2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-123382
    GSK-1482160 (isomer) 1695551-19-9 98%
    GSK-1482160 isomer is the isomer of GSK-1482160. GSK1482160 is a potent P2X7 antagonist with excellent biological activity.
    GSK-1482160 (isomer)
  • HY-123399
    Ro 19-1400 122937-55-7 98%
    Ro 19-1400 is a platelet-activating factor antagonist that directly inhibits immunoglobulin E-dependent mediator release.
    Ro 19-1400
  • HY-123432
    AHR-13268D 130838-11-8 98%
    AHR-13268D is an oral active antiallergic and antihistaminic agent, with bioavailable approximately 88%. AHR-13268D is a potent inhibitor of histamine release from rat peritoneal mast cells, with the IC50 of 0.51 nM.
    AHR-13268D
  • HY-123461
    Sul-121 hydrochloride 1541170-25-5 98%
    Sul-121 hydrochloride is a novel compound with anti-oxidative capacity that effectively inhibits airway inflammation and hyperresponsiveness (AHR) in experimental models of chronic obstructive pulmonary disease (COPD). Sul-121 hydrochloride prevents lipopolysaccharide-induced airway neutrophilia and AHR in a dose-dependent manner. Sul-121 hydrochloride also demonstrates the ability to reduce oxidative stress markers in human airway smooth muscle cells. Sul-121 hydrochloride inhibits nuclear translocation of the NF-κB subunit, p65, thereby diminishing pro-inflammatory cytokine release.
    Sul-121 hydrochloride
  • HY-123490
    Regrelor disodium 676251-22-2 98%
    Regrelor disodium (INS 50589) is a platelet P2Y12 receptor antagonist. Regrelor disodium is a well-tolerated, reversible ADP competitive antagonist. Regrelor disodium inhibits cell proliferation. Regrelor disodium can be used in inflammation-related research.
    Regrelor disodium
  • HY-123493
    P552-02 mesylate 587879-54-7 98%
    P552-02 (552-02) mesylate is a sodium channel blocker that is potentially used for the treatment of cystic fibrosis, exhibiting biological activity that enhances mucociliary clearance in the lungs while minimizing the risk of hyperkalaemia.
    P552-02 mesylate
  • HY-123522
    PAT-048 1359983-15-5 98%
    PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 shows an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. PAT-048 reduces dermal fibrosis in vivo.
    PAT-048
  • HY-123531
    JNJ 10329670 400797-24-2 98%
    JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation.
    JNJ 10329670
  • HY-123550
    Rosenonolactone 508-71-4 98%
    Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein.
    Rosenonolactone
  • HY-12355S
    Siponimod-d11 2104759-32-0 98%
    Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research.
    Siponimod-d11
  • HY-123575
    LY 245769 127345-02-2 98%
    LY 245769, a omega-trifluoro analog, is a leukotriene E4 (LTE4) inhibitor. LY 245769 interfers the omega-oxidation of N-acetyl-LTE4 and leukotriene B4 (LTB4) with IC50s of 4 μM.
    LY 245769
  • HY-12358A
    Tpl2 Kinase Inhibitor 1 hydrochloride 2934185-09-6
    Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers.
    Tpl2 Kinase Inhibitor 1 hydrochloride
  • HY-123606
    GSK484 1652629-23-6 98%
    GSK484 is a PAD4 inhibitor. GSK484 reduces inflammation and joint destruction in CIA mouse models. GSK484 inhibits TNF-α expression and reverses Erastin-induced gut dysbiosis. GSK484 can be used in rheumatoid arthritis (RA) research.
    GSK484
  • HY-123637
    Autotaxin-IN-1 1619971-30-0 98%
    Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
    Autotaxin-IN-1
  • HY-123638
    6-Hydroxykaempferol 3,6,7-tri-O-β-D-glucoside 145134-62-9 98%
    6-hydroxykaempferol 3,6,7-tri-O-β-D-glucoside is a bio-active flavonoid from Carthamus tinctorius with antioxidant capacities in vitro.
    6-Hydroxykaempferol 3,6,7-tri-O-β-D-glucoside
  • HY-123639
    LM-4108 261766-32-9
    LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively.
    LM-4108
  • HY-123642
    BLXA-4-ME 362516-29-8 98%
    BLXA-4-ME is used for gingivitis study.
    BLXA-4-ME
  • HY-123679
    FR168888 168620-46-0 98%
    FR168888 is an inhibitor of Na+/H+ exchange with a Ki value of 6.4 nM.
    FR168888
  • HY-123691
    7-O-Demethyl rapamycin 151519-50-5 98%
    7-O-Demethyl rapamycin, a derivative of Rapamycin (HY-10219), has antifungal activity and immunosuppressant properties. 7-O-Demethyl rapamycin has useful tumor cell growth-inhibiting activity.
    7-O-Demethyl rapamycin
  • HY-123693
    ML358 1158607-44-3 98%
    ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics.
    ML358
Cat. No. Product Name / Synonyms Application Reactivity