2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-156398
    Anti-inflammatory agent 60 98%
    Anti-inflammatory agent 60(compound 21) inhibitsnitric oxide production, with anIC50value of 12.95 μM.Anti-inflammatory agent 60reducesiNOS,phosphorylated p65, andβ-cateninexpression in a concentration-dependent manner.
    Anti-inflammatory agent 60
  • HY-156408
    Spns2-IN-1 98%
    Spns2-IN-1 is a potent inhibitor of Spns2-dependent S1P transport (Spns2), with IC50 of 1.4±0.3 μM that plays an important role in immune response.
    Spns2-IN-1
  • HY-156425
    NOX2-IN-2 2648709-79-7 98%
    NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells.
    NOX2-IN-2
  • HY-156458
    SR-29065 98%
    SR-29065 is a selective REV-ERBα agonist, can be used for autoimmune disorders research.
    SR-29065
  • HY-156469
    NLRP3-IN-22 1193329-98-4 98%
    NLRP3-IN-22 (Compound II-4) is a NLRP3 inhibitor (inhibition rate: 67% at 10 μM)
    NLRP3-IN-22
  • HY-156534
    5-HT2A&5-HT2C agonist-1 1640-02-4 98%
    5-HT2A&5-HT2C agonist-1 (Example 2) is a 5-HT2A & 5-HT2C agonist, with IC50s of 196 nM and 0.9 nM respectively. 5-HT2A&5-HT2C agonist-1 can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders.
    5-HT2A&5-HT2C agonist-1
  • HY-156535
    JAK kinase-IN-1 2698389-43-2 98%
    JAK kinase-IN-1 (Example 1) is a JAK inhibitor. JAK kinase-IN-1 inhibits TYK2, JAK1, JAK2 and JAK3 with IC50 values of 4.2 nM, 32 nM, 27 nM, 3473 nM respectively.
    JAK kinase-IN-1
  • HY-156536
    RXFP1 receptor agonist-1 2924619-64-5 98%
    RXFP1 receptor agonist-1 (Example 2 peak2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-1 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 300 nM.
    RXFP1 receptor agonist-1
  • HY-156537
    RXFP1 receptor agonist-2 2924460-54-6 98%
    RXFP1 receptor agonist-2 (Example 124) is a RXFP1 receptor agonist. RXFP1 receptor agonist-2 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1 nM.
    RXFP1 receptor agonist-2
  • HY-156538
    RXFP1 receptor agonist-3 2924767-53-1 98%
    RXFP1 receptor agonist-3 (Example 223) is a RXFP1 receptor agonist. RXFP1 receptor agonist-3 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 2 nM.
    RXFP1 receptor agonist-3
  • HY-156539
    RXFP1 receptor agonist-4 2941376-76-5 98%
    RXFP1 receptor agonist-4 (Example 268) is a RXFP1 receptor agonist. RXFP1 receptor agonist-4 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 4.9 nM.
    RXFP1 receptor agonist-4
  • HY-156540
    RXFP1 receptor agonist-5 2941385-36-8 98%
    RXFP1 receptor agonist-5 (Example 98) is a RXFP1 receptor agonist. RXFP1 receptor agonist-5 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1.3 nM.
    RXFP1 receptor agonist-5
  • HY-156541
    RXFP1 receptor agonist-6 2941346-85-4 98%
    RXFP1 receptor agonist-6 (Example 7) is a RXFP1 receptor agonist. RXFP1 receptor agonist-6 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 12 nM.
    RXFP1 receptor agonist-6
  • HY-156542
    RXFP1 receptor agonist-7 2941484-13-3 98%
    RXFP1 receptor agonist-7 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-7 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 4.2 nM.
    RXFP1 receptor agonist-7
  • HY-156543
    RXFP1 receptor agonist-8 2941271-76-5 98%
    RXFP1 receptor agonist-8 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-8 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1.8 nM.
    RXFP1 receptor agonist-8
  • HY-156550
    ROCK-IN-8 1621103-79-4 98%
    ROCK-IN-8 (Example 4) is a ROCK inhibitor, with an IC50 value less than 100 nM. ROCK-IN-8 has anti-inflammatory activity. ROCK-IN-8 can be used for research of respiratory and gastro-intestinal diseases.
    ROCK-IN-8
  • HY-156553
    BTK-IN-27 1841502-36-0 98%
    BTK-IN-27 (example 8) is a BTK inhibitor (IC50: 0.2 nM). BTK-IN-27 shows anti-proliferative activity in TMD8 cells (IC50: < 5 nM). BTK-IN-27 can be used for research of cancer, lymphoma, leukemia and immunological diseases.
    BTK-IN-27
  • HY-156556
    c-Fms-IN-14 1898210-99-5 98%
    c-Fms-IN-14 (Example 76) is a c-Fms inhibitor with an IC50 value of 4 nM. c-Fms-IN-14 can be used for research of cancer and autoimmune diseases.
    c-Fms-IN-14
  • HY-156565
    S1P1 agonist 6 2433782-42-2 98%
    S1P1 agonist 6 (Compound I) is a S1P1 agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 can be used as an immunosuppressive agent in the study of various autoimmune diseases research.
    S1P1 agonist 6
  • HY-156570
    DGKα-IN-3 2648418-86-2 98%
    DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
    DGKα-IN-3
Cat. No. Product Name / Synonyms Application Reactivity