2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112658
    p-Iodoclonidine hydrochloride 108294-57-1 98%
    p-Iodoclonidine hydrochloride is a partial agonist of α2-adrenergic receptor. p-Iodoclonidine hydrochloride also has minimal agonist activity in inhibiting adenylate cyclase in platelet membranes, and potentiates ADP induced platelet aggregation with an EC50 of 1.5 μM.
    p-Iodoclonidine hydrochloride
  • HY-113157
    Estrone 3-glucuronide 2479-90-5 98%
    Estrone 3-glucuronide, the urinary metabolite of Estradiol (HY-B0141), is an urinary marker for prediction of the fertile window.
    Estrone 3-glucuronide
  • HY-113350
    Thromboxane A2 57576-52-0 98%
    Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses.
    Thromboxane A2
  • HY-113537
    Demegestone 10116-22-0 98%
    Demegestone is an agonist of theprogesterone receptor.
    Demegestone
  • HY-113778
    15-keto-17-phenyl trinor Prostaglandin F2α 949564-89-0 98%
    15-keto-17-phenyl trinor Prostaglandin F2α (15-keto-17-phenyl trinor PGF2α) is an F-series prostaglandin (PG) analog. The potential metabolite of 15-keto-17-phenyl trinor Prostaglandin F2α in animals is 15-keto PG. 15-keto PG can slightly reduce the intraocular pressure (1 mm Hg) in normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto-17-phenyl trinor Prostaglandin F2α is a miotic agent in cats, reducing the pupil diameter by 8 mm at a dose of 5 μg/eye.
    15-keto-17-phenyl trinor Prostaglandin F2α
  • HY-113887
    Prostaglandin F1β 10164-73-5 98%
    Prostaglandin F1β (PGF1β) is the C-9 epimer of 1α. Prostaglandin F1β increased the respiratory rate of rabbits.
    Prostaglandin F1β
  • HY-113909
    Dinoprost (methoxyamine) 101913-98-8 98%
    Dinoprost methoxyamine is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost methoxyamine is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost methoxyamine plays a key role in the onset and progression of labour.
    Dinoprost (methoxyamine)
  • HY-114656
    Dihydro-PGF1α 20592-20-5 98%
    Dihydro-PGF1α is a potential metabolite of PGF1α.
    Dihydro-PGF1α
  • HY-114707
    Threonyl-seryl-lysine 71730-64-8 98%
    Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5.
    Threonyl-seryl-lysine
  • HY-114793
    AL-12180 748816-43-5 98%
    AL-12180 is a potent and selective FP-receptor agonist with a Ki of 143 nM. AL-12180 stimulates the mobilization of intracellular Ca2+ in h-TM and h-CM cells with EC50s of 111 and 11 nM, respectively.
    AL-12180
  • HY-114850
    5-trans Prostaglandin F2β 36150-02-4 98%
    5-trans Prostaglandin F2β (5-trans-PGF2β) is the 9β-hydroxy isomer of 5-trans PGF2α.
    5-trans Prostaglandin F2β
  • HY-114867
    (15R)-Bimatoprost 1163135-92-9 98%
    (15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to treat glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15.
    (15R)-Bimatoprost
  • HY-114892
    15-A2t-Isoprostane 474391-66-7 98%
    15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid.
    15-A2t-Isoprostane
  • HY-115615
    VUF11207 TFA 1492153-74-8 98%
    VUF11207 (Compound 29) TFA is a CXCR7 agonist (pKi of 8.1) that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7.
    VUF11207 TFA
  • HY-115769
    1,2-Didecanoylglycerol 17863-69-3 98%
    1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA10) and activates protein kinase C (PKC).
    1,2-Didecanoylglycerol
  • HY-116066
    YM471 free base 183173-00-4 98%
    YM471 free base is a non-peptide antagonist of vasopressin V1A and V2 receptors with potent and persistent antagonistic activity. YM471 exhibits high affinity for rat V1A and V2 receptors with K values of 0.16 and 0.77 nM, respectively.
    YM471 free base
  • HY-116169
    KUC-7322 255734-04-4 98%
    KUC-7322, a selective β3 -adrenoceptor agonist, is the active form of ritobegron. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.
    KUC-7322
  • HY-116222
    A 53693 115103-48-5 98%
    A 53693 is a rigid catecholamine with selective adrenergic agonist activity. A 53693 has affinity for certain rat alpha-2 receptor subtypes. A 53693 shows high selectivity for alpha-2 receptors and, in contrast, has low affinity for alpha-1 receptors. A 53693 is used as a probe in biological studies to explore the molecular interactions of alpha agonist compounds.
    A 53693
  • HY-116250
    Prostaglandin D2-1-glyceryl ester 309260-52-4 98%
    Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester).
    Prostaglandin D2-1-glyceryl ester
  • HY-116591
    8-Iso-15-keto prostaglandin F2β 1621482-36-7 98%
    8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs.
    8-Iso-15-keto prostaglandin F2β
Cat. No. Product Name / Synonyms Application Reactivity