2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P991290
    IRAB-B 98.30%
    IRAB-B is a human monoclonal antibody targeting INSR. IRAB-B is an insulin receptor (IR) antagonist and can be used in the study of insulin resistance and diabetes.
    IRAB-B
  • HY-W014332
    1,3-Diphenylguanidine 102-06-7 99.76%
    1,3-Diphenylguanidine is a widely used accelerator in rubber vulcanization. 1,3-Diphenylguanidine increases ROS activity and decreases SOD and CAT activity. 1,3-Diphenylguanidine accelerates the vulcanization process. 1,3-Diphenylguanidine impairs the reproduction and growth of Moina macrocopa[1] [2] [3] .
    1,3-Diphenylguanidine
  • HY-W759404
    Clascoterone-d5
    Clascoterone-d5 (Cortexolone 17 alpha-propionate-d5) is the deuterated analog of Clascoterone. Clascoterone is a topical and peripheral androgen antagonist.
    Clascoterone-d5
  • HY-113405S1
    21-Deoxycortisol-d8 2479914-04-8 98.79%
    21-Deoxycortisol-d8 is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia.
    21-Deoxycortisol-d8
  • HY-W014332R
    1,3-Diphenylguanidine (Standard) 102-06-7 99.63%
    1,3-Diphenylguanidine (Standard) is the analytical standard of 1,3-Diphenylguanidine (HY-W014332). This product is intended for research and analytical applications. 1,3-Diphenylguanidine is a widely used accelerator in rubber vulcanization. 1,3-Diphenylguanidine increases ROS activity and decreases SOD and CAT activity. 1,3-Diphenylguanidine accelerates the vulcanization process. 1,3-Diphenylguanidine impairs the reproduction and growth of Moina macrocopa[1] [2] [3] .
    1,3-Diphenylguanidine (Standard)
  • HY-14880B
    Bavisant dihydrochloride hydrate 1103522-80-0 99.26%
    Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research.
    Bavisant dihydrochloride hydrate
  • HY-18204S
    Valsartan-d9 1089736-73-1 ≥99.0%
    Valsartan-d9 is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
    Valsartan-d9
  • HY-13715AR
    Norepinephrine hydrochloride (Standard) 329-56-6 99.58%
    Norepinephrine (hydrochloride) (Standard) is the analytical standard of Norepinephrine (hydrochloride). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].
    Norepinephrine hydrochloride (Standard)
  • HY-B0157AS
    Ketotifen-d3 fumarate 1795138-23-6 99.23%
    Ketotifen-d3 (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.
    Ketotifen-d3 fumarate
  • HY-10259
    PD 123319 130663-39-7 98%
    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
    PD 123319
  • HY-12981
    RG7713 920022-47-5 99.92%
    RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
    RG7713
  • HY-14407
    Fosaprepitant 172673-20-0 98%
    Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).
    Fosaprepitant
  • HY-B0371
    Terazosin 63590-64-7 98%
    Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.
    Terazosin
  • HY-101217
    BI 689648 1633009-87-6 99.20%
    BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively.
    BI 689648
  • HY-112154
    CXCR7 modulator 2 2227426-37-9 98.71%
    CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.
    CXCR7 modulator 2
  • HY-159844
    Gridegalutamide 2446929-86-6 98%
    Gridegalutamide has antiandrogen and antitumor activities.
    Gridegalutamide
  • HY-W744625
    Olodaterol-d3 hydrochloride 99.9%
    Olodaterol-d3 hydrochloride (BI1744-d3 hydrochloride) is the deuterium labeled Olodaterol hydrochloride (HY-14301A). Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.
    Olodaterol-d3 hydrochloride
  • HY-12131
    DMP 696 202578-52-7 99.03%
    DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.
    DMP 696
  • HY-19923
    Aganepag isopropyl 910562-20-8 98.23%
    Aganepag isopropyl (AGN-210961) is an EP2 agonist.
    Aganepag isopropyl
  • HY-111501
    H4R antagonist 1 1429375-54-1 99.82%
    H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC50 of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.
    H4R antagonist 1
Cat. No. Product Name / Synonyms Application Reactivity