2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116700
    Hinnuliquinone 78860-37-4 98%
    Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum.
    Hinnuliquinone
  • HY-116736
    BRD7539 2057420-00-3 98%
    BRD7539 is a PfDHODH inhibitor (IC50 = 0.033 μM). BRD7539 has potent activity against both multidrug-resistant asexual blood-stage (P. falciparum, Dd2 strain, EC50 = 0.010 μM) and liver-stage (P. berghei, EC50 = 0.015 μM) parasites.
    BRD7539
  • HY-116847
    Leucodelphinidin 491-52-1 98%
    Leucodelphinidin (Leukoefdin) is a flavonoid found in Terminalia plants with antiplasmodial activity against Plasmodium falciparum (3D7 and Dd2 strains). Leucodelphinidin exhibits cytotoxicity (CC50>250 μg/mL) toward Vero and Raw 264.7 cells. Leucodelphinidin is promising for research of antimalarial agents.
    Leucodelphinidin
  • HY-116870
    Vamidothion 2275-23-2 98%
    Vamidothion is a polar organophosphorus insecticide and acaricide with biological activity against insects and mites. Vamidothion is degraded by human serum albumin (HSA) and promotes adduct formation with tyrosine residues. The phosphate amino acid adducts formed after the reaction of vamidothion with HSA are detected by liquid chromatography quadrupole-Orbitrap mass spectrometry. The metabolites of vamidothion can be used in forensic toxicology to help determine deaths caused by organophosphorus poisoning.
    Vamidothion
  • HY-116943
    MTC420 2088930-66-7 98%
    MTC420 (compound 42a) is a heterocyclic quinolone compound that targets the respiratory chain of Mycobacterium tuberculosis and exhibits antituberculosis activity (Rep Mtb: IC50=525 nM, Wayne Mtb: IC50=76 nM, MDR Mtb: IC50=140 nM).
    MTC420
  • HY-117146
    Indoxacarb 173584-44-6 98%
    Indoxacarb ((S)-DPX-JW062) is an oxathiazole insecticide with activity against a wide range of insect pests. Indoxacarb is used in forest pest management to control insect pests, and its toxicity has significant effects on adult individuals of the predatory stink bug Podisus distinctus. Indoxacarb showed high toxicity to P. distinctus at a lethal concentration (LC50 = 2.62 g L-1). Indoxacarb treatment significantly reduced the survival rate of P. distinctus, with the survival rate of individuals exposed to 2.62 g L-1 decreasing to 40.7%. Indoxacarb also reduced the respiration rate of P. distinctus from 18.45 to 14.41 μL CO2 h-1, and inhibited its food intake. P. distinctus showed hyperexcitatory responses after Indoxacarb treatment.
    Indoxacarb
  • HY-117166
    Naftoxate 28820-28-2 98%
    Naftoxate is an ester compound containing aminomethylsulfate, and its ammonium salt analog can inhibit free thiols to chemically weaken the reactive oxygen species (ROS)-sensitive anaerobic bacterium Trichomonas vaginalis and inhibit common pathogens causing vaginal infections: Candida albicans and Staphylococcus aureus.
    Naftoxate
  • HY-117204
    AA-57 68026-87-9 98%
    AA-57 is an acidic lipophilic antibiotic isolated from the fermentation broth of Actinomycetes strain AA-57. The AA-57 strain was isolated from a soil sample collected in Koriyama City, Fukushima Prefecture, Japan. AA-57 has antibacterial properties against Gram-positive bacteria, Gram-negative bacteria, and acid-fast bacteria. AA-57 was discovered by screening actinomycete cultures for antibacterial properties. AA-57 exhibits significant antibacterial activity and has inhibitory effects against a variety of bacteria. The discovery of AA-57 provides new possibilities for antibacterial therapy.
    AA-57
  • HY-117241
    AB 3217-B 139159-00-5 98%
    AB 3217-B is an analog of AB 3217-A and has anti-mite activity.
    AB 3217-B
  • HY-117247
    5,6,7,8-Tetrahydro-8-deazahomofolic acid 111113-75-8 98%
    5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase.
    5,6,7,8-Tetrahydro-8-deazahomofolic acid
  • HY-117250
    EcDsbB-IN-10 112749-52-7 98.71%
    EcDsbB-IN-10 (compound 12) is an inhibitor of EcDsbB (E. coli DsbB) enzyme, with a Ki of 0.8 nM and an IC50 of 18.85 nM.
    EcDsbB-IN-10
  • HY-117254
    BAS00127538 110673-34-2 98%
    BAS00127538 is a Lipid II inhibitor with antibacterial activity. As the first small molecule Lipid II inhibitor, BAS00127538 has a structure that is significantly different from compounds that naturally bind to Lipid II, such as vancomycin. The activity of BAS00127538 in terms of cytotoxicity and Lipid II binding is of great significance in antibacterial effects. Studies on BAS00127538 have shown that it has the potential to inhibit infection.
    BAS00127538
  • HY-117375
    Brotianide 23233-88-7 98%
    Brotianide is a potent anti-parasitic agent. Brotianide can be used to study liver fluke and gastric fluke infestations.
    Brotianide
  • HY-117387
    BFE-37 107572-73-6 98%
    BFE-37 is a yeast introduction with heat resistance activity. The survival rate change of BFE-37 after heating at 55 °C for 5 minutes was 6.53 log CFU/mL, showing its strong heat resistance in acidic orange juice. The dynamic behavior of BFE-37 at different temperatures showed a first-order logarithmic linear inactivation characteristic, which indicates its stability in heat treatment. The study of BFE-37 helps to understand the effect of mild heat treatment on juice and provide guidance for microbial control in the food industry.
    BFE-37
  • HY-117424
    Inz-4 1585213-98-4 98%
    Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1, with the IC50 of 0.026 μM.
    Inz-4
  • HY-117434
    Suberosol 151368-42-2 98%
    Suberosol, a C31 lanostane-type triterpene, is an anti-HIV drug. Suberosol shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 μg/mL.
    Suberosol
  • HY-117451
    Dodine 2439-10-3 98%
    Dodine is a fungicide with plant disease suppressive activity. Dodine is used to control black spot on apples, pears and pecans, brown rot on peaches, and a variety of foliar diseases of peaches, strawberries, cherries, jacaranda and black walnuts. Dodine is also used as an industrial biocide and preservative.
    Dodine
  • HY-117472
    DLC27-14 1360869-92-6 98%
    DLC27-14 is a HIV Nef inhibitor with the IC50 of 15.92 μM. DLC27-14 can be used for study of HIV-1.
    DLC27-14
  • HY-117477
    DPC 963 214287-90-8 98%
    DPC-963 is an oral active non-nucleoside reverse transcriptase inhibitor with the IC50 of 18 nM. DPC-963 can be used for study of HIV.
    DPC 963
  • HY-117496
    Ampelopsin A 130608-11-6 98%
    Ampelopsin A is a antifungal agent and can be isolated from the Vitis vinifera canes. Ampelopsin A shows neuroprotective effects.
    Ampelopsin A
Cat. No. Product Name / Synonyms Application Reactivity