2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-136355S
    Picoxystrobin-d3 98%
    Picoxystrobin-d3 is the deuterium labeled Picoxystrobin (HY-136355). Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
    Picoxystrobin-d3
  • HY-136438R
    Toltrazuril sulfoxide (Standard) 69004-15-5
    Toltrazuril sulfoxide (Standard) is the analytical standard of Toltrazuril sulfoxide. This product is intended for research and analytical applications. Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
    Toltrazuril sulfoxide (Standard)
  • HY-13653S1
    (-)-Epigallocatechin Gallate-d4 98%
    (-)-Epigallocatechin Gallate-d4 (EGCG-d4) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.
    (-)-Epigallocatechin Gallate-d4
  • HY-136540S
    Resolvin D3-d5 98%
    Resolvin D3-d5 is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation.
    Resolvin D3-d5
  • HY-136587R
    Oxomemazine (Standard) 3689-50-7
    Oxomemazine (Standard) is the analytical standard of Oxomemazine (HY-136587). This product is intended for research and analytical applications. Oxomemazine is a phenothiazine-based histamine H1-receptor blocker. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites. Oxomemazine is an antihistamine and anticholinergic agent used for the study of cough treatment. Oxomemazine is protective against anaphylactic microshock in guinea pigs.
    Oxomemazine (Standard)
  • HY-136788A
    ALK4290 dihydrochloride 1372127-19-9 98%
    ALK4290 dihydrochloride (AKST4290 dihydrochlorid) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism.
    ALK4290 dihydrochloride
  • HY-137553A
    β-Aminoarteether maleate 133162-25-1 98%
    β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases.
    β-Aminoarteether maleate
  • HY-137561A
    Bexotegrast hydrochloride 2775365-40-5 98%
    Bexotegrast hydrochloride (PLN-74809 hydrochloride) is a small molecule dual selective inhibitor with activity targeting αVβ1 and αVβ6. Bexotegrast hydrochloride is used for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). Bexotegrast hydrochloride inhibits the activation of TGF-β1 by blocking the function of these integrins, thereby preventing the growth of fibrous tissue in the lungs and bile ducts.
    Bexotegrast hydrochloride
  • HY-137640A
    Sp-8-Br-cAMPS sodium 1573115-90-8 98%
    Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve.
    Sp-8-Br-cAMPS sodium
  • HY-137640B
    Rp-8-Br-cAMPS 129735-00-8 98%
    Rp-8-Br-cAMPS is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS also inhibits insulin secretion.
    Rp-8-Br-cAMPS
  • HY-137640C
    Rp-8-Br-cAMPS sodium 925456-59-3 98%
    Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS sodium occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS sodium can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS sodium also inhibits insulin secretion.
    Rp-8-Br-cAMPS sodium
  • HY-138110R
    Toladryl (Standard) 19804-27-4
    Toladryl (Standard) is the analytical standard of Toladryl. This product is intended for research and analytical applications. Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases.
    Toladryl (Standard)
  • HY-138678B
    (S,R,R)-VH032 2489876-59-5 98%
    (S,R,R)-VH032 is a VHL ligand. (S,R,R)-VH032 can be used for synthesis of PROTAC NCOA4 degrader-1 (HY-163897).
    (S,R,R)-VH032
  • HY-139021A
    ACAT-IN-4 hydrochloride 199984-46-8 98%
    ACAT-IN-4 hydrochloride (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 hydrochloride inhibits NF-κB mediated transcription.
    ACAT-IN-4 hydrochloride
  • HY-139027A
    ACAT-IN-10 dihydrochloride 199983-77-2 98%
    ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription.
    ACAT-IN-10 dihydrochloride
  • HY-139553A
    (R)-Zunsemetinib 1640282-44-5
    (R)-Zunsemetinib is the isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases.
    (R)-Zunsemetinib
  • HY-142686A
    SGK1-IN-3 hydrochloride
    SGK1-IN-3 hydrochloride (compound 3a) is a potent SGK1 inhibitor with an IC50 of <1 μM. SGK1-IN-3 hydrochloride has the potential for the research of osteoarthritis.
    SGK1-IN-3 hydrochloride
  • HY-14300AS
    Vilanterol-d4 trifenatate 2021249-10-3 98%
    Vilanterol-d4 (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.
    Vilanterol-d4 trifenatate
  • HY-143423A
    (S)-MALT1-IN-5 2434602-25-0 98%
    (S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1).
    (S)-MALT1-IN-5
  • HY-14397AR
    Indomethacin sodium hydrate (Standard) 74252-25-8
    Dimethenamide-P (Standard) is the analytical standard of Dimethenamide-P. This product is intended for research and analytical applications. Dimethenamide-P is an amide herbicide effective for the pre-emergence management of annual grasses, small-seeded broadleaf weeds, and sedges in ornamental plants, functioning by inhibiting the synthesis of long-chain fatty acids.
    Indomethacin sodium hydrate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity