2. Infection

Infection

Infection

Related Products

PDF 70.44 MB

Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130596
    DC-86-M 94448-15-4 98%
    DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD50 of 25 mg/kg.
    DC-86-M
  • HY-13062R
    Daunorubicin hydrochloride (Standard) 23541-50-6
    Daunorubicin (hydrochloride) (Standard) is the analytical standard of Daunorubicin (hydrochloride). This product is intended for research and analytical applications. Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
    Daunorubicin hydrochloride (Standard)
  • HY-130743
    Dieugenol 4433-08-3 98%
    Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
    Dieugenol
  • HY-130748
    K-252d 105114-22-5 98%
    K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM).
    K-252d
  • HY-130752
    VNI 1246770-52-4 98%
    VNI is an effective inhibitor of CYP51. VNI can inhibit sterol synthesis in Trypanosoma cruzi, exhibiting anti-Trypanosoma cruzi activity.
    VNI
  • HY-130772
    Filipin II 38620-77-8 98%
    Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L.
    Filipin II
  • HY-131044
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione 36140-65-5 98%
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL.
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione
  • HY-131049
    Antimicrobial agent-30 24138-83-8 98%
    Antimicrobial agent-30 (Compound T10) is an antimicrobial agent, with MIC values of 18.7-21.0 µg/mL for S. aureus, S. epidermidis, E. coli, P. aeruginosa, A. niger, and A. fumigatus.
    Antimicrobial agent-30
  • HY-131050
    Aspergillus niger-IN-1 6325-94-6 98%
    Aspergillus niger-IN-1 (Compound 17), a derivative of thiazolidine-2,4-dione, acts as an antimicrobial agent. Aspergillus niger-IN-1 exhibited antimicrobial activity against various bacterial and fungal strains, including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, Salmonella typhi, Candida albicans and Aspergillus niger, with MIC values of 11.3, 5.65, 11.3, 5.65, 5.65, 5.65, and 5.65 μM/mL, respectively .
    Aspergillus niger-IN-1
  • HY-131300
    Colchicoside 477-29-2 99.37%
    Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities.
    Colchicoside
  • HY-131422
    (Rac)-8-Hydroxy-efavirenz 205754-32-1 98%
    (Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz (HY-10572), a non-nucleoside HIV-1 reverse transcriptase inhibitor.
    (Rac)-8-Hydroxy-efavirenz
  • HY-131518
    Lycomarasmin 7611-43-0 98%
    Lycomarasmin has the inhibitory effect of lactobacillus casei, and it is a plant toxin.
    Lycomarasmin
  • HY-132186
    Abacavir carboxylate 384380-52-3 98%
    Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor Abacavir (HY-17423).
    Abacavir carboxylate
  • HY-13231R
    CDK9-IN-1 (Standard) 1415559-43-1
    CDK9-IN-1 (Standard) is the analytical standard of CDK9-IN-1. This product is intended for research and analytical applications. CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87.
    CDK9-IN-1 (Standard)
  • HY-13234R
    Rifaximin (Standard) 80621-81-4
    Rifaximin (Standard) is the analytical standard of Rifaximin. This product is intended for research and analytical applications. Rifaximin, a gastrointestinal-selective antibiotic, binds the β-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of bacterial RNA synthesis. Rifaximin susceptibility is higher against Gram-positive strains (MIC: 0.03-5 mg/ml) compared to Gram-negative bacteria (MIC: 8-50 mg/mL).
    Rifaximin (Standard)
  • HY-13238R
    Dolutegravir (Standard) 1051375-16-6
    Dolutegravir (Standard) is the analytical standard of Dolutegravir. This product is intended for research and analytical applications. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
    Dolutegravir (Standard)
  • HY-13269R
    BMS-707035 (Standard) 729607-74-3
    BMS-707035 (Standard) is the analytical standard of BMS-707035. This product is intended for research and analytical applications. BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1).
    BMS-707035 (Standard)
  • HY-133001
    Dehydrocyclopeptine 31965-37-4 98%
    Dehydrocyclopeptine is an intermediate in the synthesis of benzodiazepine alkaloids in Penicillium.
    Dehydrocyclopeptine
  • HY-133060
    Sannamycin B 72503-80-1 98%
    Sannamycin B is an aminoglycoside antibiotic. Sannamycin B has only weak antibacterial activity against a few bacteria.
    Sannamycin B
  • HY-13317R
    Oseltamivir (Standard) 196618-13-0
    Oseltamivir (Standard) is the analytical standard of Oseltamivir. This product is intended for research and analytical applications. Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively.
    Oseltamivir (Standard)
Cat. No. Product Name / Synonyms Application Reactivity