2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116836
    p38α inhibitor 7 668981-02-0 98%
    p38α inhibitor 7 (compound 1) is an effective p38α inhibitor with oral efficacy and generally favorable pharmacokinetic properties.
    p38α inhibitor 7
  • HY-116866
    Sclerotiorin 549-23-5 98%
    Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
    Sclerotiorin
  • HY-116885
    Thunalbene 220862-05-5 98%
    Thunalbene is a stilbene derivative isolated from Thunia alba. Thunalbene has a weak inhibitory effect on nitric oxide production and is not cytotoxic.
    Thunalbene
  • HY-116890
    CRTh2 antagonist 4 916046-55-4 98%
    CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases.
    CRTh2 antagonist 4
  • HY-116933
    Murrayanol 144525-81-5 98%
    Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and topoisomerase II (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial.
    Murrayanol
  • HY-116947
    COX-2-IN-5 416901-58-1 98%
    COX-2-IN-5 (compound 11a) is a potent COX-2 inhibitor with an IC50 value of 0.65 µM. COX-2-IN-5 has the potential for the research of inflammation.
    COX-2-IN-5
  • HY-117008
    CAY10589 1077626-52-8 98%
    CAY10589 is an inhibitor of mPGES-1, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs.
    CAY10589
  • HY-117024
    Abediterol napadisylate 1044516-17-7 98%
    Abediterol napadisylate is an inhaled long-acting β2-adrenoceptor agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD).
    Abediterol napadisylate
  • HY-117091
    DDD-028 1538586-09-2 98%
    DDD-028 is a potent non-opioid, non-cannabinoid analgesic which attenuates neuropathic and inflammatory pain without the possible side effects or abuse potential associated with opioid or cannabinoid activities. DDD-028 can be utilized in analgesic research.
    DDD-028
  • HY-117151
    A-315675 335679-69-1 98%
    A-315675 is a potent highly potent inhibitor of A and B strain influenza virus neuraminidases inhibitor.
    A-315675
  • HY-117182
    LG190178 233268-81-0 98%
    LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer.
    LG190178
  • HY-117256
    Gabazine free base 105538-73-6 98%
    Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of 0.2 μM for GABA receptor.
    Gabazine free base
  • HY-117317
    BLX-2477 1080008-87-2 98%
    BLX-2477 is a potent and selective 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 99 nM. BLX-2477 can inhibit the generation of inflammatory lipid mediators such as 15-hydroxy-eicosatetraenoic acid (15-HETE). BLX-2477 can be used for the research of inflammation and immunology.
    BLX-2477
  • HY-117378
    N-5984 220475-76-3 98%
    N-5984 (KRP-204) is a potent and selective agonist of β3-adrenergic receptor. N-5984 has the potential for developing as one of the clinically effective drugs for obesity and diabetes mellitus.
    N-5984
  • HY-117461
    Y 25510 145194-32-7 98%
    Y 25510 is a 1H-pyrazolo[3,4-b]pyridine-1-acetic acid derivative. Y 25510 stimulates production of cytokines (IL-1α, IL-1β, IL-10 and IL-6).
    Y 25510
  • HY-117463
    Dexamethasone beloxil 150587-07-8 98%
    Dexamethasone beloxil (AL-2512) is a novel corticosteroid with anti-inflammatory and ocular hypertensive effects .
    Dexamethasone beloxil
  • HY-117478
    FE-999024 168825-65-8 98%
    FE-999024 (CH-2856) is a specific tissue kallikrein inhibitor. FE-999024 can inhibit cancer cells invasion with a maximum of 39%. FE-999024 can reduce eosinophilia in a model of allergic inflammation. FE-999024 can be used for the researches of cancer, inflammation and immunology.
    FE-999024
  • HY-117485
    CBR-096-4 1776931-05-5 98%
    CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis.
    CBR-096-4
  • HY-117500
    Aplysamine-1 159026-30-9 98%
    Aplysamine-1 acts as an antagonist for the histamine H3 receptor.
    Aplysamine-1
  • HY-117501
    Dexchlorpheniramine 25523-97-1 98%
    Dexchlorpheniramine is an potent and blood-brain barrier (BBB) penetrant histamine 1 (H1) receptor antagonist with anticholinergic properties. Dexchlorpheniramine can be used for researching allergies.
    Dexchlorpheniramine
Cat. No. Product Name / Synonyms Application Reactivity