2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112142A
    (Rac)-AB-423 422547-55-5 98%
    (Rac)-AB-423 (DVR-23) is an anti-HBV candidate compound with promising anti-HBV activity. (Rac)-AB-423 showed no induction of CYP1A2, CYP3A4, or CYP2B6 enzyme activity at high concentrations. (Rac)-AB-423 exhibited desirable pharmacokinetic properties, enabling good systemic exposure and high oral bioavailability. (Rac)-AB-423 achieved more than 2 log viral load reduction in the hydrodynamic injection (HDI) HBV mouse model.
    (Rac)-AB-423
  • HY-112149A
    (E/Z)-ZL0420 2229039-45-4 98%
    (E/Z)-ZL0420 is a racemic compound of (Z)-ZL0420 and (E)-ZL0420 isomers. (E)-ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2.
    (E/Z)-ZL0420
  • HY-112167B
    GDC0575 hydrochloride 1196504-54-7 98%
    GDC0575 (ARRY-575) hydrochloride is a highly-selective and orally active Chk1 (IC50=1.2 nM) inhibitor. GDC0575 (ARRY-575) hydrochloride can be used for colitis-associated cancer (CAC) and colitis research.
    GDC0575 hydrochloride
  • HY-112175R
    N-Acetylhistamine (Standard) 673-49-4
    Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.
    N-Acetylhistamine (Standard)
  • HY-112390B
    Syk Inhibitor II dihydrochloride dihydrate 1965323-05-0 98%
    Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect.
    Syk Inhibitor II dihydrochloride dihydrate
  • HY-112390C
    Syk Inhibitor II hydrochloride 2490508-82-0 98%
    Syk Inhibitor II hydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II hydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II hydrochloride shows less potent against other kinases and has anti-allergic effect.
    Syk Inhibitor II hydrochloride
  • HY-112482A
    ABT-702 hydrochloride 2624336-92-9 98%
    ABT-702 hydrochloride is a potent inhibitor of adenosine kinase with an IC50 of 1.7 nM.
    ABT-702 hydrochloride
  • HY-112532A
    REV 5901 hydrochloride 92532-23-5 98%
    REV 5901 hydrochloride is a competitive and orally active antagonist of leukotriene receptor, with a Ki of 0.7 μM. REV 5901 hydrochloride is also a 5-lipoxygenase inhibitor. REV 5901 hydrochloride can be used for the research of asthma in which leukotriene release be involved. REV 5901 hydrochloride can be used for the study of colon carcinoma.
    REV 5901 hydrochloride
  • HY-112675R
    4-Octyl itaconate (Standard) 3133-16-2
    4-Octyl itaconate (Standard) is the analytical standard of 4-Octyl itaconate. This product is intended for research and analytical applications. 4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1[1].
    4-Octyl itaconate (Standard)
  • HY-113066B
    Guanosine 5'-diphosphate ditromethamine 103192-39-8 98%
    Guanosine 5'-diphosphate ditromethamine is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate ditromethamine is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate ditromethamine can be used in the research of inflammation, such as anemia of inflammation (AI).
    Guanosine 5'-diphosphate ditromethamine
  • HY-113074R
    Glycolithocholic acid 3-sulfate (Standard) 15324-64-8
    Propyzamide (Standard) is the analytical standard of Propyzamide. This product is intended for research and analytical applications. Propyzamide is a anti-microtubule herbicide.
    Glycolithocholic acid 3-sulfate (Standard)
  • HY-113116S
    Sphinganine 1-phosphate-d7 2315262-23-6 98%
    Sphinganine 1-phosphate-d7 is deuterium labeled Sphinganine 1-phosphate. Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiologic
    Sphinganine 1-phosphate-d7
  • HY-113133R
    Kojibiose (Standard) 2140-29-6
    Kojibiose (Standard) is the analytical standard of Kojibiose. This product is intended for research and analytical applications. Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo[1][2].
    Kojibiose (Standard)
  • HY-113212R
    Ursocholic acid (Standard) 2955-27-3
    Ursocholic acid (Standard) is the analytical standard of Ursocholic acid. This product is intended for research and analytical applications. Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis[1][2][3][4][5].
    Ursocholic acid (Standard)
  • HY-113212S
    Ursocholic acid-d4 98%
    Ursocholic acid-d4 is deuterium labeled Ursocholic acid. Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis.
    Ursocholic acid-d4
  • HY-113224R
    Desmosterol (Standard) 313-04-2
    Desmosterol (Standard) is the analytical standard of Desmosterol. This product is intended for research and analytical applications. Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3].
    Desmosterol (Standard)
  • HY-113298R
    Citraconic acid (Standard) 498-23-7
    Citraconic acid (Methylmaleic acid) (Standard) is the analytical standard of Citraconic acid (HY-113298). This product is intended for research and analytical applications. Citraconic acid is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052).
    Citraconic acid (Standard)
  • HY-113332R
    Myristoleic acid (Standard) 544-64-9
    Myristoleic acid (Standard) is the analytical standard of Myristoleic acid. This product is intended for research and analytical applications. Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells[1].
    Myristoleic acid (Standard)
  • HY-113334R
    Turanose (Standard) 547-25-1
    Turanose (Standard) is the analytical standard of Turanose. This product is intended for research and analytical applications. Turanose is an isomer of Sucrose that naturally exists in honey. Turanose has anti-inflammatory and regulates adipogenesis effect. Turanose has potential for obesity and related chronic diseases research[1][2].
    Turanose (Standard)
  • HY-113357S
    m-Coumaric acid-13C3 1261170-79-9 98%
    m-Coumaric acid-13C3 is the 13C-labeled m-Coumaric acid. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.
    m-Coumaric acid-13C3
Cat. No. Product Name / Synonyms Application Reactivity