2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116120
    N-Acetyldesloratadine 117796-52-8 99.93%
    N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM. N-Acetyldesloratadine can be used for the study of allergic diseases, such as asthma.
    N-Acetyldesloratadine
  • HY-116145
    MHY884 1393371-35-1 98%
    MHY884 is a tyrosinase inhibitor that suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. MHY884 suppresses oxidative stress in the melanoma cells and attenuates UVB-induced oxidative stress, resulting in reduced NF-κB activity in irradiated mice. MHY884 is promising for research of UVB-induced skin damage.
    MHY884
  • HY-116184
    PF-05387252 1604034-71-0 98%
    PF-05387252 is a potent and selective IRAK4 inhibitor with the activity of inhibiting endogenous TLR signaling pathways. PF-05387252 has shown anti-inflammatory activity in experimental models and may have potential clinical application value in inhibiting psoriasis. Although PF-05387252 and its related compounds have shown anti-inflammatory effects in animal models, their efficacy in inhibiting psoriasis has not yet been verified.
    PF-05387252
  • HY-116188
    HX1 1520083-61-7 98%
    HX1 is a potent reversible myeloperoxidase (MPO) inhibitor with an IC50 value of 50 nM. HX1 is bound within the active site cavity above the heme and blocks the substrate channel. HX1 is promising for research of inflammatory diseases.
    HX1
  • HY-116208
    Dalcotidine 120958-90-9 98%
    Dalcotidine (KU-1257) is an orally active and competitive histamine H2 receptor antagonist. Dalcotidine promotes the healing of chronic ulcers and inhibits gastric acid secretion.
    Dalcotidine
  • HY-116209
    Pyrogallol triacetate 525-52-0 98%
    Pyrogallol triacetate (NSC 24068) is used as an antiasthmatic.
    Pyrogallol triacetate
  • HY-116230
    BI-L-45 XX 111317-77-2 98%
    BI-L-45 XX is an orally active anti-inflammatory agent. BI-L-45 XX can inhibit the release of neutrophil enzymes and chemotaxis, and is used in the study of adjuvant-induced arthritis.
    BI-L-45 XX
  • HY-116246
    5(S)-HETE lactone 127708-42-3 98%
    5(S)-HETE lactone is an arachidonic acid (AA) metabolite.
    5(S)-HETE lactone
  • HY-116326
    BayCysLT2 712313-33-2 98%
    BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts.
    BayCysLT2
  • HY-116330
    Hyperforin 11079-53-1 98%
    Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
    Hyperforin
  • HY-116453
    RO5527239 1354812-99-9 98%
    RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificially secrets the endogenous hormone GLP-2.
    RO5527239
  • HY-116549
    Prostaglandin F2α alcohol 13261-27-3 98%
    Prostaglandin F2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
    Prostaglandin F2α alcohol
  • HY-116560
    ONO-8809 123288-47-1 98%
    ONO-8809 is a Thromboxane A2 receptor antagonist. ONO-8809 inhibits the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner.
    ONO-8809
  • HY-116597
    L-783483 194608-77-0 98%
    L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice.
    L-783483
  • HY-116609
    C6 L-threo Ceramide 189894-80-2 98%
    C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. C6 L-threo Ceramide significantly inhibits IL-4 production in T cells. Anti-allergic agents.
    C6 L-threo Ceramide
  • HY-116610
    L 748780 168086-64-4 98%
    L 748780 (compound 2) is a selectivity COX-2 inhibitor with the IC50 values of 0.5 μM and ＞ 100 μM for COX-2 and COX-1, respectively.
    L 748780
  • HY-116662
    CL 232468 96555-65-6 98%
    CL 232468 is an immunosuppressive agent.
    CL 232468
  • HY-116694
    Digallic acid 536-08-3 98%
    Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC50: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus.
    Digallic acid
  • HY-116836
    p38α inhibitor 7 668981-02-0 98%
    p38α inhibitor 7 (compound 1) is an effective p38α inhibitor with oral efficacy and generally favorable pharmacokinetic properties.
    p38α inhibitor 7
  • HY-116866
    Sclerotiorin 549-23-5 98%
    Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
    Sclerotiorin
Cat. No. Product Name / Synonyms Application Reactivity