2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0415S
    Trigonelline-d3 chloride 99.41%
    Trigonelline-d3 (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
    Trigonelline-d3 chloride
  • HY-N10528
    3-Fucosyllactose 41312-47-4 ≥99.0%
    3-Fucosyllactose (3-Fucosyl-D-lactose) is one of the major fucosylated oligosaccharides found in human breast milk. 3-Fucosyllactose shows prebiotic, immunomodulator, neonatal brain development, and antimicrobial function.
    3-Fucosyllactose
  • HY-P1291A
    PKI 14-22 amide,myristoylated TFA 99.38%
    PKI 14-22 amide, myristoylated TFA is a selective, cAMP-dependent, competitive PKA inhibitor with Ki=~36 nM. The myristoylation modification of PKI 14-22 amide, myristoylated TFA makes it more permeable to cell membranes and blood-brain barriers than the precursor molecule. PKI 14-22 amide, myristoylated TFA can block the phosphorylation of cAMP-dependent downstream targets (such as CREB). PKI 14-22 amide, myristoylated TFA can prevent the development of analgesic tolerance in mice, and also inhibits protein translation and negative-strand RNA synthesis of Zika virus. PKI 14-22 amide, myristoylated TFA can be used in research fields such as opioid tolerance mechanisms and antiviral drugs.
    PKI 14-22 amide,myristoylated TFA
  • HY-P5601A
    Thanatin TFA 99.51%
    Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption.
    Thanatin TFA
  • HY-106594A
    Prussian blue insoluble 14038-43-8 ≥99.0%
    Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI).
    Prussian blue insoluble
  • HY-W014612
    Eugenol acetate 93-28-7 99.76%
    Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis.
    Eugenol acetate
  • HY-W072009
    5,7-Dihydroxycoumarin 2732-18-5
    5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-dihydroxycoumarin displays antibacterial characteristics with an MIC value in the range of 1000 mg/mL to >1000 mg/mL. Some 5,7-dihydroxycoumarin derivatives have antioxidant properties.
    5,7-Dihydroxycoumarin
  • HY-W127770
    Pararosaniline hydrochloride 569-61-9
    Pararosaniline hydrochloride (Basic red 9) is a pH-responsive basic dye, as a biological stain to track certain proteins. The pH of the acidified Pararosaniline hydrochloride reagent has a significant effect on the color and the maximum absorption wavelength (λmax) of the reaction system, with its optimum pH 0.48 and a λmax at 549 nm. Pararosaniline hydrochloride is also a strong modifier of RNA splicing. Pararosaniline hydrochloride has been used in the analysis of SO2 and formaldehyde and staining of bacteria or other organisms. Pararosaniline hydrochloride is extensively used in industries like textile, printing, paper, cosmetic, and leather.
    Pararosaniline hydrochloride
  • HY-W412175
    Coproporphyrin III dihydrochloride 68938-73-8 99.57%
    Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6). Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit.
    Coproporphyrin III dihydrochloride
  • HY-17578
    Pneumocandin B0 135575-42-7
    Pneumocandin B0 (L-688786) is the precursor of the synthetic antifungal agent Cancidas (Caspofungin acetate) (HY-17006). Pneumocandin B0 can be isolated from fungus Glarea lozoyensis.
    Pneumocandin B0
  • HY-B1444
    Isoconazole nitrate 24168-96-5 ≥98.0%
    Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential.
    Isoconazole nitrate
  • HY-17589AR
    Chloroquine (Standard) 54-05-7
    Chloroquine (Standard) is the analytical standard of Chloroquine. This product is intended for research and analytical applications. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
    Chloroquine (Standard)
  • HY-W008662
    2'-Deoxy-5'-O-DMT-2'-fluorouridine 146954-74-7 99.94%
    2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.
    2'-Deoxy-5'-O-DMT-2'-fluorouridine
  • HY-W011834
    2'-O-Methylcytidine 2140-72-9 ≥98.0%
    2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.
    2'-O-Methylcytidine
  • HY-W145518
    Pectin 9000-69-5
    Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa.
    Pectin
  • HY-19791
    N-Acetyl-Calicheamicin 108212-76-6 ≥98.0%
    N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC.
    N-Acetyl-Calicheamicin
  • HY-10367A
    Canertinib dihydrochloride 289499-45-2 ≥98.0%
    Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice.
    Canertinib dihydrochloride
  • HY-105048
    Omiganan 204248-78-2 98.64%
    Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne.
    Omiganan
  • HY-107813
    Amikacin sulfate 149022-22-0 99.11%
    Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria.
    Amikacin sulfate
  • HY-124625
    BI-4464 1227948-02-8 98.64%
    BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC50 value of 17 nM. BI-4464 can be used as a PTK2 ligand for constructing proteolysis targeting chimeras (PROTAC).
    BI-4464
Cat. No. Product Name / Synonyms Application Reactivity