2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P3069
    γ-Neuropeptide (rabbit) 114882-65-4 99.99%
    γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.
    γ-Neuropeptide (rabbit)
  • HY-P3582
    sGnRH-A 96497-82-4 99.87%
    sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A stimulates growth hormone secretion. sGnRH-A also can be used as an inducer of ovulation by artificial insemination.
    sGnRH-A
  • HY-P4675
    LHRH free acid 35263-73-1 99.92%
    LHRH (free acid), the luteinizing hormone-releasing hormone, is a neuropeptide hypothalamic. LHRH regulates reproduction. LHRH can be used for the research of cancer.
    LHRH free acid
  • HY-P4697
    pTH (44-68) (human) 64421-69-8 98%
    pTH (44-68) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (44-68) (human)
  • HY-P4715
    (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) 213779-11-4 99.08%
    (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) is a peptide and can be used as a parathyroid hormone (PTH) receptor ligand.
    (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)
  • HY-P4750
    Acetyl-(D-Arg2)-GRF (1-29) amide (human) 93942-91-7 99.67%
    Acetyl-(D-Arg2)-GRF (1-29) amide (human) is an antagonist of growth hormone releasing factor (GRF). Acetyl-(D-Arg2)-GRF (1-29) amide (human) inhibits the release of growth hormone (GH) and can be used for endocrine research.
    Acetyl-(D-Arg2)-GRF (1-29) amide (human)
  • HY-P5213
    Vasopressin Dimer (parallel) (TFA) 99.55%
    Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR.
    Vasopressin Dimer (parallel) (TFA)
  • HY-P5269
    Palmitoyl tetrapeptide-10 887140-79-6 99.46%
    Palmitoyl tetrapeptide-10 is a bioactive peptide. Palmitoyl tetrapeptide-10 works synergistically with other active ingredients to increase the expression of corneodesmosin (a marker of keratinocyte adhesion) and filaggrin (a marker of keratinocyte terminal differentiation), thereby reducing skin permeability and improving skin barrier function. Palmitoyl tetrapeptide-10 can be used in the research of sensitive skin syndrome and skin pigmentation.
    Palmitoyl tetrapeptide-10
  • HY-P7061
    ALX 40-4C 143413-49-4
    ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.
    ALX 40-4C
  • HY-10011A
    (S)-SCH 563705 99.94%
    (S)-SCH 563705 is a S-enantiomer of SCH 563705. SCH 563705 (compound 16) is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively.
    (S)-SCH 563705
  • HY-100300
    AGN 192836 171102-29-7 99.49%
    AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
    AGN 192836
  • HY-100304
    KW-8232 free base 170365-25-0
    KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
    KW-8232 free base
  • HY-100331
    MCH-1 antagonist 1 1039825-68-7 98%
    MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.
    MCH-1 antagonist 1
  • HY-100850
    Piperoxan hydrochloride 135-87-5 99.66%
    Piperoxan (Benodaine) hydrochloride is an α2 adrenoceptor antagonist. Piperoxan hydrochloride is the first-generation antihistamine.
    Piperoxan hydrochloride
  • HY-101458
    IT1t 864677-55-4 98%
    IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.
    IT1t
  • HY-101717
    Indanidine 85392-79-6 99.89%
    Indanidine is a selective alpha-adrenergic agonist. Indanidine shows a partial agonist in rat aorta.
    Indanidine
  • HY-101755
    Tedatioxetine hydrobromide 960151-65-9 99.83%
    Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. ,
    Tedatioxetine hydrobromide
  • HY-101815
    Lidanserin 73725-85-6 ≥98.0%
    Lidanserin (ZK-33839) acts as a 5-HT2A and α1-adrenergic receptor antagonist.
    Lidanserin
  • HY-103204
    RS100329 hydrochloride 1215654-26-4 99.57%
    RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia.
    RS100329 hydrochloride
  • HY-105128
    Epostane 80471-63-2 99.0%
    Epostane (WIN 32729) is an orally active inhibitor for 3β-hydroxysteroid dehydrogenase, with IC50 of 1.45 nM. Epostane blocks ovulation and pregnancy in rats.
    Epostane
Cat. No. Product Name / Synonyms Application Reactivity