2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-50760
    L-692585 145455-35-2 99.32%
    L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release.
    L-692585
  • HY-76937
    Impurity of Doxercalciferol 127516-23-8
    Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.
    Impurity of Doxercalciferol
  • HY-77111
    cis-INCB3344 1285539-85-6
    cis-INCB3344 is the isomer of INCB3344 (HY-50674), and can be used as an experimental control. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
    cis-INCB3344
  • HY-A0069
    Doxylamine succinate 562-10-7 99.76%
    Doxylamine (succinate), a first generation antihistamine, is a histamine (H1) receptor antagonist. Doxylamine is also a local analgesic agent and effective hypnotic agent.
    Doxylamine succinate
  • HY-B0487
    Ethisterone 434-03-7
    Ethisterone (Pregneninolone), a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone is reported for androgenic activity, used for the research of the gynecological disorders.
    Ethisterone
  • HY-B0601
    Tafluprost acid 209860-88-8 99.80%
    Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma.
    Tafluprost acid
  • HY-B0794
    AZ7550 1421373-99-0 98%
    AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
    AZ7550
  • HY-B1303
    Mebhydrolin napadisylate 6153-33-9 99.93%
    Mebhydrolin napadisylate is a specific histamine H1 receptor antagonist.
    Mebhydrolin napadisylate
  • HY-B1341
    Norethynodrel 68-23-5
    Norethynodrel (Enidre) is a 19-nortestosterone derivative to be used as a progestagen. Norethynodrel can be used for researching inhibition of ovulation. Norethynodrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethynodrel
  • HY-B1353
    Paroxypropione 70-70-2 99.97%
    Paroxypropione is a manufactured, nonsteroidal estrogen which has been used medically as an antigonadotropin.
    Paroxypropione
  • HY-B1607
    Chlorphenoxamine 77-38-3
    Chlorphenoxamine is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent.
    Chlorphenoxamine
  • HY-N2448
    Lindleyin 59282-56-3 99.95%
    Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity.
    Lindleyin
  • HY-N4088
    Pseudolaric acid A-O-β-D-glucopyranoside 98891-44-2 ≥99.0%
    Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities.
    Pseudolaric acid A-O-β-D-glucopyranoside
  • HY-N4188
    N-Benzyloctadecanamide 5327-45-7 ≥98.0%
    N-Benzyloctadecanamide (N-Benzylstearamide) is a macamide, a distinct class of secondary metabolites in Lepidium meyenii Walp. (Maca).
    N-Benzyloctadecanamide
  • HY-N4200
    S-Dihydrodaidzein 879559-75-8 98%
    S-Dihydrodaidzein is the (S)-enantiomer of dihydrodaidzein which is one of the most prominent dietary phytoestrogens.
    S-Dihydrodaidzein
  • HY-N8460
    Cortisol sulfate 1253-43-6 98%
    Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate is a specific ligand for intracellular transcortin.
    Cortisol sulfate
  • HY-N9917
    Galloylalbiflorin 929042-36-4
    Galloylalbiflorin (6′-O-Galloylalbiflorin) is an androgen receptor (AR) antagonist (IC50=53.3 μM) and can be found in the roots of Paeonia lactiflora. Galloylalbiflorin shows anti-androgens activity.
    Galloylalbiflorin
  • HY-P0009
    Cetrorelix 120287-85-6 98%
    Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice.
    Cetrorelix
  • HY-P0089
    Human growth hormone-releasing factor 83930-13-6 98%
    Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.
    Human growth hormone-releasing factor
  • HY-P0242
    Neurokinin B 86933-75-7 98%
    Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.
    Neurokinin B
Cat. No. Product Name / Synonyms Application Reactivity