2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-155479
    PqsR-IN-3 3033007-79-0 98%
    PqsR-IN-3 (compound 16e) is a selective inhibitor of the pqs system (IC50=3.7 μM) and its associated virulence factor pyocyanin (IC50=2.7 μM). PqsR-IN-3 inhibits bacterial biofilm synthesis and is significantly cytotoxic against Pseudomonas aeruginosa. PqsR-IN-3 has synergistic effects with several antibiotics, such as Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441).
    PqsR-IN-3
  • HY-155601
    SARS-CoV-2-IN-52 1001242-49-4 98%
    SARS-CoV-2-IN-52 (Compound 5) is an inhibitor for SARS-CoV-2 with a pIC50 of 0.3187.
    SARS-CoV-2-IN-52
  • HY-15592R
    Cabotegravir (Standard) 1051375-10-0
    Cabotegravir (Standard) is the analytical standard of Cabotegravir. This product is intended for research and analytical applications. Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS.
    Cabotegravir (Standard)
  • HY-155999
    MoTPS1-IN-1 2991072-02-5 99.50%
    MoTPS1-IN-1 (Compound j11), an antifungal agent, is a MoTPS1 inhibitor. MoTPS1-IN-1 acts by interation with Glu396 in MoTPS1. MoTPS1-IN-1 inhibits pathogenicity of M. oryzae.
    MoTPS1-IN-1
  • HY-156007
    SARS-CoV-2 3CLpro-IN-21 3052835-22-7 98%
    SARS-CoV-2 3CLpro-IN-21 (Compound D6) irreversibly and covalently inhibits SARS-CoV-2 3CLpro with an IC50 of 0.03 μM. SARS-CoV-2 3CLpro-IN-21 also inhibits SARS-CoV-13CLpro with an IC50 of 0.12μM.
    SARS-CoV-2 3CLpro-IN-21
  • HY-156021
    Antitubercular agent-40 900314-03-6 98%
    Antitubercular agent-40 (compound 93) is a thieno[2,3-b]quinoline-2-carboxamide compound with potential antitubercular activity.
    Antitubercular agent-40
  • HY-15602D
    Ledipasvir (diacetone) 1502655-48-2 98%
    Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
    Ledipasvir (diacetone)
  • HY-156074
    Erythromycin propionate 134-36-1 98%
    Erythromycin propionate, erythromycin (HY-B0220) derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin propionate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin propionate toxicity is related to its inhibitory effect on bile acid transport.
    Erythromycin propionate
  • HY-156191
    Cholic acid anilide 6912-96-5 98%
    Cholic acid anilide, a Narylcholan-24-amide, is a potent inhibitor of C. difficile spore germination with an IC50 value of 1.8 μM in the spore germination assay conducted in Sodium phosphate media containing 6 mM Taurocholate (HY-B1131) and 12 mM Glycine (HY-Y0966). Cholic acid anilide has the potential for C. difficile infections research.
    Cholic acid anilide
  • HY-156195
    BHBM 302807-84-7 98%
    BHBM (compound 1) is an aromatic acylhydrazone antifungal agent with high bactericidal activity against Cryptococcus neoformans.
    BHBM
  • HY-156198
    Bottromycin A2 15005-62-6 98%
    Bottromycin A2 is a natural antibiotic. Bottromycin A2 is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
    Bottromycin A2
  • HY-156205
    CdnP-IN-1 691862-35-8 98%
    CdnP-IN-1 (compound c82) is a potent and selective non-nucleotide MTB CDN PDE (CdnP; Mycobacterium tuberculosis cyclic dinucleotide phosphodiesterase) inhibitor with an IC50 of 18 μM. CdnP-IN-1 does not inhibit the enzymatic activities of three other bacterial CDN PDEs (Yybt, RocR, and GBS-CdnP), a viral CDN PDE (poxin) or mammalian ENPP1.
    CdnP-IN-1
  • HY-156412
    DHFR-IN-10 929484-47-9 98%
    DHFR-IN-10 (compound 4c) is a potent DHFR inhibitor, with an IC50 of 4.21 μM for M. tuberculosis DHFR enzyme. DHFR-IN-10 exhibits potent antituberculosis efficiency.
    DHFR-IN-10
  • HY-156414
    DHFR-IN-11 98%
    DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC50 values 5.70 μM.
    DHFR-IN-11
  • HY-156416
    LtaS-IN-2 98%
    LtaS-IN-2 (compound 13) is a inhibitor of LTA synthesis, and shows antibacterial activity against S. aureus and S. epidermidis, with the MIC90 of 0.5 μg/mL and 1 μg/mL, respectively. LtaS-IN-2 is a derivative of LtaS-IN-1 (HY-135813).
    LtaS-IN-2
  • HY-156421
    QST4 2991427-35-9 99.23%
    QST4 has antitubercular activity, with the MIC value of 6.25 μM in Mycobacterium tuberculosis H37Rv.
    QST4
  • HY-156427
    Antileishmanial agent-25 98%
    Antileishmanial agent-25 (compound 24) is selective antileishmanial activity on intracellular amastigotes, with the IC50 of 6.63 μM.
    Antileishmanial agent-25
  • HY-156440
    7-51A 98%
    7-51A is a potent PB2 inhibitor with a KD value of 1.64 nM as determined by ITC. PB2 is an essential subunit of influenza RNA-dependent RNA polymerase (RdRP).
    7-51A
  • HY-156456
    Elastase LasB-IN-1 2762675-17-0 98%
    Elastase LasB-IN-1 (Compound 4b) has antibacterial activity. Elastase LasB-IN-1 (Compound 4b) is a selective elastase LasB inhibitor with an IC50 value of 76 nM.
    Elastase LasB-IN-1
  • HY-156462
    Topoisomerase I inhibitor 9 1228150-86-4 98%
    Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 34.81μM.
    Topoisomerase I inhibitor 9
Cat. No. Product Name / Synonyms Application Reactivity