2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-106027
    Romazarit 109543-76-2 98%
    Romazarit (RO 31-3948) is an anti-inflammatory agent with antirheumatic effect. Romazarit exhibits PPARα agonist activity. Romazarit (30 mg/kg) inhibits the development of hindpaw inflammation in an adjuvant arthritis model.
    Romazarit
  • HY-106050
    Tilomisole 58433-11-7 98%
    Tilomisole (Wy 18251) is a benzimidazothiazole experimental agent with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation.
    Tilomisole
  • HY-106054
    Nocloprost 79360-43-3 98%
    Nocloprost, a prostaglandin E2 (PGE2) analog, is an orally active EP1- and EP3-receptor agonist. Nocloprost inhibits evoked [3H]ACh release. Nocloprost has gastroprotective and ulcer-healing properties. Nocloprost accelerates the healing of chronic gastric ulcerations and enhances mucosal growth in rats.
    Nocloprost
  • HY-106055
    Murabutide 74817-61-1 98%
    Murabutide is a safe synthetic immunomodulator. Murabutide can reduce CD4 and CCR5 receptor expression and secrete high levels of beta-chemokines. Murabutide enhances nonspecific resistance against viral infections. Murabutide did not affect virus entry, reverse transcriptase activity or early proviral DNA formation in the cytoplasm of infected cells.
    Murabutide
  • HY-106076
    REV 2871 80263-73-6 98%
    REV 2871 (Eclazolast; CHBZ) is a potent and oral activity antiallergic agent. REV 2871 also is an irreversibility histamine release (HR) inhibitor.
    REV 2871
  • HY-106078
    Oxmetidine 72830-39-8 98%
    Oxmetidine (SKF 92994) is an orally active H2-receptor antagonist, and is an anti-ulcer agent.
    Oxmetidine
  • HY-106093
    Eltenac 72895-88-6 98%
    Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood.
    Eltenac
  • HY-106137
    Tofimilast 185954-27-2 98%
    Tofimilast is an inhibitor of Phosphodiesterase 4 (PDE4) with an IC50 of 0.14 μM. Tofimilast exerts its anti-inflammatory effects by inhibiting the activity of PDE4, thereby increasing intracellular levels of cAMP.
    Tofimilast
  • HY-106156
    Allotrap 07 151232-75-6 98%
    Allotrap 07 is a synthetic peptide composed of residues 75-84 of HLA-B7, a class I MHC molecule. Allotrap 07 combined with Cyclosporin A (HY-B0579) induces donor-specific tolerance in rat cardiac allografts, significantly prolonging graft survival.
    Allotrap 07
  • HY-106165
    HMR-4011A 202415-99-4 98%
    HMR-4011A (IPL 576092) is an orally active, chemically modified version of Contignasterol. HMR-4011A can be isolated from sponge Petrosia contignata. HMR-4011A reduces inflammation. HMR-4011A can be used in the research of asthma.
    HMR-4011A
  • HY-106187
    MART-1 (27-35) (human) 156251-11-5 98%
    MART-1 (27-35) (human) is an immunogenic epitope recognized by HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TIL).
    MART-1 (27-35) (human)
  • HY-106215
    Etiprednol dicloacetate 199331-40-3 98%
    Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma.
    Etiprednol dicloacetate
  • HY-106216
    Tiprelestat 820211-82-3 98%
    Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease.
    Tiprelestat
  • HY-106253
    Efipladib 381683-94-9 98%
    Efipladib is a potent, selective and orally active cPLA2α inhibitor with an IC50 of 0.04 μM and a Kd of 0.067 μM.
    Efipladib
  • HY-106293
    ICI-200880 105080-50-0 98%
    ICI-200880 is a potent, selective and reversible human neutrophil elastase (HNE) inhibitor. ICI-200880 is promising for research of inflammatory lung diseases related to neutrophil elastase, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).
    ICI-200880
  • HY-106325
    AA 2379 103446-98-6 98%
    AA 2379 is an orally active antirheumatic agent. AA 2379 has antiinflammatory, antipyretic activities and reduces pain sensation.
    AA 2379
  • HY-106345
    ILS-920 892494-07-4 98%
    ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12.
    ILS-920
  • HY-106347
    Itriglumide 201605-51-8 98%
    Itriglumide (CR 2945) is an anthranilic acid derivative. Itriglumide is a potent and selective CCKB receptor antagonist, with an IC50 of 2.3 nM. Itriglumide antagonizes the response to gastrin in a dose-dependent manner with an IC50 of 5.9 nM. Itriglumide shows antisecretory and antiulcer activity.
    Itriglumide
  • HY-106359
    Delmitide 287096-87-1 98%
    Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis.
    Delmitide
  • HY-106368
    Dexamethasone cipecilate 132245-57-9 98%
    Dexamethasone cipecilate (NS-126) is a corticosteroid whose local efficacy and durability have been enhanced by the introduction of a lipophilic functional group. Dexamethasone cipecilate can be used as a nasal spray and is applicable in rhinitis research.
    Dexamethasone cipecilate
Cat. No. Product Name / Synonyms Application Reactivity