2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N15845
    C14 Galactosyl(ß) ceramide (d18:1/14:0) 38836-86-1
    C14 Galactosyl(β) ceramide (d18:1/14:0) is a β-Glucosyl ceramide.
    C14 Galactosyl(ß) ceramide (d18:1/14:0)
  • HY-N15846
    VSA 1 2489675-55-8
    VSA 1, a semisynthetic QS-21 (HY-101092) analog, is a saponin adjuvant. VSA 1 potentiates antigen-specific IgG1 and IgG2a immune responses in BALB/c mice, indicating a mixed Th1/Th2 immune response. VSA 1 significantly improves vaccine efficacy after primary immunization and enhances homologous protection.
    VSA 1
  • HY-N15882
    16:0 DNP Cap PE monoammonium 474943-10-7
    16:0 DNP Cap PE monoammonium is an antigenic lipid that plays a role in promoting antigen presentation on lipid bilayers.
    16:0 DNP Cap PE monoammonium
  • HY-N15893
    α-Galactosyl FP20 sodium 3056013-94-3 98%
    α-Galactosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Galactosyl FP20 sodium
  • HY-N15945
    C14 Glucosyl(ß) ceramide (d18:1/14:0) 126327-61-5
    C14 Glucosyl(β) ceramide (d18:1/14:0) is a β-Glucosyl ceramide.
    C14 Glucosyl(ß) ceramide (d18:1/14:0)
  • HY-N15952
    MS 1 96552-95-3 98%
    MS 1 (Momordica saponin I) is a vaccine adjuvant found in the seeds of perennial Momordica cochinchinensis Spreng.
    MS 1
  • HY-N16009
    α-Rhamnosyl FP20 sodium 3056013-95-4 98%
    α-Rhamnosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Rhamnosyl FP20 sodium
  • HY-N16013
    FP-18 disodium 2936622-27-2 98%
    FP-18 disodium, a TLR-4 agonist, is a vaccine adjuvant.
    FP-18 disodium
  • HY-N16020
    α-Glucosyl FP20 sodium 3056013-97-6 98%
    α-Glucosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Glucosyl FP20 sodium
  • HY-N16021
    4A-MPLA ammonium 2260669-09-6 98%
    4A-MPLA (ammonium) can be used as an adjuvant in vaccine. 4A-MPLA (ammonium) induces tissue-specific immune response. 4A-MPLA (ammonium) can enhance resistance against endotoxin induced effects in host and decrease cytokine production during infection.
    4A-MPLA ammonium
  • HY-N16024
    FP-20 sodium 3056013-47-6
    FP-20 sodium, a selective TLR4 agonist, is a vaccine adjuvant. FP-20 sodium induces MAPK- and NLRP3-dependent inflammasome activation. FP20 shows no toxicity in mouse vaccination experiments with OVA antigen and induces IgG production.
    FP-20 sodium
  • HY-N16034
    MS 2 96552-96-4 98%
    MS 2 (Momordica saponin II) is a vaccine adjuvant found in the seeds of perennial Momordica cochinchinensis Spreng.
    MS 2
  • HY-N16066
    Candidusin A 81474-59-1 98%
    Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a KD of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells). Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research.
    Candidusin A
  • HY-N16067
    Penipanoid C 1442381-95-4
    Penipanoid C (Compound 9) is a BRD4 inhibitor. Penipanoid C can be isolated from marine sediment-derived fungus Penicillium paneum SD-44. Penipanoid C has anti-inflammatory activity and cytotoxic activity against the SMMC-7721 cells. Penipanoid C can be used for inflammatory diseases research.
    Penipanoid C
  • HY-N16129
    Diplacone 73676-38-7
    Diplacone (DP) is a geranylated flavanone. Diplacone can be isolated from the unripe fruits of Paulownia tomentosa. Diplacone has anti-inflammatory, antiradical, cytoprotective, antibacterial and anticancer activities. Diplacone induces ferroptosis-mediated cell death by increasing mitochondrial Ca2+ Influx, ROS production and mitochondrial permeability transition. Diplacone significantly inhibits AChE and BChE activity with IC50s of 7.2  μM and 1.4 μM for hAChE and BChE, respectively. Diplacone can be used for chronic inflammatory diseases like inflammatory bowel diseases (IBD), cancers like lung cancer and Alzheimer’s disease research.
    Diplacone
  • HY-N16144
    Osmanthuside H 149155-70-4
    Osmanthuside H (Compound 1), a phenylethanoid glycoside (PhG), is a alcohol dehydrogenase (ADH) inhibitor with an IC50 of 175.4 μg/mL. Osmanthuside H can be isolated from the leaves of persimmon Diospyros kaki. Osmanthuside H has anti-inflammatory and neuroprotective activities.
    Osmanthuside H
  • HY-N16172
    Sanggenon B 81381-67-1
    Sanggenon B (Sanggenone B) is a compound that can be extracted from mulberry trees and has an inhibitory effect on NO production in RAW264.7 cells stimulated by LPS (HY-D1056). Sanggenon B has anti-inflammatory activity.
    Sanggenon B
  • HY-N16231
    3A-MPLA ammonium 1699735-80-2
    3A-MPLA ammonium, a monophosphoryl rri-acyl lipid A, is a TLR-4 agonist.
    3A-MPLA ammonium
  • HY-N16301
    Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium 98%
    Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium, a lipid, is an adjuvant. Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium has immunostimulatory properties.
    Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium
  • HY-N16329
    Lipid A (14:0(5)-iso15:0(1)) diammonium 3091879-53-4
    Lipid A (14:0(5)-iso15:0(1)) diammonium, a lipid, is an adjuvant. Lipid A (14:0(5)-iso15:0(1)) diammonium has immunostimulatory properties.
    Lipid A (14:0(5)-iso15:0(1)) diammonium
Cat. No. Product Name / Synonyms Application Reactivity