2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130625
    PD-1/PD-L1-IN 6 2393983-76-9 98%
    PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model.
    PD-1/PD-L1-IN 6
  • HY-13067G
    Celastrol (GMP) 34157-83-0
    Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH.
    Celastrol (GMP)
  • HY-130691
    MitoP bromide 74597-01-6 98%
    MitoP bromide is the reaction product of MitoB with H2O2. A high MitoP/MitoB ratio indicates that the mitochondria have a high average level of H2O2.
    MitoP bromide
  • HY-130762
    Cinnamic acid sodium 538-42-1 98%
    Cinnamic acid sodium is a orally active naturally occurring aromatic fatty acid of low toxicity. Cinnamic acid sodium shows neuroprotective and anti-inflammatory effects.
    Cinnamic acid sodium
  • HY-131103
    Phenylethanolamine A 1346746-81-3 98%
    Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A
  • HY-131152
    Leucinostatin (mixture of A&B) 98%
    Leucinostatin (mixture of A&B), the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus, are antibiotics.
    Leucinostatin (mixture of A&B)
  • HY-131184
    N-Boc-piperazine-C3-COOH 959053-53-3
    N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    N-Boc-piperazine-C3-COOH
  • HY-131220
    aPKC-IN-1 15854-12-3 98%
    aPKC-IN-1 (compound 1) is an atypical protein kinase C (aPKCζ) inhibitor. aPKC-IN-1 can be used for the study of a host of diseases involving increased vascular permeability and inflammation.
    aPKC-IN-1
  • HY-131260
    Ibuprofen Impurity K 43153-07-7 98%
    Ibuprofen Impurity K is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    Ibuprofen Impurity K
  • HY-131261
    Ibuprofen alcohol 36039-36-8 98%
    Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).
    Ibuprofen alcohol
  • HY-131265
    Mesalamine impurity P 887256-40-8 98%
    Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
    Mesalamine impurity P
  • HY-131416
    DD-3305 55690-47-6 98%
    DD-3305 is an anti-inflammatory agent with comparable anti-inflammatory activity to the known anti-inflammatory agent indomethacin (HY-14397). In a carrageenin-induced rat inflammation model, DD-3305 was effective in inhibiting chronic and acute inflammation as well as induced allergies..
    DD-3305
  • HY-131471
    Zafirlukast metabolite M1 219583-10-5 98%
    Zafirlukast metabolite M1 (compound 15) is an inhibitor of allergic lung diseases such as asthma and can antagonize the activity of leukotrienes.
    Zafirlukast metabolite M1
  • HY-131607
    Carbovir triphosphate 129941-14-6 98%
    Carbovir triphosphate (CBV-TP) is a phosphorylated metabolite. Carbovir triphosphate can be used for the research of human immunodeficiency virus (HIV).
    Carbovir triphosphate
  • HY-131616
    Ethyl α-eleostearate 42021-86-3 98%
    Ethyl α-eleostearate is isolated from the ethanolic extract of Pseudo-nitzschia australis (PAEE). The PAEE of Pseudomonas australis has anti-neuroinflammatory effects, inhibiting intracellular ROS as well as pro-inflammatory mediators and cytokines.
    Ethyl α-eleostearate
  • HY-131675
    CH-100 51346-20-4 98%
    CH-100 is an immunomodulatory agent targeting T-cell activation and inflammatory mediator production. CH-100 demonstrates anti-inflammatory and hepatoprotective effects by reducing TNF-α secretion, suppressing CD4+ T-cell proliferation, and lowering endotoxin levels in alcohol-fed rats. CH-100 is promising for research of alcoholic liver disease and T-cell-mediated hepatitis.
    CH-100
  • HY-131803
    3'-Azido-3'-deoxyguanosine 98870-11-2 98%
    Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model. 3'-Azido-3'-deoxyguanosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3'-Azido-3'-deoxyguanosine
  • HY-131895
    5,6-Dehydroarachidonic acid 58688-54-3 98%
    5,6-Dehydroarachidonic acid is a 5-lipoxygenase (Lipoxygenase) inhibitor that inhibits the biosynthesis of leukotrienes. However, 5,6-Dehydroarachidonic acid had no effect on vascular cell proliferation.
    5,6-Dehydroarachidonic acid
  • HY-131912
    Thalidomide-NH-PEG8-Ts 2488761-07-3
    Thalidomide-NH-PEG8-Ts is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 8-unit PEG linker used in PROTAC technology, such as IDO1 PROTAC degrader (HY-131911).
    Thalidomide-NH-PEG8-Ts
  • HY-131992
    N-Acetylpsychosine 35823-61-1 98%
    N-Acetylpsychosine (C2 Galactosylceramide (d18:1/2:0)), α-galactosylated C2-ceramide, has immunostimulatory activity. N-Acetylpsychosine can be a useful tool to investigate the mechanism of apoptosis and the immune reponses induced by dendritic cells (DCs).
    N-Acetylpsychosine
Cat. No. Product Name / Synonyms Application Reactivity