2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-137034
    (+)-Secolongifolene-diol 53587-37-4 98%
    (+)-Secolongifolene-diol is a sesquiterpene, that can be isolated from the marine fungal Drechslera sp. (+)-Secolongifolene-diol exhibits slightly weak effectiveness in antioxidation, antimicrobial and antifouling aspects.
    (+)-Secolongifolene-diol
  • HY-137084
    Antibiotic AB023a 141443-39-2 98%
    Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum.
    Antibiotic AB023a
  • HY-137085
    Antibiotic AB023b 141443-40-5 98%
    Antibiotic AB023b is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023a (HY-137084). Antibiotic AB023b exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea, Fusarium moniliforme and Pythium ultimum.
    Antibiotic AB023b
  • HY-137121
    YKAs3003 329180-48-5 98%
    YKAs3003 is a potent inhibitor of Escherichia coli KAS III (ecKAS III) with antibacterial activity. The minimum inhibitory concentrations (MICs) of YKAs3003 against a variety of bacteria ranged from 128 to 256 μg/mL.
    YKAs3003
  • HY-137126
    Photosensitizer Pc 4 135719-28-7 98%
    Photosensitizer Pc 4 (NSC-676418) is a photosensitizer, which inhibits Plasmodium falciparum in dark or under red light by disturbing the protein/DNA synthesis, with an IC50 of 24 nM.
    Photosensitizer Pc 4
  • HY-137139
    10'-Desmethoxystreptonigrin 136803-89-9 98%
    10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg).
    10'-Desmethoxystreptonigrin
  • HY-13718A
    Oglufanide disodium 237068-57-4 98%
    Oglufanide (H-Glu-Trp-OH) disodium is a dipeptide immunomodulator isolated from calf thymus. Oglufanide disodium inhibits vascular endothelial growth factor (VEGF). Oglufanide disodium can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide disodium shows antitumor and anti-angiogenesis activities.
    Oglufanide disodium
  • HY-137229
    Avermectin B1a monosaccharide 71831-09-9 98%
    Avermectin B1a monosaccharide is a macrolide anthelmintic that can inhibit Caenorhabditis elegans.
    Avermectin B1a monosaccharide
  • HY-137252
    22,23-Dihydroavermectin B1a aglycon 73162-95-5 98%
    22,23-Dihydroavermectin B1a aglycon is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.
    22,23-Dihydroavermectin B1a aglycon
  • HY-13725R
    Pirarubicin (Standard) 72496-41-4
    Pirarubicin (Standard) is the analytical standard of Pirarubicin. This product is intended for research and analytical applications. Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.
    Pirarubicin (Standard)
  • HY-137263
    Propionylmaridomycin 35775-65-6 98%
    Propionylmaridomycin is a macrolide antibiotic with antibacterial activity. Propionylmaridomycin is rapidly absorbed from the gastrointestinal tract and rapidly distributed to tissues. Propionylmaridomycin radioactivity levels in the liver, kidneys, and lungs were significantly higher than in plasma, while distribution to the brain was less. Propionylmaridomycin is excreted primarily through the feces, and the high fecal recovery rate is due to unabsorbed compounds and biliary excretion of compounds and their metabolites. Propionylmaridomycin exhibits the highest antibacterial activity in the lungs. Propionylmaridomycin is completely converted to several metabolites in rats, of which 4''-depropionyl-9-propionylmaridomycin was identified as the major metabolite.
    Propionylmaridomycin
  • HY-137323
    Leucinostatin H 109539-58-4 98%
    Leucinostatin H is a polypeptide antibiotic discovered in Paecilomyces marquandii, characterized by a tertiary amine-oxide terminal group. Leucinostatin H exhibits inhibitory activity against Gram-positive bacteria, such as Bacillus subtilis, B. cereus, and Staphylococcus aureus (MIC 10-100 μg/mL). Leucinostatin H holds potential for research in anti-infective and plant disease control applications.
    Leucinostatin H
  • HY-137324
    α-Apooxytetracycline 18695-01-7 98%
    α-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class.
    α-Apooxytetracycline
  • HY-13735E
    Quinacrine methanesulfonate 316-05-2 98%
    Quinacrine (Mepacrine) methanesulfonate is a potent, orally active antimalarial agent with antitumor effects in vitro and in vivo. Quinacrine dihydrochloride inhibits NF-κB and activates p53 signaling, inducing apoptosis in tumor cells.
    Quinacrine methanesulfonate
  • HY-137564
    Desacetylcephalothin sodium 5547-29-5 98%
    Desacetylcephalothin sodium is a metabolite of Cephalothin (HY-B1275A). Desacetylcephalothin sodium exhibits a weak antimicrobial activity.
    Desacetylcephalothin sodium
  • HY-137613
    Sp-TTPαS 83199-32-0 98%
    Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) catalysis inhibitor. Sp-TTPαS competitively inhibits TTP hydrolysis with a Ki value of 46 µM.
    Sp-TTPαS
  • HY-137956
    Previridicatumtoxin 1379585-81-5 98%
    Previridicatumtoxin is a fungal metabolite with antibacterial and anticancer activities. Previridicatumtoxin can be extracted from P. aethiopicum and utilized in research related to cancer as well as infections.
    Previridicatumtoxin
  • HY-137968
    Avermectin B1a aglycon 71828-14-3 98%
    Avermectin B1a aglycon is an aglycone derivative of Avermectin B1a (HY-15308), an antiparasitic agent that paralyzes nematodes. Avermectin B1a aglycon hyperpolarizes P. crassipes muscle fibers, with a minimum effective concentration of 0.1 μM.
    Avermectin B1a aglycon
  • HY-137970
    Spinosyn D aglycone 149439-79-2 98%
    Spinosyn D aglycone is an aglycone form of the insecticide Spinosyn D (HY-125326). Unlike spinosyn D, spinosyn D aglycone is not lethal to H. virescens (tobacco budworm) neonate larvae (LC50=>64 ppm).
    Spinosyn D aglycone
  • HY-13801R
    Fexinidazole (Standard) 59729-37-2
    Fexinidazole (Standard) is the analytical standard of Fexinidazole. This product is intended for research and analytical applications. Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei.
    Fexinidazole (Standard)
Cat. No. Product Name / Synonyms Application Reactivity