2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-172216
    EV-A71-IN-3 98%
    EV-A71-IN-3 (Compound IRE-03-3) is the inhibitor for Enterovirus A71 EV-A71 that targets internal ribosomal entry site (IRES) of EV-A71, inhibits IRES-mediated translation, and inhibits the viral proliferation with an EC50 of 11.96 μM.
    EV-A71-IN-3
  • HY-172223
    3-Deazaguanosine 56039-11-3 98%
    3-Deazaguanosine (C3Guo) has potent antiviral activity against SARS-CoV-2 (EC50: 1.14 μM, CC50: >200 μM for Vero E6 cells). 3-Deazaguanosine prevents COVID-19 pneumonia.
    3-Deazaguanosine
  • HY-172229
    NBTI 5463 1227303-03-8 98%
    NBTI 5463 is a bacterial type II topoisomerases (topoisomerase II) inhibitor with antibacterial activity. NBTI 5463 inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. NBTI 5463 binds to topoisomerase II to prevent DNA cleavage and religation, inhibiting bacterial DNA replication and transcription. NBTI 5463 is promising for research of Gram-negative bacterial infection.
    NBTI 5463
  • HY-172230
    Anti-infective agent 10 1132936-19-6 98%
    Anti-infective agent 10 (Compound Example 30) is a ns5b polymerase inhibitor that can be used as an anti-HCV agent.
    Anti-infective agent 10
  • HY-172250
    8-Hydroxyerythromycin A 51433-35-3 98%
    8-Hydroxyerythromycin is a semi-synthetic antibiotic with an antibacterial activity.
    8-Hydroxyerythromycin A
  • HY-172297
    Pyrazole N-Desmethyl sildenafil 139755-95-6 98%
    Pyrazole N-Desmethyl sildenafil (Compound 10) is an analog of Sildenafil (HY-15025). Pyrazole N-Desmethyl sildenafil shows 16% inhibition on Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) with 100 µM.
    Pyrazole N-Desmethyl sildenafil
  • HY-172390
    Florfenicol-propanoate-piperidin 2975141-09-2 98%
    Florfenicol-propanoate-piperidin (Compound 1) is the derivative of Florfenicol (HY-B1374). Florfenicol-propanoate-piperidin exhibits antibacterial activity, inhibits E. coli ATCC25922, Salmonella CICC110420, S. aureus ATCC29213, B. subtilis CMCC(B)63501, E. faecalis ATCC29212, S. suis CVCC606, and Haemophilus parasuis with MIC of 2-8 μM.
    Florfenicol-propanoate-piperidin
  • HY-172397
    Mycobacterium Tuberculosis-IN-7 98%
    Mycobacterium Tuberculosis-IN-7 (Compound 4c) inhibits M. tuberculosis H37Ra with MIC of 5.34 μg/mL. Mycobacterium Tuberculosis-IN-7 exhibits slight cytotoxicity in cancer cell Vero, A549, and HepG2 (IC50s >50 μM).
    Mycobacterium Tuberculosis-IN-7
  • HY-172408
    NNRT-IN-6 98%
    NNRT-IN-6 (Compound 13a) is the non-nucleoside reverse transcriptase inhibitor (NNRT) for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 0.41 μM. NNRT-IN-6 inhibits HIV-1 wildtype and mutant strains L100I, K103N, Y181C, Y188L, E138K, F227L/V106A and RES056 with EC50 of 6.2-250 nM.
    NNRT-IN-6
  • HY-172447
    1,5-Dideoxy-1,5-imino-D-mannitol 146747-37-7 98%
    1,5-Dideoxy-1,5-imino-D-mannitol is an antibiotic with antibacterial effects.
    1,5-Dideoxy-1,5-imino-D-mannitol
  • HY-172452
    RSV L-protein-6 98%
    RSV L-protein-6 (Compound 19a) is a respiratory syncytial virus polymerase inhibitor, with an IC50 of 13 nM in SPA primer extensions enzymatic assay. RSV L-protein-6 can inhibit RSV replication in Hela cells.
    RSV L-protein-6
  • HY-172462
    Mtb-IN-11 98%
    Mtb-IN-11 (Compound 1e) is an inhibitor of Mycobacterium tuberculosis salicylate synthase (MbtI), with an IC50 of 11.2 μM. Mtb-IN-11 exhibits good in vitro anti-tuberculosis activity, with a MIC99 of 32 μM against M. bovis BCG. Mtb-IN-11 can be used for the research of tuberculosis.
    Mtb-IN-11
  • HY-172515
    ent-Oseltamivir 1035895-88-5 98%
    ent-Oseltamivir, the enantiomer of Oseltamivir (HY-13317), is a neuraminidase (NA) of influenza virus inhibitor. ent-Oseltamivir is promising for research of influenza virus infections.
    ent-Oseltamivir
  • HY-172602
    ROS inducer 9 3081689-97-3 98%
    ROS inducer 9 (compound 4e) is an antibacterial agent with a MIC value of 0.25 μg/mL against E. coli. ROS inducer 9 kills bacteria by inhibiting GSH activity and increasing ROS levels. ROS inducer 9 shows low toxicity to erythrocytes and RAW 264.7 cells.
    ROS inducer 9
  • HY-172603
    HIV-1 inhibitor-82 43099-56-5 98%
    HIV-1 inhibitor-82 (Compound L14) is an orally active small-molecule entry inhibitor for HIV-1 with an IC50 value of 0.39 μM. HIV-1 inhibitor-82 is promising for research of anti-HIV-1 infection.
    HIV-1 inhibitor-82
  • HY-172676
    GW461484A 401815-65-4 98%
    GW461484A is a small-molecule inhibitor targeting Candida albicans Yck2, with an IC50 of 0.11 µM. It exhibits antifungal activity against C. albicans with a MIC80 of 12.5 µM. GW461484A holds potential for research on fungal diseases, such as drug-resistant Candida infections.
    GW461484A
  • HY-172705
    DSPE-PEG2000-RVG29 98%
    DSPE-PEG2000-RVG29 is a PEG compound which composed of DSPE and a Rabies virus glycoprotein 29 (RVG29). RVG29 can bind specifically to the nicotinic acetylcholine receptor (nAChR) at the blood-brain barrier (BBB) and cross over the BBB.
    DSPE-PEG2000-RVG29
  • HY-172793
    Antibacterial agent 276 98%
    Antibacterial agent 276 (compound B3) is an antibacterial agent with EC50 values of 1.32 μg/mL and 2.80 μg/mL against Xanthomonas oryzae pv.oryzae and Xanthomonas axonopodis pv.citri，respectively. Antibacterial agent 276 disrupts the intracellular redox balance, and results in the accumulation of reactive oxygen species (ROS) and subsequent induction of apoptosis.
    Antibacterial agent 276
  • HY-172945
    LpxC-IN-16 98%
    LpxC-IN-16 (Compound P-2) is an LpxC inhibitor. LpxC-IN-16 has anti-MDR P. aeruginosa activity.
    LpxC-IN-16
  • HY-173009
    PROTAC CG167 98%
    PROTAC CG167 is a selective and potent CypA PROTAC degrader. PROTAC CG167 degrades CypA in a dose-dependent manner (Jurkat: DC50: 123 nM). PROTAC CG167 can inhibit HIV-1 and HCV and exhibits antiviral activity. (Pink: CypA Ligand (HY-170997); Black: Linker (HY-W123015); Blue: E3 Ligase Ligand (HY-112078))
    PROTAC CG167
Cat. No. Product Name / Synonyms Application Reactivity