2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118795
    SC-22716 262451-89-8 98%
    SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis.
    SC-22716
  • HY-118820
    MB-28767 80558-61-8 98%
    MB-28767 (M&B 28767) is an EP3 receptor agonist.
    MB-28767
  • HY-118912
    BMH-9 457937-39-2 98%
    BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2). BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models.
    BMH-9
  • HY-118915
    FR 106969 50655-20-4 98%
    FR 106969 (A26771E) is a platelet activating factor antagonist with anti-inflammatory activity. FR 106969 can be used to alleviate inflammatory responses. FR 106969 has shown potential inhibitory effects on inflammation-related diseases in studies.
    FR 106969
  • HY-118935
    NGD9002 free base 666256-06-0 98%
    NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension.
    NGD9002 free base
  • HY-118958
    Ablukast 96566-25-5 99.36%
    Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist. Ablukast effectively reduces LTC4- and antigen-induced bronchoconstriction. Ablukast is LTD4 receptor antagonist.
    Ablukast
  • HY-119018
    AHR-6293 61941-63-7 98%
    AHR-6293 is an orally effective and potent anti-inflammatory agent. AHR-6293 has a better anti-inflammatory effect than AHR-5850, but does not have the activity of inhibiting platelet aggregation.
    AHR-6293
  • HY-119023
    JNJ-26993135 841202-16-2 99.30%
    JNJ-26993135 is a selective leukotriene A4 hydrolase (LTA4H) inhibitor with the IC50 value of 11 nM.
    JNJ-26993135
  • HY-119234
    CX4338 41609-06-7 98%
    CX4338 is a CXCL8-mediated chemokine inhibitor with the activity of inhibiting CXCR2-mediated cell migration. CX4338 selectively inhibits CXCR2-mediated β-arrestin-2 recruitment and receptor internalization while enhancing CXCR2-mediated MAPK activation. CX4338 also inhibited CXCL8-induced chemotaxis, showing efficacy in CXCR2-overexpressing cells and human neutrophils. In vivo, CX4338 significantly reduced LPS-induced neutrophil numbers in mouse bronchoalveolar lavage fluid. The mechanism of action of CX4338 is to selectively inhibit CXCR2-mediated β-arrestin-2 activation, which is sufficient to inhibit CXCL8-mediated chemotaxis.
    CX4338
  • HY-119245
    Udifitimod 1883345-06-9 98%
    Udifitimod (BMS-986166) is a potent, selective and orally active S1P1R modulator. Udifitimod has the potential for the research of autoimmune diseases.
    Udifitimod
  • HY-119296
    Cloprednol 5251-34-3 98%
    Cloprednol is an orally active synthetic glucocorticoid. Cloprednol has anti-inflammatory activity, and can be used in the research of asthma.
    Cloprednol
  • HY-119315
    Flucloronide 3693-39-8 98%
    Flucloronide (Fluclorolone acetonide) is a corticosteroid for topical, and has anti-inflammatory activity.
    Flucloronide
  • HY-119404
    Diproqualone 36518-02-2 98%
    diproqualone is methaqualone analogous with sedative, anxiolytic, anti-inflammatory and analgesic properties.
    Diproqualone
  • HY-119405
    Niddamycin 20283-69-6 98%
    Niddamycin, a macrolide antibiotic, binds 50S ribosomal subunits to inhibit protein synthesis.
    Niddamycin
  • HY-119453
    Oxycinchophen 485-89-2 98%
    Oxycinchophen exhibits anti-inflammatory and uricosuric activity. Oxycinchophen displaces urate from albumin, exhibits high affinity for the DNSA-binding site on the albumin molecule.
    Oxycinchophen
  • HY-119487
    MMPP 1895957-18-2 98%
    MMPP is an anti-inflammatory agent. MMPP prevents LPS-induced mortality by inhibiting the inflammatory response via STAT3 activity inhibition.
    MMPP
  • HY-119517
    Seclazone 29050-11-1
    Seclazone, a heterocyclic compound, possesses anti-inflammatory, analgesic, antipyretic and diuretic properties. Seclazone is orally active.
    Seclazone
  • HY-119527
    Conagenin 134381-30-9 98%
    Conagenin is an immunomodulator. Conagenin shows antitumor effects by activation of T cells and increasing antitumor effector cells.
    Conagenin
  • HY-119582
    Safironil 134377-69-8 98%
    Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation.
    Safironil
  • HY-119658
    PF-4178903 1310796-72-5 98%
    PF-4178903 (INCB10820) is an orally active, potent dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. PF-4178903 is promising for research of chronic inflammatory and autoimmune diseases.
    PF-4178903
Cat. No. Product Name / Synonyms Application Reactivity