2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130339
    Teicoplanin A2-4 91032-37-0 98%
    Teicoplanin A2-4 is an antibiotic active against Gram-positive aerobic and anaerobic bacteria.
    Teicoplanin A2-4
  • HY-130365
    Tixocortol pivalate 55560-96-8
    Tixocortol pivalate is a corticosteroid with some anti-inflammatory activity.
    Tixocortol pivalate
  • HY-130392
    Wofapyrin 8066-94-2 98%
    Wofapyrin (Rheumopyrin) is an antipyretic and anti-inflammatory agent, exhibiting notable activity in promoting lesion volume compared to penicillin, while being less effective than OTESOLUT and nearly equivalent to 5% WOFAPYRIN.
    Wofapyrin
  • HY-130440
    Leukotriene F4 83851-42-7 98%
    Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family. Leukotriene F4 induces bronchoconstriction with an ED50 of 16 μg/kg. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase.
    Leukotriene F4
  • HY-130441
    Leukotriene B3 88099-35-8 98%
    Leukotriene B3 is a LTA hydrolase metabolite of LTA3 in the leukotriene biosynthesis pathway. Leukotriene B3 has proinflammatory activity.
    Leukotriene B3
  • HY-130497
    12-Oxo-leukotriene B4 136696-10-1 98%
    12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC50 of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC50 of 170 nM.
    12-Oxo-leukotriene B4
  • HY-130570
    β-Gal-NONOate 357192-77-9 98%
    Beta-gal-nonoate is a β-galactosidase dependent nitric oxide (NO) donor that releases NO once activated by β-galactosidase. β-Gal-NONOate has bactericidal activity and can be used as a bactericide .
    β-Gal-NONOate
  • HY-130607
    IDO1-IN-2 2346614-58-0 98%
    IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.
    IDO1-IN-2
  • HY-130625
    PD-1/PD-L1-IN 6 2393983-76-9 98%
    PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model.
    PD-1/PD-L1-IN 6
  • HY-13067G
    Celastrol (GMP) 34157-83-0
    Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH.
    Celastrol (GMP)
  • HY-130691
    MitoP bromide 74597-01-6 98%
    MitoP bromide is the reaction product of MitoB with H2O2. A high MitoP/MitoB ratio indicates that the mitochondria have a high average level of H2O2.
    MitoP bromide
  • HY-130762
    Cinnamic acid sodium 538-42-1 98%
    Cinnamic acid sodium is a orally active naturally occurring aromatic fatty acid of low toxicity. Cinnamic acid sodium shows neuroprotective and anti-inflammatory effects.
    Cinnamic acid sodium
  • HY-131103
    Phenylethanolamine A 1346746-81-3 98%
    Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A
  • HY-131152
    Leucinostatin (mixture of A&B) 98%
    Leucinostatin (mixture of A&B), the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus, are antibiotics.
    Leucinostatin (mixture of A&B)
  • HY-131184
    N-Boc-piperazine-C3-COOH 959053-53-3
    N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    N-Boc-piperazine-C3-COOH
  • HY-131220
    aPKC-IN-1 15854-12-3 98%
    aPKC-IN-1 (compound 1) is an atypical protein kinase C (aPKCζ) inhibitor. aPKC-IN-1 can be used for the study of a host of diseases involving increased vascular permeability and inflammation.
    aPKC-IN-1
  • HY-131260
    Ibuprofen Impurity K 43153-07-7 98%
    Ibuprofen Impurity K is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    Ibuprofen Impurity K
  • HY-131261
    Ibuprofen alcohol 36039-36-8 98%
    Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).
    Ibuprofen alcohol
  • HY-131265
    Mesalamine impurity P 887256-40-8 98%
    Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
    Mesalamine impurity P
  • HY-131416
    DD-3305 55690-47-6 98%
    DD-3305 is an anti-inflammatory agent with comparable anti-inflammatory activity to the known anti-inflammatory agent indomethacin (HY-14397). In a carrageenin-induced rat inflammation model, DD-3305 was effective in inhibiting chronic and acute inflammation as well as induced allergies..
    DD-3305
Cat. No. Product Name / Synonyms Application Reactivity