2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-158295
    IAA/BSA 98%
    IAA/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    IAA/BSA
  • HY-158296
    Tetracycline/OVA 98%
    Tetracycline/OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Tetracycline/OVA
  • HY-158297
    Histamine/OVA 98%
    Histamine/OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Histamine/OVA
  • HY-158298
    Penicillin/BSA 98%
    Penicillin/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Penicillin/BSA
  • HY-158299
    Periplogenin/BSA 98%
    Periplogenin/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Periplogenin/BSA
  • HY-158338
    ABHD antagonist 1 3034510-10-3 98%
    ABHD antagonist 1 possesses ABHD6 (α/β-Hydrolase domain containing 6) inhibitory activity, involving the regulation of biochemical pathways involved in ABHD6, thereby affecting cell function and inflammatory response. ABHD antagonist 1 can be used in pain, neuropathic diseases, inflammatory diseases. Autoimmune diseases, metabolic diseases, and cancer research.
    ABHD antagonist 1
  • HY-158347
    SARS-CoV-2 Mpro-IN-15 98%
    SARS-CoV-2 Mpro-IN-15 (8E) is a SARS-CoV-2 Mpro inhibitor, with an IC50 of  0.606 µM.
    SARS-CoV-2 Mpro-IN-15
  • HY-158363
    CSF1R-IN-25 2070864-23-0 98%
    CSF1R-IN-25 (compound 36) is an orally effective CSF1R inhibitor. CSF1R-IN-25 can be used to study cancer, inflammation, and neurodegeneration.
    CSF1R-IN-25
  • HY-158374
    BIO-8169 2792153-06-9 98%
    BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7.
    BIO-8169
  • HY-158402
    Anti-inflammatory agent 84 98%
    Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell.
    Anti-inflammatory agent 84
  • HY-158434
    IRAK1-IN-1 98%
    IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC50 values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS (HY-D1056)-induced acute lung injury (ALI) and DSS(HY-116282C)-induced colitis in mice.
    IRAK1-IN-1
  • HY-158550
    13(R),14(R)-epoxy Fluprostenol isopropyl ester 2557329-36-7 98%
    13(R),14(R)-epoxy Fluprostenol isopropyl ester is a Prostaglandin derivative.
    13(R),14(R)-epoxy Fluprostenol isopropyl ester
  • HY-158688
    PI3Kδ-IN-21 98%
    PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC50 of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model.
    PI3Kδ-IN-21
  • HY-158694
    TLR7 agonist 20 3029695-00-6 98%
    TLR7 agonist 20 (compound 23) is an imidazoquinoline analogue. TLR7 agonist 20 is a potent TLR7 specific agonist, with an EC50 value of 0.23 μM for hTLR7. TLR7 agonist 20 shows strong adjuvant activity on spike antibody levels which induces a strong T helper 1 (Th1) response with increase in IgG2b and IgG2c, in addition to IgG1.
    TLR7 agonist 20
  • HY-158732
    MAO-B-IN-33 2286257-25-6 98%
    MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC50 of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP (HY-15608)-induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research.
    MAO-B-IN-33
  • HY-158758
    PROTAC IRAK4 degrader-10 3033829-95-4 98%
    PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand).
    PROTAC IRAK4 degrader-10
  • HY-158822
    IMT504 1075758-80-3
    IMT504, a non-CpG 24-mer oligodeoxynucleotide, is an immunomodulatory oligonucleotide currently being investigated as a rabies vaccine. IMT504 has been previously proven to be effective in animal models of vaccine potency, chronic lymphocytic leukemia, tissue regeneration, and sepsis.
    IMT504
  • HY-158881
    DDG 2350271-86-0 98%
    DDG is a type of detergent that can dissolve membrane proteins (MPs) in bacterial membranes, insect cells, and Madin Darby Canine Kidney (MDCK) cells.
    DDG
  • HY-159004
    Se-DOPE 98%
    Se-DOPE is a phospholipid molecule with selenium. Se-DOPE can be used to synthesize the bifunctional Janus liposozyme. Se-DOPE promotes the production of ROS with induction of lights, scavenges the ROS with the presence of glutathione. Se-DOPE regulates redox and immune homeostasis in infected diabetic wounds.
    Se-DOPE
  • HY-159060
    Coriolus Versicolor Extract 98%
    Coriolus Versicolor Extract is a biological response modifier (BRM) with anti-cancer and anti-migratory properties. Coriolus Versicolor Extract can also inhibit the expression of tumorigenic factors associated with inflammation and can be used in cancer research.
    Coriolus Versicolor Extract
Cat. No. Product Name / Synonyms Application Reactivity