoxazole (3,5-Dimethyl-4-phenyl-1,2-oxazole) is a heterocyclic compound that serves as a molecular structural unit, exhibiting anti-inflammatory, anti-tumor, anti-bacterial, and anti-fungal properties, along with the capacity to modulate the immune system.
    3,5-Dimethyl-4-phenylisoxazole
Cat. No. Product Name / Synonyms Application Reactivity