2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-10466R
    Daclatasvir (Standard) 1009119-64-5 98%
    Daclatasvir (Standard) is the analytical standard of Daclatasvir. This product is intended for research and analytical applications. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively.
    Daclatasvir (Standard)
  • HY-10468R
    NM107 (Standard) 20724-73-6 98%
    NM107 (Standard) is the analytical standard of NM107. This product is intended for research and analytical applications. NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM.
    NM107 (Standard)
  • HY-10493R
    Cobicistat (Standard) 1004316-88-4
    Cobicistat (Standard) is the analytical standard of Cobicistat. This product is intended for research and analytical applications. Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.
    Cobicistat (Standard)
  • HY-105041
    Tedizolid phosphate sodium 856867-39-5 98%
    Tedizolid phosphate (TR-701FA) sodium is a MAO-A and MAO-B inhibitor with activity against Gram-positive bacteria.
    Tedizolid phosphate sodium
  • HY-105110
    SCH 39304 120924-80-3 98%
    SM-8668 is an effective orally active antifungal agent, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg for systemic candidiasis, aspergillosis, and cryptococcosis in mice, respectively. Pharmacokinetic studies in mice and rats indicate that SM-8668 has a long half-life and a high total exposure. SM-8668 can be used in anti-infective research.
    SCH 39304
  • HY-105113
    Cefluprenam 116853-25-9 98%
    Cefluprenam is a β-lactam antibiotic with broad-spectrum antibacterial activity.
    Cefluprenam
  • HY-105180
    Lenapenem 149951-16-6 98%
    Lenapenem (BO-2727 free acid), a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa.
    Lenapenem
  • HY-105191
    Azalanstat 143393-27-5 98%
    Azalanstat is an imidazole-dioxolane derivate that is a lanosterol 14-α demethylase inhibitor. Azalanstat is also a HO-1 (IC50 = 5.5 µM) and HO-2 (IC50 = 24.5 µM) inhibitor.
    Azalanstat
  • HY-105267
    LY 121019 79404-91-4 98%
    LY 121019 is a semi-synthetic antifungal antibiotic with strong anticandida activity with MIC50 value of 0.625 μg/mL.
    LY 121019
  • HY-105350
    Pristinamycin IB 57206-54-9 98%
    Pristinamycin IB (Ostreogrycin B2) is an ester peptide antibiotic with anti-Gram-positive bacteria effects.
    Pristinamycin IB
  • HY-105393
    LB 10517 sodium 175553-22-7 98%
    LB 10517 (sodium) is a type of cephalosporin. LB 10517 (sodium) has broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus, and Streptococcus.
    LB 10517 sodium
  • HY-105463
    Saptomycin D 137714-91-1 98%
    Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology.
    Saptomycin D
  • HY-105477
    Maniwamycin A 122566-70-5 98%
    Maniwamycin A ((-)-Maniwamycin A) has anti-fungal effect.
    Maniwamycin A
  • HY-105589
    Liroldine 105102-20-3 98%
    Liroldine (Compound 10) is an anti-amebic agent that exhibits effective anti-amebic activity in both the intestines and livers of mice. Liroldine can be utilized for the research of amebiasis.
    Liroldine
  • HY-10571R
    Delavirdine (Standard) 136817-59-9 98%
    Delavirdine (Standard) is the analytical standard of Delavirdine. This product is intended for research and analytical applications. Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs.
    Delavirdine (Standard)
  • HY-10572S
    Efavirenz-d5 1132642-95-5 98%
    Efavirenz-d5 (DMP 266-d5) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture. Efavirenz-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Efavirenz-d5
  • HY-10574R
    Rilpivirine (Standard) 500287-72-9 98%
    Rilpivirine (Standard) is the analytical standard of Rilpivirine. This product is intended for research and analytical applications. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV.
    Rilpivirine (Standard)
  • HY-105751
    Kalafungin 11048-15-0 98%
    Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria.
    Kalafungin
  • HY-10581B
    Gatifloxacin mesylate 316819-28-0 98%
    Gatifloxacin mesylate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin mesylate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin mesylate can be used to treat bacterial conjunctivitis in vivo.
    Gatifloxacin mesylate
  • HY-10581R
    Gatifloxacin (Standard) 112811-59-3
    Gatifloxacin (Standard) is the analytical standard of Gatifloxacin. This product is intended for research and analytical applications. Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50=0.109 μg/ml). Gatifloxacin can be used to treat bacterial conjunctivitis in vivo.
    Gatifloxacin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity