2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-169818
    Keto lovastatin 96497-73-3 98%
    Keto lovastatin is an impurity of Lovastatin (HY-N0504) with antibacterial activity. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
    Keto lovastatin
  • HY-169823
    BAS-118 218936-13-1 98%
    BAS-118 is a benzamide derivative with antibacterial activity. The MIC50, MIC90 and MIC ranges of BAS-118 for 100 randomly selected isolates of Helicobacter pylori are ≤0.003, 0.013 and ≤0.003-0.025 mg/L, respectively. BAS-118 is promising for research of anti-H. pylori agent.
    BAS-118
  • HY-169848
    (S)-Batylalcohol 6129-13-1 98%
    (S)-Batylalcohol (1-O-Octadecyl-sn-glycerol) is a phosphonoformic acid (PFA) analog that exhibits higher in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1) than PFA. (S)-Batylalcohol can be used in antiretroviral research.
    (S)-Batylalcohol
  • HY-169856
    Pradimicin L 142062-87-1 98%
    Pradimicin L is a homologue of pradimicin A (HY-132191) that can be isolated from the new type of Streptomyces madurensis, and it has antifungal activity.
    Pradimicin L
  • HY-169916
    GuaB-IN-1 98%
    GuaB-IN-1 (Compound 15) exhibits high potency against M.tb with a MIC value of 0.25 μM. GuaB-IN-1 has a favorable 28% hERG inhibition profile at 10 μM. GuaB-IN-1 is promising for research of tuberculosis.
    GuaB-IN-1
  • HY-169919
    HDM-IN-1 3020690-76-7 98%
    HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model.
    HDM-IN-1
  • HY-169920
    HIV-1 inhibitor-79 98%
    HIV-1 inhibitor-79 (Compound 3k) is an HIV inhibitor that exhibits significant inhibitory activity against HIV-1 and its common mutant strains (with IC50 values of 1.9, 1.9, 8.7, and 11 nM against HIV-1, K103, L100I, and E138K, respectively), and has low cytotoxicity and a high selectivity index (CC50 = 21.95 μM, SI = 11478). Additionally, HIV-1 inhibitor-79 also shows antiviral activity against HIV-2, with an EC50 value of 6.14 μM, and significantly inhibits the activity of HIV-1 reverse transcriptase (IC50 = 25 nM).
    HIV-1 inhibitor-79
  • HY-169942
    3-(1-Carboxyvinyloxy)benzoic acid 16929-37-6 98%
    3-(1-Carboxyvinyloxy)benzoic acid is an inhibitor of MbtI (Mycobacterium tuberculosis salicylate synthase) and AS (Serratia marcescens arginine synthase), with Ki values of 500 and 3.2 µM, respectively. 3-(1-Carboxyvinyloxy)benzoic acid has antibacterial activity and can be used in anti-infection research.
    3-(1-Carboxyvinyloxy)benzoic acid
  • HY-169972
    Succinate dehydrogenase-IN-5 98%
    Succinate dehydrogenase-IN-5 (Compound M8) is the inhibitor for succinate dehydrogenase. Succinate dehydrogenase-IN-5 interfers with the energy metabolism and growth of fungi, inhibits Rhizoctonia solani, Sclerotinia sclerotiorum, Botrytis cinerea and Fusarium graminearum with EC50 < 0.3 μg/mL.
    Succinate dehydrogenase-IN-5
  • HY-169973
    PhoPS 98%
    PhoPS is the photocaged inhibitor for β-lactamase. PhoPS is activated upon light irradiation, and active β-lactamase inhibitor Sulbactam (HY-B0334) is released. PhoPS inhibits the synthesis of bacterial cell wall and the formation of E. coli biofilm, exhibits antimicrobial activity.
    PhoPS
  • HY-169974
    SARS-CoV-2-IN-107 98%
    SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages.
    SARS-CoV-2-IN-107
  • HY-169987
    bc1 Complex-IN-1 2883052-97-7 98%
    bc1 Complex-IN-1 (compound 12g) is a potent bc1 complex inhibitor. bc1 Complex-IN-1 shows fungicidal properties against Cucumber downy mildew (CDM).
    bc1 Complex-IN-1
  • HY-169998
    XJ5 98%
    XJ5 is a non-nucleoside covalent inhibitor of Nsp12 (IC50=0.12 μM), which is the non-structural protein 12 of the virus. XJ5 has the potential to be an antiviral inhibitor of SARS-CoV-2.
    XJ5
  • HY-169999
    AAP4 98%
    AAP4 is a potent OfChi-h and OfHex1 inhibitor with Ki values of 29.3 nM and 4.9 μM, respectively. AAP4 shows insecticidal activity for lepidopteran pests Ostrinia furnacalis.
    AAP4
  • HY-170028
    NL3 2395867-03-3 98%
    NL3 is a bacterial cystathionine γ-lyase inhibitor, with IC50s of 0.7 μM (bCSE) and 3.4 μM (hCSE) respectively. NL3 can be used for antimicrobial and circumventing bacterial resistance research.
    NL3
  • HY-17007R
    Saquinavir (Standard) 127779-20-8
    Saquinavir (Standard) (Ro 31-8959 (Standard)) is the analytical standard of Saquinavir (HY-17007). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
    Saquinavir (Standard)
  • HY-17008R
    Toltrazuril (sulfone) (Standard) 69004-04-2
    Toltrazuril (sulfone) (Standard) is the analytical standard of Toltrazuril (sulfone). This product is intended for research and analytical applications. Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry.
    Toltrazuril (sulfone) (Standard)
  • HY-17015R
    Peramivir trihydrate (Standard) 1041434-82-5
    Peramivir (trihydrate) (Standard) is the analytical standard of Peramivir (trihydrate). This product is intended for research and analytical applications. Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes.
    Peramivir trihydrate (Standard)
  • HY-170219
    RMM23 98%
    RMM23 is an inhibitor targeting PfBDP1 with a Kd value of 1.24 μM. RMM23 against the wild-type strains 3D7 and NF54, and the multidrug-resistant K1 strain in vitro blood stage, with EC50 values of 18 μM, 14 μM, 20 μM, respectively .
    RMM23
  • HY-17025R
    Rifabutin (Standard) 72559-06-9
    Rifabutin (Standard) is the analytical standard of Rifabutin. This product is intended for research and analytical applications. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.
    Rifabutin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity